Published in:
Open Access
01-12-2014 | Meeting abstract
EHMTI-0048. Epigenetic changes in a rat model of migraine with aura
Authors:
M Vila-Pueyo, N Fernández-Castillo, B Cormand, P Pozo-Rosich, A Macaya
Published in:
The Journal of Headache and Pain
|
Special Issue 1/2014
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Excerpt
Migraine with aura (MA) is a subtype of migraine characterized by reversible neurological disturbances preceding headache. Epigenetic mechanisms are postulated to mediate migraine susceptibility. MA neurophysiological correlate is cortical spreading depression (CSD), a wave of neuronal depolarization and depression that is suppressed by chronic administration of the migraine preventive drugs valproate and topiramate. …