Published in:
Open Access
01-12-2014 | Meeting abstract
EHMTI-0117. CGRP infusion in awake rats does not increase expression of immediate early genes, c-fos and zif268, in the trigeminal nucleus caudalis
Authors:
DK Bhatt, R Ramachandran, SLT Christensen, S Gupta, I Jansen-Olesen, J Olesen
Published in:
The Journal of Headache and Pain
|
Special Issue 1/2014
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Excerpt
Calcitonin gene-related peptide (CGRP) and glyceryl trinitrate (GTN) infusion in migraineurs provokes headache resembling spontaneous migraine. GTN infusion model was transformed to rats causing expression of protein markers as a surrogate for headache. We hypothesized that CGRP infusion in awake rats would increase molecular markers of neuronal activation in migraine relevant tissues. …