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The Journal of Headache and Pain

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Open Access 01-12-2013 | Case report

Spontaneous intracerebral hemorrhage in CADASIL

Authors: Lifei Lian, Dujuan Li, Zheng Xue, Qiming Liang, Feng Xu, Huicong Kang, Xiaoyan Liu, Suiqiang Zhu

Published in: The Journal of Headache and Pain | Issue 1/2013

Abstract

Background

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary small vascular disease and its mainly clinical manifestations are ischemic events. Spontaneous intracerebral hemorrhage (ICH) involvement in patients with CADASIL is extremely uncommon.

Case report

A 46-year-old normotensive Chinese man developed a large hematoma in the left basal ganglia after he was diagnosed with CADASIL 2 months ago, the patient did not take any antithrombotics. Susceptibility weighted imaging at pre-ICH showed multiple cerebral microbleeds (CMBs) in the bilateral basal ganglia. He experienced migraine at about 10 months post-ICH. To our knowledge, this is the first report of ICH in CADASIL patients with Arg90Cys mutation in exon 3.

Discussion and conclusions

ICH should be considered when evaluating new attacks in CADASIL patients. Thus, MRI screening for CMBs might be helpful in predicting the risk of ICH and guiding antithrombotic therapy. In addition, strict control of hypertension and cautious use of antithrombotics may be important in this context.

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Title: Spontaneous intracerebral hemorrhage in CADASIL
Authors: Lifei Lian
Dujuan Li
Zheng Xue
Qiming Liang
Feng Xu
Huicong Kang
Xiaoyan Liu
Suiqiang Zhu
Publication date: 01-12-2013
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/1129-2377-14-98

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Springer Medicine

Spontaneous intracerebral hemorrhage in CADASIL

Abstract

Background

Case report

Discussion and conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case report

Discussion and conclusions

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