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Maxillofacial Plastic and Reconstructive Surgery

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Open Access 01-12-2018 | Research

Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats

Authors: Hyun Seok, Seong-Gon Kim, Min-Keun Kim, Insan Jang, Janghoon Ahn

Published in: Maxillofacial Plastic and Reconstructive Surgery | Issue 1/2018

Abstract

Background

The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo.

Methods

Eleven Sprague-Dawley rats were used, and BTX-A (n = 6) or saline (n = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis.

Results

The anthropometric analysis found that the ramus heights and bigonial widths of the BTX-A-injected group were significantly smaller than those of the saline-injected group (P < 0.05), and the mandibular plane angle of the BTX-A-injected group was significantly greater than in the saline-injected group (P < 0.001). In the BTX-A-injected group, the ramus heights II and III and the mandibular plane angles I and II showed significant differences between the injected and non-injected sides (P < 0.05). The BTX-A-injected side of the mandible in the masseter group showed significantly lower mandibular bone growth compared with the non-injected side.

Conclusion

BTX-A injection into the masseter muscle influences mandibular bone growth.

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Title: Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats
Authors: Hyun Seok
Seong-Gon Kim
Min-Keun Kim
Insan Jang
Janghoon Ahn
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: Maxillofacial Plastic and Reconstructive Surgery / Issue 1/2018
Electronic ISSN: 2288-8586
DOI: https://doi.org/10.1186/s40902-018-0146-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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