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Open Access 01-12-2016 | Research

The role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment

Authors: Hyo-Sang Hwang, Kwang-Pil Ko, Myeong Gun Kim, Sihun Kim, Jeonggeun Moon, Wook Jin Chung, Mi Seung Shin, Seung Hwan Han

Published in: Clinical Hypertension | Issue 1/2015

Abstract

Background

Subjects with abnormal metabolic conditions had increased risk for cardiovascular disease. We investigated the role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment.

Methods

A total 601 subjects (age 48.7 ± 11.8 years, male 46.2 %, hypertension 19.1 %) were enrolled. Major cardiovascular risk factors, metabolic conditions and parameters (pre-diabetes, diabetes mellitus, metabolic syndrome, fasting blood sugar (FBS), glycated hemoglobin), lipid profiles, hsCRP, and brachial ankle pulse wave velocity (baPWV) were measured.

Results

Subjects with metabolic syndrome (n = 200) had higher baPWV than in subjects without metabolic syndrome (n = 401) even after adjustments for age, sex and presence of hypertension (1435.9 ± 212.2 vs. 1336.5 ± 225.0 cm/sec, p < 0.001). The differences of baPWV among normal FBS, prediabetes and diabetes mellitus groups are significant (P for trend = 0.036) by multivariate analysis (adjustments for age, sex, office systolic blood pressure). Subjects with diabetes mellitus (n = 30) had higher baPWV than in subjects with normal FBS (n = 384, 1525 ± 267.1 vs. 1341.5 ± 224.1 cm/sec, P = 0.016 adjustments for age, sex, office systolic blood pressure). BaPWV in subjects with prediabetes (n = 187) was slightly higher, but not statistically significant than in subjects with normal FBS (P = 0.377). Of interest, FBS was one of the independent predictors for increased baPWV (β = 0.809, 95 % CI 0.222-1.397, p = 0.007) by multivariate analysis.

Conclusions

Subjects with abnormal metabolic conditions have increased arterial stiffness independent of age and BP which may contribute to the development of cardiovascular disease.

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Title: The role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment
Authors: Hyo-Sang Hwang
Kwang-Pil Ko
Myeong Gun Kim
Sihun Kim
Jeonggeun Moon
Wook Jin Chung
Mi Seung Shin
Seung Hwan Han
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Clinical Hypertension / Issue 1/2015
Electronic ISSN: 2056-5909
DOI: https://doi.org/10.1186/s40885-016-0049-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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