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International Journal of Implant Dentistry

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Open Access 01-12-2022 | Tooth Extraction | Research

A 3-year prospective randomized clinical trial of alveolar bone crest response and clinical parameters through 1, 2, and 3 years of clinical function of implants placed 4 months after alveolar ridge preservation using two different allogeneic bone-grafting materials

Authors: Önder Solakoğlu, Duygu Ofluoğlu, Heidi Schwarzenbach, Guido Heydecke, Daniel Reißmann, Sertan Ergun, Werner Götz

Published in: International Journal of Implant Dentistry | Issue 1/2022

Abstract

Purpose

The aim of this study was to longitudinally evaluate changes in alveolar bone crest (ABC) levels and differences in resorption rates (RR) between the tested grafting materials following alveolar ridge preservation (ARP) after tooth extraction after 1, 2, and 3 years (T1–T8) of clinical function.

Methods

Patients were randomly assigned to two different bone allografts (group 1 maxgraft^®, group 2 Puros^®) for ARP. Non-restorable teeth were minimal traumatically extracted. Sockets were augmented with the tested materials and covered with a pericardium membrane. After 4 months of healing, 36 implants were placed and sites were clinically and radiographically monitored in the mesial (ABC-M), the distal (ABC-D, T1–T8), the bucco-lingual (ABC-BL), buccal (ABC-B) and oral (ABC-O) aspect (T1–T4).

Results

Changes in (ABC-M), (ABC-D), (ABC-BL), (ABC-B), and (ABC-O) levels showed statistically highly significant differences between T1 and T2 for both bone allografts (p < 0.001). Changes at the ABC-M and ABC-BL levels between T2 and T3 of group 1 showed a statistically significant difference (p < 0.001). Both groups achieved and maintained increased ABC levels without statistically significant differences throughout the monitoring periods of 1–3 years (T6–T8) of clinical function. No failures or adverse events were observed.

Conclusions

To the best of our knowledge, this study is within its limitations the first study to directly compare ABC-changes and differences in RR of two different allogeneic grafting materials for a period of 3 years after ARP. It was demonstrated to be, despite significant differences in RR, a successful method of preserving increased ABC levels through 1, 2, and 3 years of clinical function.

Trial registration DRKS00013010, registered 07/30/2018, http://apps.who.int/trialsearch

Ormianer Z, Palti A, Demiralp B, Heller G, Lewinstein I, Khayat PG. Implant-supported first molar restorations: correlation of finite element analysis with clinical outcomes. Int J Oral Maxillofac Implants. 2012;27(1):e1-12.PubMed

Wolff J. Das Gesetz der Transformation der Knochen, 1892 (Hirschwald, Berlin). Google Scholar.

Fernandes PG, Novaes ABJ, de Queiroz AC, et al. Ridge preservation with acellular dermal matrix and anorganic bone matrix cell-binding peptide P-15 after tooth extraction in humans. J Periodontol. 2011;82(1):72–9. https://doi.org/10.1902/jop.2010.100241.CrossRefPubMed

Sculean A, Stavropoulos A, Bosshardt D. Self-regenerative capacity of intra-oral bone defects. J Clin Periodontol. 2019;46:70–81.CrossRef

Lekovic V, Camargo PM, Klokkevold PR, et al. Preservation of alveolar bone in extraction sockets using bioabsorbable membranes. J Periodontol. 1998;69(9):1044–9. https://doi.org/10.1902/jop.1998.69.9.1044.CrossRefPubMed

Lekovic V, Kenney EB, Weinlaender M, et al. A bone regenerative approach to alveolar ridge maintenance following tooth extraction. Report of 10 cases. J Periodontol. 1997;68(6):563–70. https://doi.org/10.1902/jop.1997.68.6.563.CrossRefPubMed

van der Weijden F, Dell’Acqua F, Slot DE. Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review. J Clin Periodontol. 2009;36(12):1048–58. https://doi.org/10.1111/j.1600-051X.2009.01482.x.CrossRefPubMed

Pagni G, Pellegrini G, Giannobile WV, Rasperini G. Postextraction alveolar ridge preservation: biological basis and treatments. Int J Dent. 2012;2012:151030. https://doi.org/10.1155/2012/151030.CrossRefPubMedPubMedCentral

Trombelli L, Minenna P, Franceschetti G, Minenna L, Itro A, Farina R. Minimally invasive technique for transcrestal sinus floor elevation: a case report. Quintessence Int. 2010;41(5):363–9.PubMed

10.

Tan WL, Wong TLT, Wong MCM, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implant Res. 2012;23(Suppl 5):1–21. https://doi.org/10.1111/j.1600-0501.2011.02375.x.CrossRef

11.

Vignoletti F, Matesanz P, Rodrigo D, Figuero E, Martin C, Sanz M. Surgical protocols for ridge preservation after tooth extraction. A systematic review. Clin Oral Implants Res. 2012;23(Suppl5):22–38. https://doi.org/10.1111/j.1600-0501.2011.02331.x.CrossRefPubMed

12.

Morjaria KR, Wilson R, Palmer RM. Bone healing after tooth extraction with or without an intervention: a systematic review of randomized controlled trials. Clin Implant Dent Relat Res. 2014;16(1):1–20. https://doi.org/10.1111/j.1708-8208.2012.00450.x.CrossRefPubMed

13.

Ahmad R, Chen J, Abu-Hassan MI, Li Q, Swain MV. Investigation of mucosa-induced residual ridge resorption under implant-retained overdentures and complete dentures in the mandible. Int J Oral Maxillofac Implants. 2015;30(3):657–66.CrossRef

14.

Chen J, Ahmad R, Suenaga H, Li W, Swain M, Li Q. A comparative study on complete and implant-retained denture treatments: a biomechanics perspective. J Biomech. 2015;48(3):512–9. https://doi.org/10.1016/j.jbiomech.2014.11.043.CrossRefPubMed

15.

Lang NP, Pun L, Lau KY, Li KY, Wong MCM. A systematic review on survival and success rates of implants placed immediately into fresh extraction sockets after at least 1 year. Clin Oral Implant Res. 2012;23(Suppl 5):39–66. https://doi.org/10.1111/j.1600-0501.2011.02372.x.CrossRef

16.

Lee CT, Chiu TS, Chuang SK, Tarnow D, Stoupel J. Alterations of the bone dimension following immediate implant placement into extraction socket: systematic review and meta-analysis. J Clin Periodontol. 2014;41(9):914–26. https://doi.org/10.1111/jcpe.12276.CrossRefPubMed

17.

Block MS, Scoggin ZD, Yu Q. Assessment of bone width for implants in the posterior mandible. J Oral Maxillofac Surg. 2015;73(9):1715–22. https://doi.org/10.1016/j.joms.2015.03.036.CrossRefPubMed

18.

Horvath A, Mardas N, Mezzomo LA, Needleman IG, Donos N. Alveolar ridge preservation. A systematic review. Clin Oral Invest. 2013;17(2):341–63. https://doi.org/10.1007/s00784-012-0758-5.CrossRef

19.

Khojasteh A, Kheiri L, Motamedian SR, Nadjmi N. Regenerative medicine in the treatment of alveolar cleft defect: a systematic review of the literature. J Cranio-maxillo-facial Surg. 2015;43(8):1608–13. https://doi.org/10.1016/j.jcms.2015.06.041.CrossRef

20.

Danesh-Sani SA, Engebretson SP, Janal MN. Histomorphometric results of different grafting materials and effect of healing time on bone maturation after sinus floor augmentation: a systematic review and meta-analysis. J Periodontal Res. 2017;52(3):301–12. https://doi.org/10.1111/jre.12402.CrossRefPubMed

21.

Garcia-Gareta E, Coathup MJ, Blunn GW. Osteoinduction of bone grafting materials for bone repair and regeneration. Bone. 2015;81:112–21. https://doi.org/10.1016/j.bone.2015.07.007.CrossRefPubMed

22.

Dumitrescu AL. Bone grafts and bone graft substitutes in periodontal therapy. Chem Surg Periodontal Therapy. 2011:73–144.

23.

Hoexter DL. Bone regeneration graft materials. J Oral Implantol. 2002;28(6):290–4. https://doi.org/10.1563/1548-1336(2002)028%3c0290:BRGM%3e2.3.CO;2.CrossRefPubMed

24.

Gapski R, Neiva R, Oh TJ, Wang HL. Histologic analyses of human mineralized bone grafting material in sinus elevation procedures: a case series. Int J Periodontics Restorative Dent. 2006;26(1):59–69.PubMed

25.

Froum SJ, Tarnow DP, Wallace SS, et al. The use of a mineralized allograft for sinus augmentation: an interim histological case report from a prospective clinical study. Compendium Continuing Educ Dent. 2005;26(4):259–60.

26.

Solakoglu Ö, Götz W, Heydecke G. Histological and immunohistochemical comparison of two different allogeneic bone grafting materials for alveolar ridge reconstruction: a prospective randomized trial in humans. Clin Implant Dent Relat Res. 2019. https://doi.org/10.1111/cid.12824.CrossRefPubMedPubMedCentral

27.

de Risi V, Clementini M, Vittorini G, Mannocci A, de Sanctis M. Alveolar ridge preservation techniques: a systematic review and meta-analysis of histological and histomorphometrical data. Clin Oral Implants Res. 2015. https://doi.org/10.1111/clr.12288.CrossRefPubMed

28.

Canellas JVdS, Ritto FG, Figueredo CMdS, et al. Histomorphometric evaluation of different grafting materials used for alveolar ridge preservation: a systematic review and network meta-analysis. Int J Oral Maxillofac Surg. 2020. https://doi.org/10.1016/j.ijom.2019.10.007.CrossRefPubMed

29.

Serrano Méndez CA, Lang NP, Caneva M, Ramírez Lemus G, Mora Solano G, Botticelli D. Comparison of allografts and xenografts used for alveolar ridge preservation. A clinical and histomorphometric RCT in humans. Clin Implant Dent Relat Res. 2017. https://doi.org/10.1111/cid.12490.CrossRefPubMed

30.

Perelman-Karmon M, Kozlovsky A, Liloy R, Artzi Z. Socket site preservation using bovine bone mineral with and without a bioresorbable collagen membrane. Int J Periodontics Restorative Dent. 2012;32(4):459–65.PubMed

31.

Pang C, Ding Y, Zhou H, et al. Alveolar ridge preservation with deproteinized bovine bone graft and collagen membrane and delayed implants. J Craniofac Surg. 2014;25(5):1698–702. https://doi.org/10.1097/SCS.0000000000000887.CrossRefPubMed

32.

Araujo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005;32(2):212–8. https://doi.org/10.1111/j.1600-051X.2005.00642.x.CrossRefPubMed

33.

von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. Int J Surg (London, England). 2014;12(12):1495–9. https://doi.org/10.1016/j.ijsu.2014.07.013.CrossRef

34.

Anitua E, Alkhraisat MH, Orive G. Long-term outcome of transosteotomy bone augmentation of the inferior border of the severely resorbed mandible. Implant Dent. 2015;24(2):236–9. https://doi.org/10.1097/ID.0000000000000221.CrossRefPubMed

35.

Anitua E, Sanchez M, Merayo-Lloves J, de la Fuente M, Muruzabal F, Orive G. Plasma rich in growth factors (PRGF-Endoret) stimulates proliferation and migration of primary keratocytes and conjunctival fibroblasts and inhibits and reverts TGF-beta1-Induced myodifferentiation. Invest Ophthalmol Vis Sci. 2011;52(9):6066–73. https://doi.org/10.1167/iovs.11-7302.CrossRefPubMed

36.

Anitua E. The use of plasma-rich growth factors (PRGF) in oral surgery. Practical Procedures Aesthetic Dent PPAD. 2001;13(6):487–93.

37.

Hacker RJ, Cauthen JC, Gilbert TJ, Griffith SL. A prospective randomized multicenter clinical evaluation of an anterior cervical fusion cage. Spine. 2000;25(20):2646–54.CrossRef

38.

Ronda M, Stacchi C. A novel approach for the coronal advancement of the buccal flap. Int J Periodontics Restorative Dent. 2015;35(6):795–801.CrossRef

39.

el Chaar ES. Soft tissue closure of grafted extraction sockets in the posterior maxilla: the rotated pedicle palatal connective tissue flap technique. Implant Dent. 2010;19(5):370–7. https://doi.org/10.1097/ID.0b013e3181ed06cd.CrossRefPubMed

40.

Rodríguez Sánchez F, Arteagoitia I, Teughels W, Rodríguez Andrés C, Quirynen M. Antibiotic dosage prescribed in oral implant surgery: a meta-analysis of cross-sectional surveys. PLoS ONE. 2020. https://doi.org/10.1371/journal.pone.0236981.CrossRefPubMedPubMedCentral

41.

Rodríguez Sánchez F, Arteagoitia I, Rodríguez Andrés C, Bruers J. Antibiotic prophylaxis prescribing habits in oral implant surgery in the Netherlands: a cross-sectional survey. BMC Oral Health. 2019. https://doi.org/10.1186/s12903-019-0981-4.CrossRefPubMedPubMedCentral

42.

Kim A, Abdelhay N, Levin L, Walters JD, Gibson MP. Antibiotic prophylaxis for implant placement: a systematic review of effects on reduction of implant failure. Br Dent J. 2020. https://doi.org/10.1038/s41415-020-1649-9.CrossRefPubMedPubMedCentral

43.

Takeshita WM, Vessoni Iwaki LC, da Silva MC, Tonin RH. Evaluation of diagnostic accuracy of conventional and digital periapical radiography, panoramic radiography, and cone-beam computed tomography in the assessment of alveolar bone loss. Contemp Clin Dent. 2014;5(3):318–23. https://doi.org/10.4103/0976-237X.137930.CrossRefPubMedPubMedCentral

44.

Solakoglu Ö, Steinbach B, Götz W, Heydecke G, Pantel K, Schwarzenbach H. Characterization of circulating DNA in plasma of patients after allogeneic bone grafting. Clin Oral Invest. 2019. https://doi.org/10.1007/s00784-019-02867-3.CrossRef

45.

Ormianer Z, Palti A. Retrospective clinical evaluation of tapered screw-vent implants: results after up to eight years of clinical function. J Oral Implantol. 2008;34(3):150–60. https://doi.org/10.1563/1548-1336(2008)34[150:RCEOTS]2.0.CO;2.CrossRefPubMed

46.

Adell R, Lekholm U, Rockler B, Branemark PI. A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg. 1981;10(6):387–416.CrossRef

47.

Rasmusson L, Roos J, Bystedt H. A 10-year follow-up study of titanium dioxide-blasted implants. Clin Implant Dent Relat Res. 2005;7(1):36–42.CrossRef

48.

Schlee M, van der Schoor WP, van der Schoor ARM. Immediate loading of trabecular metal-enhanced titanium dental implants: interim results from an international proof-of-principle study. Clin Implant Dent Relat Res. 2015;17(Suppl 1):e308–20. https://doi.org/10.1111/cid.12127.CrossRefPubMed

49.

du Bois AH, Kardachi B, Bartold PM. Is there a role for the use of volumetric cone beam computed tomography in periodontics? Aust Dent J. 2012;57(Suppl 1):103–8. https://doi.org/10.1111/j.1834-7819.2011.01659.x.CrossRefPubMed

50.

Sardana V, Balappanavar AY, Deshpande S, Shigli A, Indushekar KR, Gogia G. Evaluation of marginal alveolar bone height for early detection of periodontal disease in pediatric population: clinical and radiographic study. J Contemp Dent Pract. 2014;15(1):37–45.CrossRef

51.

Richter S, Eliasson ST. Dental health in Viking age Icelanders. Bull Int Assoc Paleodontol. 2008;2(2):14–20.

52.

Wang RE, Lang NP. Ridge preservation after tooth extraction. Clin Oral Implants Res. 2012;23(6):147–56.CrossRef

53.

Chappuis V, Araújo MG, Buser D. Clinical relevance of dimensional bone and soft tissue alterations post-extraction in esthetic sites. Periodontol 2000. 2017;73(1):73–83.CrossRef

54.

Araújo MG, Silva CO, Misawa M, Sukekava F. Alveolar socket healing: what can we learn? Periodontol 2000. 2015;58(1):122–34.CrossRef

55.

Avila-Ortiz G, Elangovan S, Kramer KWO, Blanchette D, Dawson DV. Effect of alveolar ridge preservation after tooth extraction: a systematic review and meta-analysis. J Dental Res. 2014;93(10):950–8. https://doi.org/10.1177/0022034514541127.CrossRef

56.

Majzoub J, Ravida A, Starch-Jensen T, Tattan M, del Amo FS-L. The influence of different grafting materials on alveolar ridge preservation: a systematic review. J Oral Maxillofac Res. 2019;10(3).

57.

Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003;23(4):313–23.PubMed

58.

DI Farmer M. Ridge dimensional changes following single-tooth extraction in the aesthetic zone. Clin Oral Implants Res. 2014;25:272–7.CrossRef

59.

Tonetti MS, Jung RE, Avila-Ortiz G, Blanco J, Cosyn J, Fickl S, Figuero E, Goldsteii M, Graziani F, Madianos P, Molina A, Nart J, Salvi GE, Sanz-Martin I, Thoma D, Assche NV, Vignoletti F. Management of the extraction socket and timing of implant placement: consensus report and clinical recommendations of group 3 of the XV European Workshop in Periodontology. J Clin Periodontol. 2019;46(Suppl. 21):183–94.CrossRef

60.

Eskan MA, Greenwell H, Hill M, et al. Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trial. J Periodontol. 2014;85(5):661–8. https://doi.org/10.1902/jop.2013.130260.CrossRefPubMed

61.

Monje A, O’Valle F, Monje-Gil F, et al. Cellular, vascular, and histomorphometric outcomes of solvent-dehydrated vs freeze-dried allogeneic graft for maxillary sinus augmentation: a randomized case series. Int J Oral Maxillofac Implants. 2017;32(1):121–7. https://doi.org/10.11607/jomi.4801.CrossRefPubMed

62.

Wessels R, Vervaeke S, Seyssens L, Eghbali A, Cosyn J. A 5-year cohort study on early implant placement with guided bone regeneration or alveolar ridge preservation with connective tissue graft. Clin Implant Dent Relat Res. 2020;6:697–705.CrossRef

63.

Belser UC, Grütter L, Vailati F, Bornstein MM, Weber H-P, Buser D. Outcome evaluation of early placed maxillary anterior single-tooth implants using objective esthetic criteria: a cross-sectional, retrospective study in 45 patients with a 2- to 4-year follow-up using pink and white esthetic scores. J Periodontol. 2009;80(1):140–51.CrossRef

64.

Eghbali A, Seyssens L, De Bruyckere T, Younes F, Cleymaet R, Cosyn J. A 5-year prospective study on the clinical and aesthetic outcomes of alveolar ridge preservation and connective tissue graft at the buccal aspect of single implants. J Clin Periodontol. 2018;45(12):1475–84.CrossRef

65.

Ramachandra SS, Rana R, Reetika S, Jithendra KD. Options to avoid the second surgical site: a review of literature. Cell Tissue Banking. 2014;15(3):297–305. https://doi.org/10.1007/s10561-013-9395-8.CrossRefPubMed

66.

Patino MG, Neiders ME, Andreana S, Noble B, Cohen RE. Collagen: an overview. Implant Dent. 2002;11(3):280–5.CrossRef

67.

Miron RJ, Zhang Q, Sculean A, et al. Osteoinductive potential of 4 commonly employed bone grafts. Clin Oral Invest. 2016;20(8):2259–65. https://doi.org/10.1007/s00784-016-1724-4.CrossRef

Title: A 3-year prospective randomized clinical trial of alveolar bone crest response and clinical parameters through 1, 2, and 3 years of clinical function of implants placed 4 months after alveolar ridge preservation using two different allogeneic bone-grafting materials
Authors: Önder Solakoğlu
Duygu Ofluoğlu
Heidi Schwarzenbach
Guido Heydecke
Daniel Reißmann
Sertan Ergun
Werner Götz
Publication date: 01-12-2022
Publisher: Springer Berlin Heidelberg
Keywords: Tooth Extraction
Tooth Extraction
Published in: International Journal of Implant Dentistry / Issue 1/2022
Electronic ISSN: 2198-4034
DOI: https://doi.org/10.1186/s40729-022-00402-w

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A 3-year prospective randomized clinical trial of alveolar bone crest response and clinical parameters through 1, 2, and 3 years of clinical function of implants placed 4 months after alveolar ridge preservation using two different allogeneic bone-grafting materials

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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