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Clinical and Translational Medicine
Published in: Clinical and Translational Medicine 1/2015

Open Access 01-12-2015 | Review

EMT and tumor metastasis

Authors: Sarah Heerboth, Genevieve Housman, Meghan Leary, Mckenna Longacre, Shannon Byler, Karolina Lapinska, Amber Willbanks, Sibaji Sarkar

Published in: Clinical and Translational Medicine | Issue 1/2015

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Abstract

EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several types of tumors, and lastly, we discuss the role of epigenetic events that regulate EMT/MET processes. We hypothesize that reversible epigenetic events regulate both EMT and MET, and thus, also regulate the development of different types of metastatic cancers.
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Metadata
Title
EMT and tumor metastasis
Authors
Sarah Heerboth
Genevieve Housman
Meghan Leary
Mckenna Longacre
Shannon Byler
Karolina Lapinska
Amber Willbanks
Sibaji Sarkar
Publication date
01-12-2015
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2015
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-015-0048-3

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