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Open Access 01-12-2019 | NSCLC | Review

Achievements and futures of immune checkpoint inhibitors in non-small cell lung cancer

Authors: Zhenbin Qiu, Zihao Chen, Chao Zhang, Wenzhao Zhong

Published in: Experimental Hematology & Oncology | Issue 1/2019

Abstract

Non-small cell lung cancer (NSCLC) has been threatening human health for years. Cytotoxicity-based chemotherapy seems to reach plateau in NSCLC treatment. Immunotherapy with immune checkpoint inhibitors (ICIs) against programmed cell death 1 (PD-1/L1) axis are to provide long-term survival benefits for wild-type advanced NSCLC patients with acceptable adverse effects. Though beneficiary population is limited from monotherapy, combination strategies are expanding indicators. Retrospective evidences suggested ICIs are also potentially useful for brain metastasis. Furthermore, the combination of ICIs and surgery are to prolong progression free survival time for local advanced patients. Additionally, novel agents targeting in immune checkpoints other than PD-1/L1 demonstrated potential values in anticancer immunity. Herein, we summarize the novel therapies of checkpoint inhibitors in NSCLC treatment and some other potential immunotherapy to provide a conspectus for novel immunotherapy in NSCLC and perspective for the future in anti-cancer treatment.

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Title: Achievements and futures of immune checkpoint inhibitors in non-small cell lung cancer
Authors: Zhenbin Qiu
Zihao Chen
Chao Zhang
Wenzhao Zhong
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: NSCLC
NSCLC
Checkpoint Inhibitors
Cytostatic Therapy
Published in: Experimental Hematology & Oncology / Issue 1/2019
Electronic ISSN: 2162-3619
DOI: https://doi.org/10.1186/s40164-019-0143-z

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