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Experimental Hematology & Oncology

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Open Access 01-12-2015 | Case report

Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG

Authors: Katherine Linder, Deepthi Gandhiraj, Madhura Hanmantgad, Karen Seiter, Delong Liu

Published in: Experimental Hematology & Oncology | Issue 1/2015

Abstract

Background

The current standard of care for relapsed and refractory acute lymphoblastic leukemia (ALL) is combination chemotherapy.

Case presentation

We report a case of highly refractory ALL who was treated with blinatumomab. The ALL in this patient relapsed within a month after completion of hyperCVAD regimen and was refractory to high dose mitoxantrone/cytarabine and CLAG regimens.

Conclusion

This highly refractory pre-B Ph⁻ ALL was induced to complete remission after one course of single agent blinatumomab.

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Title: Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG
Authors: Katherine Linder
Deepthi Gandhiraj
Madhura Hanmantgad
Karen Seiter
Delong Liu
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Experimental Hematology & Oncology / Issue 1/2015
Electronic ISSN: 2162-3619
DOI: https://doi.org/10.1186/s40164-016-0051-4

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