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Open Access 01-12-2019 | Hyperglycemia | Protocol

The role of innate lymphoid cells and T helper cell activation in type 2 diabetic patients: a protocol for a systematic review and meta-analysis

Authors: Vuyolwethu Mxinwa, Tawanda M. Nyambuya, Phiwayinkosi V. Dludla, Bongani B. Nkambule

Published in: Systematic Reviews | Issue 1/2019

Abstract

Background

Persistent levels of low-grade inflammation and T lymphocyte activation are associated with insulin resistance and type 2 diabetes that eventually lead to the development of cardiovascular diseases. Interestingly, increasing studies report on an emerging role of innate lymphoid cells in the development of both type 2 diabetes and cardiovascular disease. This systematic review will provide a comprehensive synthesis of available studies reporting on the role of innate lymphoid cells and associated T helper cell function in type 2 diabetic patients. It will further provide insight into the association of innate lymphoid cell activation and cardiovascular risk in adults living with type 2 diabetes.

Methods

This systematic review protocol has been prepared in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 guidelines. The protocol has been registered with PROSPERO (CRD42018106159). This systematic review and meta-analysis will include published randomised clinical trials, observational studies, and case-control studies. We will also include grey literature. A search strategy will be developed with the help of subject librarian using Medical Subject Heading (MeSH) words for MEDLINE. This will then be adapted for the Embase database. Two independent reviewers VM and BBN will screen all studies using prespecified inclusion and exclusion criteria. The Downs and Black checklist will be used to assess the quality of individual studies. Predefined relevant data items will be extracted using sheets, and all study tables will be created using Review Manager V.5.3. The Grading of Recommendations Assessment, Development and Evaluation approach will be used to assess the strength of evidence.

Ethics and dissemination

The review will include publicly available data. The findings of this review will be disseminated through publications.

World Health Organisation/Fact sheets/Obesity and overweight [Internet]. [cited 2019 Mar 11]. Available from: https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight

Domingueti CP, Dusse LMS, Carvalho M das G, de Sousa LP, Gomes KB, Fernandes AP. Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. J Diabetes Complications [Internet]. 2016 [cited 2018 May 7];30(4):738–745. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1056872715005073

Patel PS, Buras EDBA. The role of the immune system in obesity and insulin resistance. J Obes. 2013;2013:1–9.

Wang M, Chen F, Wang J, Zeng Z, Yang Q, Shao S. Th17 and Treg lymphocytes in obesity and type 2 diabetic patients. Clin Immunol [Internet]. 2018;197(August):77–85. Available from: https://doi.org/10.1016/j.clim.2018.09.005 PubMedCrossRef

Kim SM, Lee SH, Kim YG, Kim SY, Seo JW, Choi YW, et al. Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy. Am J Physiol Ren Physiol [Internet]. 2015;308(9):F993-f1003. Available from: http://ajprenal.physiology.org/content/ajprenal/308/9/F993.full.pdf PubMedCrossRef

Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne). 2016;7:APR):1–16.CrossRef

Cautivo KM, Molofsky AB. Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells. Eur J Immunogenet. 2016;46:1315–25.PubMedPubMedCentralCrossRef

Lu P, Ji X, Wan J, Xu H. Activity of group 2 innate lymphoid cells is associated with chronic inflammation and dysregulated metabolic homoeostasis in type 2 diabetic nephropathy. 2017;99–107.

F Q, Wang H, Feng W, Ye X, Sun X, Jiang C, et al. ScienceDirect type 1 innate lymphoid cells are associated with type 2 diabetes. 2018;6–11.

10.

Galle-treger L, Sankaranarayanan I, Hurrell BP, Howard E, Lo R, Maazi H, et al. Type 2 diabetes. Nat Commun [Internet] 2019;1–14. Available from: https://doi.org/10.1038/s41467-019-08449-x

11.

Margetic S. Review inflammation and. Haemostasis. 2012;22(1):49–62.

12.

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev [Internet]. 2015;4(1):1–9. Available from: https://doi.org/10.1186/2046-4053-4-1%5Cnhttp://www.systematicreviewsjournal.com/content/4/1/1%5CnAll Papers/M/Moher et al. 2015 - Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement.pdf

13.

Fort MM, Cheung J, Yen D, Li J, Zurawski SM, Lo S, et al. IL-25 Induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity. 2001;15(6):985–95.PubMedCrossRef

14.

Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+lymphoid cells. Nature [Internet]. 2010;463(7280):540–544. Available from: https://doi.org/10.1038/nature08636 PubMedCrossRef

15.

Mjösberg JM, Trifari S, Crellin NK, Peters CP, Drunen CM Van, Piet B, et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. 2011;12(11).

16.

Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. 1998;377–384.

17.

Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ Br Med J. 2003;327(7414):557–60.CrossRef

18.

Schroll JB, Moustgaard R, Gøtzsche PC. Dealing with substantial heterogeneity in Cochrane reviews. Cross-sectional study. 2011;

19.

Group C, Synnot A, Glenton C, Cole S, Cumpston M. How to GRADE the quality of the evidence. CCCG Suppl Author Device [Internet]. 2016;1–24. Available from: http://cccrg.cochrane.org/author-resources

20.

Nyambuya TM, Dludla PV, Nkambule BB. T cell activation and cardiovascular risk in type 2 diabetes mellitus: a protocol for a systematic review and meta-analysis. Syst Rev. 2018;7(1):1–6.CrossRef

21.

Nkambule BB, Mkandla Z, Mutize T, Dludla PV. Platelet function and cardiovascular risk in adult HIV-infected patients on HAART: a protocol for a systematic review and meta-analysis. BMJ Open [Internet]. 2017;7(12):e019468. Available from: https://doi.org/10.1136/bmjopen-2017-019468 PubMedPubMedCentralCrossRef

Title: The role of innate lymphoid cells and T helper cell activation in type 2 diabetic patients: a protocol for a systematic review and meta-analysis
Authors: Vuyolwethu Mxinwa
Tawanda M. Nyambuya
Phiwayinkosi V. Dludla
Bongani B. Nkambule
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Hyperglycemia
Type 2 Diabetes
Published in: Systematic Reviews / Issue 1/2019
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-019-1144-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The role of innate lymphoid cells and T helper cell activation in type 2 diabetic patients: a protocol for a systematic review and meta-analysis

Abstract

Background

Methods

Ethics and dissemination

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Ethics and dissemination

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