Published in:
Open Access 01-12-2016 | Original research
Quantification of myocardial blood flow with 82Rb: Validation with 15O-water using time-of-flight and point-spread-function modeling
Published in: EJNMMI Research | Issue 1/2016
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Background
We quantified myocardial blood flow with 82Rb PET using parameters of the generalized Renkin-Crone model estimated from 82Rb and 15O-water images reconstructed with time-of-flight and point spread function modeling. Previous estimates of rubidium extraction have used older-generation scanners without time-of-flight or point spread function modeling. We validated image-derived input functions with continuously collected arterial samples.
Methods
Nine healthy subjects were scanned at rest and under pharmacological stress on the Siemens Biograph mCT with 82Rb and 15O-water PET, undergoing arterial blood sampling with each scan. Image-derived input functions were estimated from the left ventricle cavity and corrected with tracer-specific population-based scale factors determined from arterial data. Kinetic parametric images were generated from the dynamic PET images by fitting the one-tissue compartment model to each voxel’s time activity curve. Mean myocardial blood flow was determined from each subject’s 15O-water k
2 images. The parameters of the generalized Renkin-Crone model were estimated from these water-based flows and mean myocardial 82Rb K
1 estimates.
Results
Image-derived input functions showed improved agreement with arterial measurements after a scale correction. The Renkin-Crone model fit (a = 0.77, b = 0.39) was similar to those previously published, though b was lower.
Conclusions
We have presented parameter estimates for the generalized Renkin-Crone model of extraction for 82Rb PET using human 82Rb and 15O-water PET from high-resolution images using a state-of-the-art time-of-flight-capable scanner. These results provide a state-of-the-art methodology for myocardial blood flow measurement with 82Rb PET.