Skip to main content
Top
Published in: EJNMMI Research 1/2016

Open Access 01-12-2016 | Original research

For avid glucose tumors, the SUV peak is the most reliable parameter for [18F]FDG-PET/CT quantification, regardless of acquisition time

Authors: Avigaëlle Sher, Franck Lacoeuille, Pacôme Fosse, Laurent Vervueren, Aurélie Cahouet-Vannier, Djamel Dabli, Francis Bouchet, Olivier Couturier

Published in: EJNMMI Research | Issue 1/2016

Login to get access

Abstract

Background

This study is an assessment of the impact of acquisition times on SUV with [18F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors.

Methods

One hundred six [18F]FDG-PET/CT were acquired in list mode over a single-bed position (livers (n = 48) or on tumors (n = 58)). Six independent datasets of different durations were reconstructed (from 1.5 to 10 min). SUVmax (hottest voxel), SUVpeak (maximum average SUV within a 1-cm3 spherical volume), and SUVaverage were measured within a 3-cm-diameter volume of interest (VOI) in the right lobe of the liver. For [18F]FDG avid tumors (SUVmax ≥ 5), the SUVmax, SUVpeak, and SUV41% (isocontour threshold method) were computed.

Results

For tumors, SUVpeak values did not vary with acquisition time. SUVmax displayed significant differences between 1.5- and 5–10-min reconstruction times. SUV41% was the most time-dependent parameter. For the liver, the SUVaverage was the sole parameter that did not vary over time.

Conclusions

For [18F]FDG avid tumors, with short acquisition times, i.e., with new generations of PET systems, the SUVpeak may be more robust than the SUVmax. The SUVaverage over a 3-cm-diameter VOI in the right lobe of the liver appears to be a good method for a robust and reproducible assessment of the hepatic metabolism.
Literature
1.
go back to reference Lin C, Itti E, Haïoun C, Petegnief Y, Luciani A, Dupuis J, et al. Early 18F-FDG PET for prediction of prognosis in patients with diffuse large B-cell lymphoma: SUV-based assessment versus visual analysis. J Nucl Med. 2007;48:1626–32.CrossRefPubMed Lin C, Itti E, Haïoun C, Petegnief Y, Luciani A, Dupuis J, et al. Early 18F-FDG PET for prediction of prognosis in patients with diffuse large B-cell lymphoma: SUV-based assessment versus visual analysis. J Nucl Med. 2007;48:1626–32.CrossRefPubMed
2.
go back to reference Boellaard RR, Krak NCN, Hoekstra OSO, Lammertsma AAA. Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: a simulation study. J Nucl Med. 2004;45:1519–27.PubMed Boellaard RR, Krak NCN, Hoekstra OSO, Lammertsma AAA. Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: a simulation study. J Nucl Med. 2004;45:1519–27.PubMed
3.
go back to reference Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med. 2009;50 Suppl 1:122S–50S.CrossRefPubMedPubMedCentral Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med. 2009;50 Suppl 1:122S–50S.CrossRefPubMedPubMedCentral
4.
go back to reference Krak NC, Boellaard R, Hoekstra OS, Twisk JWR, Hoekstra CJ, Lammertsma AA. Effects of ROI definition and reconstruction method on quantitative outcome and applicability in a response monitoring trial. Eur J Nucl Med Mol Imaging. 2005;32:294–301.CrossRefPubMed Krak NC, Boellaard R, Hoekstra OS, Twisk JWR, Hoekstra CJ, Lammertsma AA. Effects of ROI definition and reconstruction method on quantitative outcome and applicability in a response monitoring trial. Eur J Nucl Med Mol Imaging. 2005;32:294–301.CrossRefPubMed
5.
go back to reference Nahmias C, Wahl LM. Reproducibility of standardized uptake value measurements determined by 18F-FDG PET in malignant tumors. J Nucl Med. 2008;49:1804–8.CrossRefPubMed Nahmias C, Wahl LM. Reproducibility of standardized uptake value measurements determined by 18F-FDG PET in malignant tumors. J Nucl Med. 2008;49:1804–8.CrossRefPubMed
6.
go back to reference Vanderhoek M, Perlman SB, Jeraj R. Impact of the definition of peak standardized uptake value on quantification of treatment response. J Nucl Med. 2012;53:4–11.CrossRefPubMedPubMedCentral Vanderhoek M, Perlman SB, Jeraj R. Impact of the definition of peak standardized uptake value on quantification of treatment response. J Nucl Med. 2012;53:4–11.CrossRefPubMedPubMedCentral
7.
go back to reference Murray I, Kalemis A, Glennon J, Hasan S, Quraishi S, Beyer T, et al. Time-of-flight PET/CT using low-activity protocols: potential implications for cancer therapy monitoring. Eur J Nucl Med Mol Imaging. 2010;37:1643–53.CrossRefPubMed Murray I, Kalemis A, Glennon J, Hasan S, Quraishi S, Beyer T, et al. Time-of-flight PET/CT using low-activity protocols: potential implications for cancer therapy monitoring. Eur J Nucl Med Mol Imaging. 2010;37:1643–53.CrossRefPubMed
8.
go back to reference Lasnon C, Hicks RJ, Beauregard J-M, Milner A, Paciencia M, Guizard A-V, et al. Impact of point spread function reconstruction on thoracic lymph node staging with 18F-FDG PET/CT in non-small cell lung cancer. Clin Nucl Med. 2012;37:971–6.CrossRefPubMed Lasnon C, Hicks RJ, Beauregard J-M, Milner A, Paciencia M, Guizard A-V, et al. Impact of point spread function reconstruction on thoracic lymph node staging with 18F-FDG PET/CT in non-small cell lung cancer. Clin Nucl Med. 2012;37:971–6.CrossRefPubMed
9.
go back to reference Armstrong IS, Kelly MD, Williams HA, Matthews JC. Impact of point spread function modelling and time of flight on FDG uptake measurements in lung lesions using alternative filtering strategies. EJNMMI Phys. 2014;1:99.CrossRefPubMed Armstrong IS, Kelly MD, Williams HA, Matthews JC. Impact of point spread function modelling and time of flight on FDG uptake measurements in lung lesions using alternative filtering strategies. EJNMMI Phys. 2014;1:99.CrossRefPubMed
10.
go back to reference Boellaard R, Delgado-Bolton R, Oyen WJG, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42(2):328–54.CrossRefPubMedPubMedCentral Boellaard R, Delgado-Bolton R, Oyen WJG, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42(2):328–54.CrossRefPubMedPubMedCentral
11.
go back to reference Bouchet F, Geworski L, Knoop BO, Ferrer L, Barriolo-Riedinger A, Millardet C, et al. Calibration test of PET scanners in a multi-centre clinical trial on breast cancer therapy monitoring using 18F-FLT. PLoS ONE. 2013;8:e58152.CrossRefPubMedPubMedCentral Bouchet F, Geworski L, Knoop BO, Ferrer L, Barriolo-Riedinger A, Millardet C, et al. Calibration test of PET scanners in a multi-centre clinical trial on breast cancer therapy monitoring using 18F-FLT. PLoS ONE. 2013;8:e58152.CrossRefPubMedPubMedCentral
12.
go back to reference Hoffman EJ, Huang SC, Phelps ME. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr. 1979;3:299–308.CrossRefPubMed Hoffman EJ, Huang SC, Phelps ME. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr. 1979;3:299–308.CrossRefPubMed
13.
go back to reference Kremer R, Peysakhovich Y, Dan L-F, Guralnik L, Kagna O, Nir R-R, et al. FDG PET/CT for assessing the resectability of NSCLC patients with N2 disease after neoadjuvant therapy. Ann Nucl Med. 2016;30(2):114–21.CrossRefPubMed Kremer R, Peysakhovich Y, Dan L-F, Guralnik L, Kagna O, Nir R-R, et al. FDG PET/CT for assessing the resectability of NSCLC patients with N2 disease after neoadjuvant therapy. Ann Nucl Med. 2016;30(2):114–21.CrossRefPubMed
14.
go back to reference Hachemi M, Couturier O, Vervueren L, Fosse P, Lacoeuille F, Urban T, et al. [18F]FDG positron emission tomography within two weeks of starting erlotinib therapy can predict response in non-small cell lung cancer patients. PLoS ONE. 2014;9:e87629.CrossRefPubMedPubMedCentral Hachemi M, Couturier O, Vervueren L, Fosse P, Lacoeuille F, Urban T, et al. [18F]FDG positron emission tomography within two weeks of starting erlotinib therapy can predict response in non-small cell lung cancer patients. PLoS ONE. 2014;9:e87629.CrossRefPubMedPubMedCentral
15.
go back to reference Vanderhoek M, Juckett MB, Perlman SB, Nickles RJ, Jeraj R. Early assessment of treatment response in patients with AML using [(18)F]FLT PET imaging. Leuk Res. 2011;35:310–6.CrossRefPubMedPubMedCentral Vanderhoek M, Juckett MB, Perlman SB, Nickles RJ, Jeraj R. Early assessment of treatment response in patients with AML using [(18)F]FLT PET imaging. Leuk Res. 2011;35:310–6.CrossRefPubMedPubMedCentral
16.
go back to reference Westerterp M, Pruim J, Oyen W, Hoekstra O, Paans A, Visser E, et al. Quantification of FDG PET studies using standardised uptake values in multi-centre trials: effects of image reconstruction, resolution and ROI definition parameters. Eur J Nucl Med Mol Imaging. 2007;34:392–404.CrossRefPubMed Westerterp M, Pruim J, Oyen W, Hoekstra O, Paans A, Visser E, et al. Quantification of FDG PET studies using standardised uptake values in multi-centre trials: effects of image reconstruction, resolution and ROI definition parameters. Eur J Nucl Med Mol Imaging. 2007;34:392–404.CrossRefPubMed
17.
go back to reference Brown C, Dempsey M-F, Gillen G, Elliott AT. Investigation of 18F-FDG 3D mode PET image quality versus acquisition time. Nucl Med Commun. 2010;31:254–9.CrossRefPubMed Brown C, Dempsey M-F, Gillen G, Elliott AT. Investigation of 18F-FDG 3D mode PET image quality versus acquisition time. Nucl Med Commun. 2010;31:254–9.CrossRefPubMed
18.
go back to reference Hausmann D, Dinter DJ, Sadick M, Brade J, Schoenberg SO, Büsing K. The impact of acquisition time on image quality in whole-body 18F-FDG PET/CT for cancer staging. J Nucl Med Technol. 2012;40:255–8.CrossRefPubMed Hausmann D, Dinter DJ, Sadick M, Brade J, Schoenberg SO, Büsing K. The impact of acquisition time on image quality in whole-body 18F-FDG PET/CT for cancer staging. J Nucl Med Technol. 2012;40:255–8.CrossRefPubMed
19.
go back to reference Goethals I, D’Asseler Y, Dobbeleir A, Deblaere K, Ham H. The effect of acquisition time on visual and semi-quantitative analysis of F-18 FDG-PET studies in patients with head and neck cancer. Nucl Med Commun. 2010;31:227–31.CrossRefPubMed Goethals I, D’Asseler Y, Dobbeleir A, Deblaere K, Ham H. The effect of acquisition time on visual and semi-quantitative analysis of F-18 FDG-PET studies in patients with head and neck cancer. Nucl Med Commun. 2010;31:227–31.CrossRefPubMed
20.
go back to reference Lodge MA, Chaudhry MA, Wahl RL. Noise considerations for PET quantification using maximum and peak standardized uptake value. J Nucl Med. 2012;53:1041–7.CrossRefPubMedPubMedCentral Lodge MA, Chaudhry MA, Wahl RL. Noise considerations for PET quantification using maximum and peak standardized uptake value. J Nucl Med. 2012;53:1041–7.CrossRefPubMedPubMedCentral
21.
go back to reference Boellaard R. Standards for PET image acquisition and quantitative data analysis. J Nucl Med. 2009;50:11S–20S.CrossRefPubMed Boellaard R. Standards for PET image acquisition and quantitative data analysis. J Nucl Med. 2009;50:11S–20S.CrossRefPubMed
22.
go back to reference Mathias CJ, Welch MJ, Katzenellenbogen JA, Brodack JW, Kilbourn MR, Carlson KE, et al. Characterization of the uptake of 16 alpha-([18F]fluoro)-17 beta-estradiol in DMBA-induced mammary tumors. Int J Rad Appl Instrum B. 1987;14:15–25.CrossRefPubMed Mathias CJ, Welch MJ, Katzenellenbogen JA, Brodack JW, Kilbourn MR, Carlson KE, et al. Characterization of the uptake of 16 alpha-([18F]fluoro)-17 beta-estradiol in DMBA-induced mammary tumors. Int J Rad Appl Instrum B. 1987;14:15–25.CrossRefPubMed
23.
go back to reference Viner M, Mercier G, Hao F, Malladi A, Subramaniam RM. Liver SULmean at FDG PET/CT: interreader agreement and impact of placement of volume of interest. Radiology. 2013;267:596–601.CrossRefPubMed Viner M, Mercier G, Hao F, Malladi A, Subramaniam RM. Liver SULmean at FDG PET/CT: interreader agreement and impact of placement of volume of interest. Radiology. 2013;267:596–601.CrossRefPubMed
24.
go back to reference Gordien P, Morliere C, Bordenave L, Hindie E. Variation de la captation hépatique de 18-FDG dans l’évaluation intermédiaire des lymphomes B diffus à grandes cellules en TEP/TDM. Medecine Nucleaire. 2014;38:83–90. Gordien P, Morliere C, Bordenave L, Hindie E. Variation de la captation hépatique de 18-FDG dans l’évaluation intermédiaire des lymphomes B diffus à grandes cellules en TEP/TDM. Medecine Nucleaire. 2014;38:83–90.
Metadata
Title
For avid glucose tumors, the SUV peak is the most reliable parameter for [18F]FDG-PET/CT quantification, regardless of acquisition time
Authors
Avigaëlle Sher
Franck Lacoeuille
Pacôme Fosse
Laurent Vervueren
Aurélie Cahouet-Vannier
Djamel Dabli
Francis Bouchet
Olivier Couturier
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
EJNMMI Research / Issue 1/2016
Electronic ISSN: 2191-219X
DOI
https://doi.org/10.1186/s13550-016-0177-8

Other articles of this Issue 1/2016

EJNMMI Research 1/2016 Go to the issue