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Published in: Journal of Medical Case Reports 1/2015

Open Access 01-12-2015 | Case report

Efficacy of aerobic physical retraining in a case of combined pulmonary fibrosis and emphysema syndrome: a case report

Authors: Giuseppe De Simone, Giovanna Aquino, Claudio Di Gioia, Gennaro Mazzarella, Andrea Bianco, Giuseppe Calcagno

Published in: Journal of Medical Case Reports | Issue 1/2015

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Abstract

Introduction

Combined pulmonary fibrosis and emphysema has recently been recognized as a syndrome but remains under-diagnosed. Neither clinical management nor therapeutic approaches have been clearly defined. Pulmonary rehabilitation has not been considered within the therapeutic options for combined pulmonary fibrosis and emphysema. In this case we explored the potential benefits of a specific aerobic physical retraining program in the management of combined pulmonary fibrosis and emphysema.

Case presentation

We describe the case of a 65-year-old Caucasian man with combined pulmonary fibrosis and emphysema and respiratory failure who was receiving long-term oxygen therapy. Our patient underwent physical retraining with moderate intensity aerobic and breathing exercises for four weeks. Clinical and motor tests, as well as questionnaires assessing quality of life and depression levels, were performed prior to and following the retraining. At the end of the retraining program a relevant reduction of long-term oxygen therapy requirement was registered; improvements in terms of physical performance, quality of life, and mood were observed in our patient but no change in respiratory parameters.

Conclusions

A program of aerobic physical retraining appears to be beneficial to patients with combined pulmonary fibrosis and emphysema and may be considered as an additional therapeutic option.
Literature
1.
go back to reference Cottin V, Nunes H, Brillet P. Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. Eur Respir J. 2005;26:586–93.CrossRefPubMed Cottin V, Nunes H, Brillet P. Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. Eur Respir J. 2005;26:586–93.CrossRefPubMed
3.
go back to reference Mazzarella G, Esposito V, Bianco A. Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens. Environ Pollut. 2012;161:64–9.CrossRefPubMed Mazzarella G, Esposito V, Bianco A. Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens. Environ Pollut. 2012;161:64–9.CrossRefPubMed
4.
go back to reference Esposito V, Lucariello A, Savarese L. Morphology changes in human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens. Environ Pollut. 2012;171:162–7.CrossRefPubMed Esposito V, Lucariello A, Savarese L. Morphology changes in human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens. Environ Pollut. 2012;171:162–7.CrossRefPubMed
5.
go back to reference Katzenstein AL, Mukhopadhyay S, Zanardi C. Clinically occult interstitial fibrosis in smokers: classification significance of a surprisingly common finding in lobectomy specimens. Hum Pathol. 2010;41(3):316–25.CrossRefPubMed Katzenstein AL, Mukhopadhyay S, Zanardi C. Clinically occult interstitial fibrosis in smokers: classification significance of a surprisingly common finding in lobectomy specimens. Hum Pathol. 2010;41(3):316–25.CrossRefPubMed
6.
go back to reference De Laurentiis G, Paris D, Melck D. Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate. J Proteome Res. 2013;12:1502–11.CrossRefPubMed De Laurentiis G, Paris D, Melck D. Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate. J Proteome Res. 2013;12:1502–11.CrossRefPubMed
7.
go back to reference Maldor MJ, Kufel TJ, Pineda LA. Effect of pulmonary rehabilitation on quadriceps fatigability during exercise. Am J Respir Crit Care Med. 2001;163:930–5.CrossRef Maldor MJ, Kufel TJ, Pineda LA. Effect of pulmonary rehabilitation on quadriceps fatigability during exercise. Am J Respir Crit Care Med. 2001;163:930–5.CrossRef
8.
go back to reference Decramer M. Response of the respiratory muscles to rehabilitation in COPD. J Appl Physiol. 2009;107:971–6.CrossRefPubMed Decramer M. Response of the respiratory muscles to rehabilitation in COPD. J Appl Physiol. 2009;107:971–6.CrossRefPubMed
9.
go back to reference Mereles D, Ehlken N, Kreuscher S. Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation. 2006;114:1482–9.CrossRefPubMed Mereles D, Ehlken N, Kreuscher S. Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation. 2006;114:1482–9.CrossRefPubMed
10.
go back to reference Daniele A, De Rosa A, Nigro E. Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease. Int J Biochem Cell Biol. 2012;44:563–9.CrossRefPubMed Daniele A, De Rosa A, Nigro E. Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease. Int J Biochem Cell Biol. 2012;44:563–9.CrossRefPubMed
11.
go back to reference Nigro E, Scudiero O, Sarnataro D. Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1ß toxicity through AdipoR1. Int J Biochem Cell Biol. 2013;45(6):1145–53.CrossRefPubMed Nigro E, Scudiero O, Sarnataro D. Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1ß toxicity through AdipoR1. Int J Biochem Cell Biol. 2013;45(6):1145–53.CrossRefPubMed
12.
go back to reference Corbi G, Bianco A, Turchiarelli V. Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on sirtuins. Int J Mol Sci. 2013;14(6):12696–713.CrossRefPubMedPubMedCentral Corbi G, Bianco A, Turchiarelli V. Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on sirtuins. Int J Mol Sci. 2013;14(6):12696–713.CrossRefPubMedPubMedCentral
13.
go back to reference Bianco A, Mazzarella G, Turchiarelli V. Adiponectin: an attractive marker for metabolic disorders in chronic obstructive pulmonary disease (COPD). Nutrients. 2013;5:4115–25.CrossRefPubMedPubMedCentral Bianco A, Mazzarella G, Turchiarelli V. Adiponectin: an attractive marker for metabolic disorders in chronic obstructive pulmonary disease (COPD). Nutrients. 2013;5:4115–25.CrossRefPubMedPubMedCentral
14.
15.
go back to reference Kozu R, Senjyu H, Jenkins SC. Differences in response to pulmonary rehabilitation in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Respiration. 2010;81(3):196–205.CrossRefPubMed Kozu R, Senjyu H, Jenkins SC. Differences in response to pulmonary rehabilitation in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Respiration. 2010;81(3):196–205.CrossRefPubMed
Metadata
Title
Efficacy of aerobic physical retraining in a case of combined pulmonary fibrosis and emphysema syndrome: a case report
Authors
Giuseppe De Simone
Giovanna Aquino
Claudio Di Gioia
Gennaro Mazzarella
Andrea Bianco
Giuseppe Calcagno
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2015
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-015-0570-3

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