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Molecular Autism
Published in: Molecular Autism 1/2016

Open Access 01-12-2016 | Research

Visual preference for social stimuli in individuals with autism or neurodevelopmental disorders: an eye-tracking study

Authors: Hayley Crawford, Joanna Moss, Chris Oliver, Natasha Elliott, Giles M. Anderson, Joseph P. McCleery

Published in: Molecular Autism | Issue 1/2016

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Abstract

Background

Recent research has identified differences in relative attention to competing social versus non-social video stimuli in individuals with autism spectrum disorder (ASD). Whether attentional allocation is influenced by the potential threat of stimuli has yet to be investigated. This is manipulated in the current study by the extent to which the stimuli are moving towards or moving past the viewer. Furthermore, little is known about whether such differences exist across other neurodevelopmental disorders. This study aims to determine if adolescents with ASD demonstrate differences in attentional allocation to competing pairs of social and non-social video stimuli, where the actor or object either moves towards or moves past the viewer, in comparison to individuals without ASD, and to determine if individuals with three genetic syndromes associated with differing social phenotypes demonstrate differences in attentional allocation to the same stimuli.

Methods

In study 1, adolescents with ASD and control participants were presented with social and non-social video stimuli in two formats (moving towards or moving past the viewer) whilst their eye movements were recorded. This paradigm was then employed with groups of individuals with fragile X, Cornelia de Lange, and Rubinstein-Taybi syndromes who were matched with one another on chronological age, global adaptive behaviour, and verbal adaptive behaviour (study 2).

Results

Adolescents with ASD demonstrated reduced looking-time to social versus non-social videos only when stimuli were moving towards them. Individuals in the three genetic syndrome groups showed similar looking-time but differences in fixation latency for social stimuli moving towards them. Across both studies, we observed within- and between-group differences in attention to social stimuli that were moving towards versus moving past the viewer.

Conclusions

Taken together, these results provide strong evidence to suggest differential visual attention to competing social versus non-social video stimuli in populations with clinically relevant, genetically mediated differences in socio-behavioural phenotypes.
Literature
1.
Riby DM, Hancock PJB. Do faces capture the attention of individuals with Williams syndrome or autism? Evidence from tracking eye movements. J Autism Dev Disord. 2009;39(3):421–31.CrossRefPubMed
2.
Riby DM, Doherty-Sneddon G, Bruce V. The eyes or the mouth? Feature salience and unfamiliar face processing in Williams syndrome and autism. Q J Exp Psychol. 2009;62(1):189–203.CrossRef
3.
Riby DM, Hancock PJB. Looking at movies and cartoons: eye-tracking evidence from Williams syndrome and autism. J Intellect Disabil Res. 2009;53(2):169–81.CrossRefPubMed
4.
Riby DM, Hancock PJB. Viewing it differently: social scene perception in Williams syndrome and autism. Neuropsychologia. 2008;46(11):2855–60.CrossRefPubMed
5.
Kirchner JC, Hatri A, Heekeren HR, Dziobeck I. Autistic symptomatology, face processing abilities, and eye fixation patterns. J Autism Dev Disord. 2011;41(2):158–67.CrossRefPubMed
6.
Klin A, Jones W, Schultz R, Volkmar F, Cohen D. Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism. Arch Gen Psychiatry. 2002;59(9):809–16.CrossRefPubMed
7.
Speer LL, Cook AE, McMahon WM, Clark E. Face processing in children with autism effects of stimulus contents and type. Autism. 2007;11(3):265–77.CrossRefPubMed
8.
Kliemann D, Dziobeck I, Hatri A, Steimke R, Heekeren HR. Atypical reflexive gaze patterns on emotional faces in autism spectrum disorders. J Neurosci. 2010;30(37):12281–7.CrossRefPubMed
9.
Pierce K, Conant D, Hazin R, Stoner R, Desmond J. Preference for geometric patterns early in life as a risk factor for autism. Arch Gen Psychiatry. 2011;68(1):101–9.CrossRefPubMed
10.
Klin A, Lin DJ, Gorrindo P, Ramsay G, Jones W. Two-year-olds with autism orient to nonsocial contingencies rather than biological motion. Nature. 2009;459(7244):257–61.CrossRefPubMedPubMedCentral
11.
Fletcher-Watson S, Leekam SR, Benson V, Frank MC, Findlay JM. Eye-movements reveal attention to social information in autism spectrum disorder. Neuropsychologia. 2009;47(1):248–57.CrossRefPubMed
12.
Sasson NJ, Touchstone EW. Visual attention to competing social and object images by preschool children with autism spectrum disorder. J Autism Dev Disord. 2013;44(3):584–92.CrossRef
13.
Chevallier C, Parish-Morris J, McVey A, Rump KM, Sasson NJ, Herrington JD, et al. Measuring social attention and motivation in autism spectrum disorder using eye-tracking: stimulus type matters. Autism Res. 2015. doi:10.​1002/​aur.​1479.PubMed
14.
15.
Heenan A, Troje NF. Both physical exercise and progressive muscle relaxation reduce the facing-the-viewer bias in biological perception. PLoS ONE. 2014;9(7):e99902.CrossRefPubMedPubMedCentral
16.
Armstrong T, Olatunji BO. Eye tracking of attention in the affective disorders: a meta-analytic review and synthesis. Clin Psychol Rev. 2012;32(8):704–23.CrossRefPubMedPubMedCentral
17.
Chawarska K, Macari S, Shic F. Context modulates attention to social scenes in toddlers with autism. J Child Psychol Psychiatry. 2012;53(8):903–13.CrossRefPubMed
18.
Pitskel NB, Bolling DZ, Hudac CM, Lantz SD, Minshew NJ, Vander Wyc BC, et al. Brain mechanisms for processing direct and averted gaze in individuals with autism. J Autism Dev Disord. 2011;41(12):1686–93.CrossRefPubMedPubMedCentral
19.
Riby DM, Doherty-Sneddon G, Bruce V. Exploring face perception in disorders of development: evidence from Williams syndrome and autism. J Neuropsychol. 2008;2(1):47–64.CrossRefPubMed
20.
21.
22.
Turner G, Webb T, Wake S, Robinson H. Prevalence of fragile X syndrome. Am J Med Genet. 1996;64(1):196–7.CrossRefPubMed
23.
Cordeiro L, Ballinger E, Hagerman R, Hessl D. Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: prevalence and characterization. J Neurodev Disord. 2011;3(1):57–67.CrossRefPubMedPubMedCentral
24.
Merenstein SA, Sobesky WE, Taylor AK, Riddle JE, Tran HX, Hagerman R. Molecular-clinical correlations in males with an expanded FMR1 mutation. Am J Med Genet. 1996;64(2):388–94.CrossRefPubMed
25.
Roberts JE, Weisenfeld LAH, Hatton DD, Heath M, Kaufmann WE. Social approach and autistic behavior in children with fragile X syndrome. J Autism Dev Disord. 2007;37(9):1748–60.CrossRefPubMed
26.
Kau ASM, Reider EE, Payne L, Meyer WA, Freund LS. Early behavior signs of psychiatric phenotypes in fragile X syndrome. Am J Ment Retard. 2000;105(4):286–99.CrossRefPubMed
27.
Clifford S, Dissanayake C, Bui QM, Huggins R, Taylor AK, Loesch DZ. Autism spectrum phenotype in males and females with fragile X full mutation and premutation. J Autism Dev Disord. 2007;37(4):738–47.CrossRefPubMed
28.
Beck B. Epidemiology of Cornelia de Lange’s syndrome. Acta Paediatr. 1976;65(4):631–8.CrossRef
29.
Goodban MT. Survey of speech and language skills with prognostic indicators in 116 patients with Cornelia de Lange syndrome. Am J Med Genet. 1993;47(7):1059–63.CrossRefPubMed
30.
Collis L, Oliver C, Moss J. Low mood and social anxiety in Cornelia de Lange syndrome. J Intellect Disabil Res. 2006;50:792.
31.
Moss J, Oliver C, Berg K, Kaur G, Jephcott L, Cornish K. Prevalence of autism spectrum phenomenology in Cornelia de Lange and Cri du Chat syndromes. Am J Ment Retard. 2008;113(4):278–91.CrossRefPubMed
32.
Richards C, Moss J, O’Farrell L, Kaur G, Oliver C. Social anxiety in Cornelia de Lange syndrome. J Autism Dev Disord. 2009;39(8):1155–62.CrossRefPubMed
33.
Hennekam RC, Van Den Boogaard M-J, Sibbles BJ, Van Spijker HG. Rubinstein-Taybi syndrome in the Netherlands. Am J Med Genet. 1990;37(56):17–29.
34.
Galéra C, Taupiac E, Fraisse S, Naudion S, Toussaint E, Rooryck-Thambo C, et al. Socio-behavioral characteristics of children with Rubinstein-Taybi syndrome. J Autism Dev Disord. 2009;39(9):1252–60.CrossRefPubMed
35.
Williams TA, Porter MA, Langdon R. Viewing social scenes: a visual scan-path study comparing fragile X syndrome and Williams syndrome. J Autism Dev Disord. 2013;43(8):1880–94.CrossRefPubMed
36.
Dalton KM, Holsen L, Abbeduto L, Davidson RJ. Brain function and gaze fixation during facial-emotion processing in fragile X and autism. Autism Res. 2008;1(4):231–9.CrossRefPubMedPubMedCentral
37.
Holsen LM, Dalton KM, Johnstone T, Davidson RJ. Prefrontal social cognition network dysfunction underlying face encoding and social anxiety in fragile X syndrome. Neuroimage. 2008;43(3):592–604.CrossRefPubMedPubMedCentral
38.
Farzin F, Rivera SM, Hessl D. Brief report: visual processing of faces in individuals with fragile X syndrome: an eye tracking study. J Autism Dev Disord. 2009;39(6):946–52.CrossRefPubMedPubMedCentral
39.
Crawford H, Moss J, Anderson GM, Oliver C, McCleery JP. Implicit discrimination of basic facial expressions of positive/negative emotion in fragile X syndrome and autism spectrum disorder. Am J Intellect Dev Disabil. 2015;120(40):328–45.CrossRefPubMed
40.
Shaw TA, Porter MA. Emotion recognition and visual-scan paths in fragile X syndrome. J Autism Dev Disord. 2013;43(5):1119–39.CrossRefPubMed
41.
Crawford H, Moss J, McCleery JP, Anderson GM, Oliver C. Face scanning and spontaneous emotion preference in Cornelia de Lange syndrome and Rubinstein-Taybi syndrome. J Neurodev Disord. 2015;7:22.CrossRefPubMedPubMedCentral
42.
Sparrow SS, Cicchetti DV, Balla DA. Vineland-II adaptive behavior scales: survey forms manual. Circle Pines, MN: AGS Publishing; 2005.
43.
Lord C, Rutter M, DiLavore P, Risi S. Autism diagnostic observation schedule: manual. Los Angeles, CA: Western Psychological Services; 2002.
44.
Elliot C, Smith P, McCulloch K. British ability scales—second edition. Administration and scoring manual. Windsor, UK: NFER; 1996.
45.
Rutter M, Bailey A, Lord C. The social communication questionnaire. Los Angeles, CA: Western Psychological Services; 2003.
46.
47.
Moss J, Oliver C, Nelson L, Richards C, Hall S. Delineating the profile of autism spectrum disorder characteristics in Cornelia de Lange and fragile X syndromes. Am J Intellect Dev Disabil. 2013;118(1):55–73.CrossRefPubMed
48.
Moss J, Howlin P, Magiati I, Oliver C. Characteristics of autism spectrum disorder in Cornelia de Lange syndrome. J Child Psychol Psychiatry. 2012;53(8):883–91.CrossRefPubMed
49.
Hennekam RC, Baselier AC, Beyaert E, Bos A. Psychological and speech studies in Rubinstein-Taybi syndrome. Am J Ment Retard. 1992;96(6):645–60.PubMed
50.
Metadata
Title
Visual preference for social stimuli in individuals with autism or neurodevelopmental disorders: an eye-tracking study
Authors
Hayley Crawford
Joanna Moss
Chris Oliver
Natasha Elliott
Giles M. Anderson
Joseph P. McCleery
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Molecular Autism / Issue 1/2016
Electronic ISSN: 2040-2392
DOI
https://doi.org/10.1186/s13229-016-0084-x

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