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Trials
Published in: Trials 1/2018

Open Access 01-12-2018 | Study protocol

Physical Rehabilitation Core Outcomes In Critical illness (PRACTICE): protocol for development of a core outcome set

Authors: Bronwen Connolly, Linda Denehy, Nicholas Hart, Natalie Pattison, Paula Williamson, Bronagh Blackwood

Published in: Trials | Issue 1/2018

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Abstract

Background

Existing data on physical rehabilitation interventions in critical illness are challenged by outcome heterogeneity that limits data synthesis and translation of research findings into clinical practice. This protocol describes the PRACTICE study to develop a core outcome set (COS) for trials of physical rehabilitation interventions delivered across the continuum of a patient’s recovery from the intensive care unit until reintegration in the community following hospital discharge.

Methods

Mixed methods will be used including: systematic reviews of quantitative and qualitative literature; qualitative interviews with patients and caregivers; a modified Delphi consensus process with researcher, clinician and patient/caregiver stakeholder groups; and consensus meetings for ratification of findings, resolving uncertainty, or developing an action plan for COS implementation.

Discussion

The PRACTICE COS will inform relevant stakeholders about important outcomes regarding physical rehabilitation in critical illness, and may enhance the future design and conduct of trials in this area.

Trial registration

COMET database (www.​comet-initiative.​org/​, Record ID 288, 01/03/13). PROSPERO database (CRD42014008908, CRD42017078549).
Appendix
Available only for authorised users
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Metadata
Title
Physical Rehabilitation Core Outcomes In Critical illness (PRACTICE): protocol for development of a core outcome set
Authors
Bronwen Connolly
Linda Denehy
Nicholas Hart
Natalie Pattison
Paula Williamson
Bronagh Blackwood
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Trials / Issue 1/2018
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-018-2678-4

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