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Critical Care
Published in: Critical Care 1/2023

Open Access 01-12-2023 | ECMO | Comment

Beta-blockers in refractory hypoxemia on venovenous extracorporeal membrane oxygenation: a double-edged sword

Authors: Dawid L. Staudacher, Tobias Wengenmayer, Matthieu Schmidt

Published in: Critical Care | Issue 1/2023

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Excerpt

Up to 10% of patients admitted to the intensive care unit (ICU) suffer from acute respiratory distress syndrome (ARDS) [1]. Severe respiratory failure can result in refractory hypoxemia, characterized by diminished arterial oxygen content and subsequent tissue hypoxia [2]. To address hypoxia, venovenous extracorporeal membrane oxygenation (V-V ECMO) can be employed, delivering up to 6–7 L per minute of fully oxygenated blood to the venous circulation [2, 3]. …
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Ramanathan K, Shekar K, Ling RR, Barbaro RP, Wong SN, Tan CS, Rochwerg B, Fernando SM, Takeda S, MacLaren G, et al. Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Crit Care. 2021;25(1):211.CrossRefPubMedPubMedCentral
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Levy B, Taccone FS, Guarracino F. Recent developments in the management of persistent hypoxemia under veno-venous ECMO. Intensive Care Med. 2015;41(3):508–10.CrossRefPubMed
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Zakhary B, Vercaemst L, Mason P, Lorusso R, Brodie D. How I manage drainage insufficiency on extracorporeal membrane oxygenation. Crit Care. 2020;24(1):151.CrossRefPubMedPubMedCentral
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Bunge JJH, Diaby S, Valle AL, Bakker J, Gommers D, Vincent JL, Creteur J, Taccone FS, Reis Miranda D. Safety and efficacy of beta-blockers to improve oxygenation in patients on veno-venous ECMO. J Crit Care. 2019;53:248–52.CrossRefPubMed
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Guarracino F, Zangrillo A, Ruggeri L, Pieri M, Calabrò MG, Landoni G, Stefani M, Doroni L, Pappalardo F. β-Blockers to optimize peripheral oxygenation during extracorporeal membrane oxygenation: a case series. J Cardiothorac Vasc Anesth. 2012;26(1):58–63.CrossRefPubMed
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Broaddus VC, Ernst JD, King Jr TE, Lazarus SC, Sarmiento K, Schnapp L, Stapleton RD, Gotway MB: Murray & Nadel's textbook of respiratory medicine: Elsevier Health Sciences; 2021.
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Schmidt M, Tachon G, Devilliers C, Muller G, Hekimian G, Bréchot N, Merceron S, Luyt CE, Trouillet JL, Chastre J, et al. Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults. Intensive Care Med. 2013;39(5):838–46.CrossRefPubMed
Metadata
Title
Beta-blockers in refractory hypoxemia on venovenous extracorporeal membrane oxygenation: a double-edged sword
Authors
Dawid L. Staudacher
Tobias Wengenmayer
Matthieu Schmidt
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2023
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-023-04648-7

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