Skip to main content
Top
Published in: Critical Care 1/2020

Open Access 01-12-2020 | COVID-19 | Research Letter

Incidence and mortality of pulmonary embolism in COVID-19: a systematic review and meta-analysis

Authors: Shu-Chen Liao, Shih-Chieh Shao, Yih-Ting Chen, Yung-Chang Chen, Ming-Jui Hung

Published in: Critical Care | Issue 1/2020

Login to get access

Excerpt

Coronavirus disease 2019 (COVID-19) remains an increasing global pandemic, with significant morbidity and mortality. Severe complications of COVID-19 associated with coagulation changes, mainly characterized by increased D-dimer and fibrinogen levels with higher thrombosis risk, in particular pulmonary embolism (PE), have been reported recently [1]. However, the epidemiology of PE among COVID-19 patients is currently only based on small case series and retrospective studies. This systematic review and meta-analysis addresses this gap in knowledge, facilitating first-line healthcare providers’ understanding of PE incidence and mortality in COVID-19. …
Literature
1.
go back to reference Susen S, Tacquard CA, Godon A, Mansour A, Garrigue D, Nguyen P, et al. Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring. Crit Care. 2020;24(1):364.PubMedPubMedCentralCrossRef Susen S, Tacquard CA, Godon A, Mansour A, Garrigue D, Nguyen P, et al. Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring. Crit Care. 2020;24(1):364.PubMedPubMedCentralCrossRef
2.
go back to reference Wang Y, Zhang D, Du G, Du R, Zhao J, Jin Y, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. 2020;395(10236):1569–1578.PubMedPubMedCentralCrossRef Wang Y, Zhang D, Du G, Du R, Zhao J, Jin Y, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet. 2020;395(10236):1569–1578.PubMedPubMedCentralCrossRef
3.
go back to reference Riker RR, May TL, Fraser GL, Gagnon DJ, Bandara M, Zemrak WR, et al. Heparin-induced Thrombocytopenia with Thrombosis in COVID-19 Adult Respiratory Distress Syndrome. Res Pract Thromb Haemost. 2020;4:936–941.PubMedCrossRef Riker RR, May TL, Fraser GL, Gagnon DJ, Bandara M, Zemrak WR, et al. Heparin-induced Thrombocytopenia with Thrombosis in COVID-19 Adult Respiratory Distress Syndrome. Res Pract Thromb Haemost. 2020;4:936–941.PubMedCrossRef
5.
go back to reference Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, et al. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19. Ann Intern Med. 2020;M20-2003. Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, et al. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19. Ann Intern Med. 2020;M20-2003.
6.
go back to reference Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers D, Kant KM, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thromb Res. 2020;191:148–150.PubMedPubMedCentralCrossRef Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers D, Kant KM, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thromb Res. 2020;191:148–150.PubMedPubMedCentralCrossRef
7.
go back to reference Llitjos JF, Leclerc M, Chochois C, Monsallier JM, Ramakers M, Auvray M, et al. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. J Thromb Haemost. 2020;18(7):1743–1746.PubMedCrossRef Llitjos JF, Leclerc M, Chochois C, Monsallier JM, Ramakers M, Auvray M, et al. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. J Thromb Haemost. 2020;18(7):1743–1746.PubMedCrossRef
8.
go back to reference Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X, et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020;46(6):1089–1098.PubMedCrossRef Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X, et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020;46(6):1089–1098.PubMedCrossRef
9.
go back to reference Menter T, Haslbauer JD, Nienhold R, Savic S, Deigendesch H, Frank S, et al. Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology. 2020; https://doi.org/10.1111/his.14134.PubMedCrossRef Menter T, Haslbauer JD, Nienhold R, Savic S, Deigendesch H, Frank S, et al. Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology. 2020; https://​doi.​org/​10.​1111/​his.​14134.PubMedCrossRef
10.
go back to reference Bompard F, Monnier H, Saab I, Tordjman M, Abdoul H, Fournier L, et al. Pulmonary embolism in patients with Covid-19 pneumonia. Eur Respir J. 2020;2001365. Bompard F, Monnier H, Saab I, Tordjman M, Abdoul H, Fournier L, et al. Pulmonary embolism in patients with Covid-19 pneumonia. Eur Respir J. 2020;2001365.
11.
go back to reference Hékimian G, Lebreton G, Bréchot N, Luyt CE, Schmidt M, Combes A. Severe pulmonary embolism in COVID-19 patients: a call for increased awareness. Crit Care. 2020;24(1):274.PubMedPubMedCentralCrossRef Hékimian G, Lebreton G, Bréchot N, Luyt CE, Schmidt M, Combes A. Severe pulmonary embolism in COVID-19 patients: a call for increased awareness. Crit Care. 2020;24(1):274.PubMedPubMedCentralCrossRef
12.
go back to reference Artifoni M, Danic G, Gautier G, Gicquel P, Boutoille D, Raffi F, et al. Systematic assessment of venous thromboembolism in COVID 19 patients receiving thromboprophylaxis: incidence and role of D dimer as predictive factors. Journal of Thrombosis and Thrombolysis. 2020;50(1):211–216.PubMedCrossRef Artifoni M, Danic G, Gautier G, Gicquel P, Boutoille D, Raffi F, et al. Systematic assessment of venous thromboembolism in COVID 19 patients receiving thromboprophylaxis: incidence and role of D dimer as predictive factors. Journal of Thrombosis and Thrombolysis. 2020;50(1):211–216.PubMedCrossRef
13.
go back to reference Fraissé M, Logre E, Pajot O, Mentec H, Plantefève G, Contou D. Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study. Crit Care. 2020;24(1):275.PubMedPubMedCentralCrossRef Fraissé M, Logre E, Pajot O, Mentec H, Plantefève G, Contou D. Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study. Crit Care. 2020;24(1):275.PubMedPubMedCentralCrossRef
14.
go back to reference Thomas W, Varley J, Johnston A, Symington E, Robinson M, Sheares K, et al. Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom. Thromb Res. 2020;191:76–77.PubMedPubMedCentralCrossRef Thomas W, Varley J, Johnston A, Symington E, Robinson M, Sheares K, et al. Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom. Thromb Res. 2020;191:76–77.PubMedPubMedCentralCrossRef
15.
go back to reference Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9–14.PubMedCrossRef Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9–14.PubMedCrossRef
16.
go back to reference Poissy J, Goutay J, Caplan M, Parmentier E, Duburcq T, Lassalle F, et al. Pulmonary Embolism in Patients With COVID-19: Awareness of an increased prevalence. Circulation. 2020;142(2):184–186.PubMedCrossRef Poissy J, Goutay J, Caplan M, Parmentier E, Duburcq T, Lassalle F, et al. Pulmonary Embolism in Patients With COVID-19: Awareness of an increased prevalence. Circulation. 2020;142(2):184–186.PubMedCrossRef
17.
go back to reference Gervaise A, Bouzad C, Peroux E, Helissey C. Acute pulmonary embolism in non-hospitalized COVID-19 patients referred to CTPA by emergency department. Eur Radiol. 2020;1-8. Gervaise A, Bouzad C, Peroux E, Helissey C. Acute pulmonary embolism in non-hospitalized COVID-19 patients referred to CTPA by emergency department. Eur Radiol. 2020;1-8.
18.
go back to reference Longchamp A, Longchamp J, Manzocchi‐Besson S, Whiting L, Haller C, Jeanneret S, et al. Venous thromboembolism in critically Ill patients with COVID‐19: Results of a screening study for deep vein thrombosis. Res Pract Thromb Haemost. 2020;4(5):842–7.PubMedCrossRef Longchamp A, Longchamp J, Manzocchi‐Besson S, Whiting L, Haller C, Jeanneret S, et al. Venous thromboembolism in critically Ill patients with COVID‐19: Results of a screening study for deep vein thrombosis. Res Pract Thromb Haemost. 2020;4(5):842–7.PubMedCrossRef
19.
go back to reference Leonard-Lorant I, Delabranche X, Severac F, Helms J, Pauzet C, Collange O, et al. Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship to D-dimer levels. Radiology. 2020;201561. Leonard-Lorant I, Delabranche X, Severac F, Helms J, Pauzet C, Collange O, et al. Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship to D-dimer levels. Radiology. 2020;201561.
20.
go back to reference Grillet F, Behr J, Calame P, Aubry S, Delabrousse E. Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT angiography. Radiology. 2020;201544. Grillet F, Behr J, Calame P, Aubry S, Delabrousse E. Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT angiography. Radiology. 2020;201544.
21.
go back to reference Rothberg MB, Haessler SD. Complications of seasonal and pandemic influenza. Crit Care Med. 2010;38(4 Suppl):e91–7.PubMedCrossRef Rothberg MB, Haessler SD. Complications of seasonal and pandemic influenza. Crit Care Med. 2010;38(4 Suppl):e91–7.PubMedCrossRef
22.
go back to reference Bikdeli B, Wang Y, Jimenez D, Parikh SA, Monreal M, Goldhaber SZ, et al. Pulmonary embolism hospitalization, readmission, and mortality rates in US older adults, 1999-2015. JAMA. 2019;322(6):574–6.PubMedPubMedCentralCrossRef Bikdeli B, Wang Y, Jimenez D, Parikh SA, Monreal M, Goldhaber SZ, et al. Pulmonary embolism hospitalization, readmission, and mortality rates in US older adults, 1999-2015. JAMA. 2019;322(6):574–6.PubMedPubMedCentralCrossRef
23.
24.
go back to reference Zhai Z, Li C, Chen Y, Gerotziafas G, Zhang Z, Wan J, et al. Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines. Thromb Haemost. 2020;120(6):937–48.PubMedPubMedCentralCrossRef Zhai Z, Li C, Chen Y, Gerotziafas G, Zhang Z, Wan J, et al. Prevention and treatment of venous thromboembolism associated with coronavirus disease 2019 infection: a consensus statement before guidelines. Thromb Haemost. 2020;120(6):937–48.PubMedPubMedCentralCrossRef
Metadata
Title
Incidence and mortality of pulmonary embolism in COVID-19: a systematic review and meta-analysis
Authors
Shu-Chen Liao
Shih-Chieh Shao
Yih-Ting Chen
Yung-Chang Chen
Ming-Jui Hung
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
COVID-19
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03175-z

Other articles of this Issue 1/2020

Critical Care 1/2020 Go to the issue