Skip to main content
Top
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Editorial

Non-antibiotic treatments for bacterial diseases in an era of progressive antibiotic resistance

Author: Steven M. Opal

Published in: Critical Care | Issue 1/2016

Login to get access

Abstract

The emergence of multi-drug resistant (MDR) microbial pathogens threatens the very foundation upon which standard antibacterial chemotherapy is based. We must consider non-antibiotic solutions to manage invasive bacterial infections. Transition from antibiotics to non-traditional treatments poses real clinical challenges that will not be easy to solve. Antibiotics will continue to reliably treat some infections (e.g., group A streptococci and Treponema pallidum) but will likely need adjuvant therapies or will need to be replaced for many bacterial infections in the future.
Literature
1.
go back to reference Rolain JM, Parola P, Cornaglia C. New Delhi metallo-beta lactamase (NDM-1): towards a new pandemic? Clin Microbial Infect. 2010;16(12):1699–76.CrossRef Rolain JM, Parola P, Cornaglia C. New Delhi metallo-beta lactamase (NDM-1): towards a new pandemic? Clin Microbial Infect. 2010;16(12):1699–76.CrossRef
2.
go back to reference Liu Y-Y, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism, MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):160–8. Liu Y-Y, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism, MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):160–8.
3.
go back to reference McCrea K, Ward R, LaRosa S. Removal of carbapenem-resistant Enterobacteriaceae (CRE) from blood by heparin-functional hemoperfusion media. PLoS One. 2014;9(12), e114242.CrossRefPubMedPubMedCentral McCrea K, Ward R, LaRosa S. Removal of carbapenem-resistant Enterobacteriaceae (CRE) from blood by heparin-functional hemoperfusion media. PLoS One. 2014;9(12), e114242.CrossRefPubMedPubMedCentral
4.
go back to reference Kang JH, Super M, Yung CW, et al. An extracorporeal blood-cleaning device for sepsis therapy. Nat Med. 2014;20:1211–6.CrossRefPubMed Kang JH, Super M, Yung CW, et al. An extracorporeal blood-cleaning device for sepsis therapy. Nat Med. 2014;20:1211–6.CrossRefPubMed
5.
go back to reference Brackman G, Coenye T. Quorum sensing inhibitors as anti-biofilm agents. Curr Pharm Des. 2015;21(1):5–11.CrossRefPubMed Brackman G, Coenye T. Quorum sensing inhibitors as anti-biofilm agents. Curr Pharm Des. 2015;21(1):5–11.CrossRefPubMed
7.
go back to reference Wright A, Hawkins CH, Anggard EE, Harper DR. A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin Otolaryngol. 2009;34(4):349–57.CrossRefPubMed Wright A, Hawkins CH, Anggard EE, Harper DR. A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin Otolaryngol. 2009;34(4):349–57.CrossRefPubMed
8.
go back to reference Wittebole X, De Roock S, Opal S. A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence. 2014;5(1):226–35.CrossRefPubMed Wittebole X, De Roock S, Opal S. A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence. 2014;5(1):226–35.CrossRefPubMed
9.
go back to reference Irani V, Guy A, Andrew D, et al. Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases. Mole Immun. 2015;67:171–82.CrossRef Irani V, Guy A, Andrew D, et al. Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases. Mole Immun. 2015;67:171–82.CrossRef
10.
go back to reference Lu Q, Rouby JJ, Laterre PF, et al. Pharmacokinetics and safety of panobacumab: specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa 011 pneumonia. J Antimicrob Chemother. 2011;66(5):1110–6.CrossRefPubMed Lu Q, Rouby JJ, Laterre PF, et al. Pharmacokinetics and safety of panobacumab: specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa 011 pneumonia. J Antimicrob Chemother. 2011;66(5):1110–6.CrossRefPubMed
11.
go back to reference Luke T, Wu H, Zhao J, et al. Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoA in vivo. Sci Transl Med. 2016;8(326):326ra21.CrossRefPubMed Luke T, Wu H, Zhao J, et al. Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoA in vivo. Sci Transl Med. 2016;8(326):326ra21.CrossRefPubMed
13.
go back to reference Henry B, Neill D, Becker K, et al. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nat Biotechnol. 2015;33(1):81–8.CrossRefPubMed Henry B, Neill D, Becker K, et al. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nat Biotechnol. 2015;33(1):81–8.CrossRefPubMed
15.
go back to reference Rassmussen AL, Okumura A, Ferris MT, et al. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science. 2014;346(6212):987–91.CrossRef Rassmussen AL, Okumura A, Ferris MT, et al. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science. 2014;346(6212):987–91.CrossRef
Metadata
Title
Non-antibiotic treatments for bacterial diseases in an era of progressive antibiotic resistance
Author
Steven M. Opal
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1549-1

Other articles of this Issue 1/2016

Critical Care 1/2016 Go to the issue