Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Research

Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and network meta-analysis

Authors: Changsong Wang, Libo Guo, Chunjie Chi, Xiaoyang Wang, Lei Guo, Weiwei Wang, Nana Zhao, Yibo Wang, Zhaodi Zhang, Enyou Li

Published in: Critical Care | Issue 1/2015

Login to get access

Abstract

Introduction

The effects of different mechanical ventilation (MV) modes on mortality outcome in infants with respiratory distress syndrome (RDS) are not well known.

Methods

We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, EMBASE, MEDLINE, CINAHL, and Web of Science for studies published through April 2014 that assessed mortality in infants with RDS given different MV modes. We assessed studies for eligibility, extracted data, and subsequently pooled the data. A Bayesian fixed-effects model was used to combine direct comparisons with indirect evidence. We also performed sensitivity analyses and rankings of the competing treatment modes.

Results

In total, 20 randomized controlled trials were included for the network meta-analysis, which consisted of 2,832 patients who received one of 16 ventilation modes. Compared with synchronized intermittent mandatory ventilation (SIMV) + pressure support ventilation (PSV), time-cycled pressure-limited ventilation (TCPL) (hazard ratio (HR) 0.290; 95% confidence interval (CI) 0.071 to 0.972), high-frequency oscillatory ventilation (HFOV) (HR 0.294; 95% CI 0.080 to 0.852), SIMV + volume-guarantee (VG) (HR 0.122; 95% CI 0.014 to 0.858), and volume-controlled (V-C) (HR 0.139; 95% CI 0.024 to 0.677) ventilation modes are associated with lower mortality. The combined results of available ventilation modes were not significantly different in regard to the incidences of patent ductus arteriosus and intraventricular hemorrhage.

Conclusion

Compared with the SIMV + PSV ventilation mode, the TCPL, HFOV, SIMV + VG, and V-C ventilation modes are associated with lower mortality.
Appendix
Available only for authorised users
Literature
1.
Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, et al. European Association of Perinatal Medicine. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants–2013 update. Neonatology. 2013;103:353–68.PubMed
2.
Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, et al. European Association of Perinatal Medicine. European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants - 2010 update.Neonatology. 2010;97:402–417.
3.
Perelman RH, Farrell PM. Analysis of causes of neonatal death in the United States with specific emphasis on fatal hyaline membrane disease. Pediatrics. 1982;70:570–5.PubMed
4.
Mahmoud RA, Roehr CC, Schmalisch G. Current methods of non-invasive ventilatory support for infants. Paediatr Respir Rev. 2011;12:196–205.PubMed
5.
Morley CJ, Davis PG, Doyle LW, Brion LP, Hascoet JM, Carlin JB, et al. Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med. 2008;14:700–8.
6.
Singh SN, Malik GK, Prashanth GP, Singh A, Kumar M. High frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation in preterm infants with hyaline membrane disease: a randomized controlled trial. Indian Pediatr. 2012;49:405–8.PubMed
7.
Lista G, Castoldi F, Bianchi S, Battaglioli M, Cavigioli F, Bosoni MA. Volume guarantee versus high-frequency ventilation: lung inflammation in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2008;93:252–6.
8.
Bhuta T, Henderson-Smart DJ. Elective high frequency jet ventilation versus conventional ventilation for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev. 2000;2:CD000328.
9.
Haas DM, Caldwell DM, Kirkpatrick P, McIntosh JJ, Welton NJ. Tocolytic therapy for preterm delivery: systematic review and network meta-analysis. BMJ. 2012;345:e6226.PubMedPubMedCentral
10.
Duman N, Tuzun F, Sutcuoglu S, Yesilirmak CD, Kumral A, Ozkan H. Impact of volume guarantee on synchronized ventilation in preterm infants: a randomized controlled trial. Intensive Care Med. 2012;38:1358–64.PubMed
11.
Sinha SK, Donn SM, Gavey J, McCarty M. Randomised trial of volume controlled versus time cycled, pressure limited ventilation in preterm infants with respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed. 1997;77:F202–5.PubMedPubMedCentral
12.
Guven S, Bozdag S, Saner H, Cetinkaya M, Yazar AS, Erguven M. Early neonatal outcomes of volume guaranteed ventilation in preterm infants with respiratory distress syndrome. J Mater Fetal Neonatal Med. 2013;26:396–401.
13.
Mills EJ, Bansback N, Ghement I, Thorlund K, Kelly S, Puhan MA, et al. Multiple treatment comparison meta-analyses: a step forward into complexity. Clin Epidemiol. 2011;3:193–202.PubMedPubMedCentral
14.
Mills EJ, Thorlund K, Ioannidis JP. Demystifying trial networks and network meta-analysis. BMJ. 2013;14:f2914.
15.
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;21:e1000097.
16.
Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529–34.PubMed
17.
Salanti G, Higgins JP, Ades AE, Ioannidis JP. Evaluation of networks of randomized trials. Stat Methods Med Res. 2008;17:279–301.PubMed
18.
van Valkenhoef G, Lu G, de Brock B. Automating network meta-analysis. Res Syn Meth. 2012;3:285–99.
19.
Woods BS, Hawkins N, Scott DA. Network meta-analysis on the log-hazard scale, combining count and hazard ratio statistics accounting for multi-arm trials: a tutorial. BMC Med Res Methodol. 2010;10:54.PubMedPubMedCentral
20.
Dogliotti A, Paolasso E, Giugliano RP. Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients. Heart. 2014;100:396–405.PubMed
21.
Dias S, Sutton AJ, Ades AE, Welton NJ. Evidence synthesis for decision making 2: a generalized linear modeling framework for pairwise and network meta-analysis of randomized controlled trials. Med Decis Making. 2013;33:607–17.PubMedPubMedCentral
22.
Simillis C, Li T, Vaughan J, Becker LA, Davidson BR, Gurusamy KS. Methods to decrease blood loss during liver resection: a network meta-analysis. Cochrane Database Syst Rev. 2014;4:CD010683.
23.
Brooks SP, Gelman A. General methods for monitoring convergence of iterative simulations. J Comput Graph Stat. 1998;7:434–55.
24.
Dias S, Welton NJ, Caldwell DM, Ades AE. Checking consistency in mixed treatment comparison meta-analysis. Stat Med. 2010;30:932–44.
25.
26.
Salanti G, Ades AE, Ioannidis JP. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol. 2011;64:163–71.PubMed
27.
Salvo V, Zimmermann LJ, Gavilanes AW, Barberi I, Ricotti A, Abella R, et al. First intention high-frequency oscillatory and conventional mechanical ventilation in premature infants without antenatal glucocorticoid prophylaxis. Pediatr Crit Care Med. 2012;13:72–9.PubMed
28.
Castoldi F, Daniele I, Fontana P, Cavigioli F, Lupo E, Lista G. Lung recruitment maneuver during volume guarantee ventilation of preterm infants with acute respiratory distress syndrome. Am J Perinatol. 2011;28:521–8.PubMed
29.
Carlo WA, Chatburn RL, Martin RJ. Randomized trial of high-frequency jet ventilation versus conventional ventilation in respiratory distress syndrome. J Pediatr. 1987;110:275–82.PubMed
30.
HiFO Study Group. Randomized study of high-frequency oscillatory ventilation in infants with severe respiratory distress syndrome. J Pediatr. 1993;122:609–19.
31.
Pardou A, Vermeylen D, Muller MF, Detemmerman D. High-frequency ventilation and conventional mechanical ventilation in newborn babies with respiratory distress syndrome: a prospective, randomized trial. Intensive Care Med. 1993;19:406–10.PubMed
32.
Wiswell TE, Graziani LJ, Kornhauser MS, Cullen J, Merton DA, McKee L, et al. High-frequency jet ventilation in the early management of respiratory distress syndrome is associated with a greater risk for adverse outcomes. Pediatrics. 1996;98:1035–43.PubMed
33.
Gerstmann DR, Minton SD, Stoddard RA, Meredith KS, Monaco F, Bertrand JM, et al. The Provo multicenter early high-frequency oscillatory ventilation trial: improved pulmonary and clinical outcome in respiratory distress syndrome. Pediatrics. 1996;98:1044–57.PubMed
34.
Beresford MW, Shaw NJ, Manning D. Manning Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed. 2000;82:F14–8.PubMedPubMedCentral
35.
Baumer JH. International randomised controlled trial of patient-triggered ventilation in neonatal respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed. 2000;82:F5–10.PubMedPubMedCentral
36.
Lista G, Colnaghi M, Castoldi F, Condò V, Reali R, Compagnoni G, et al. Impact of targeted-volume ventilation on lung inflammatory response in preterm infants with respiratory pediatric pulmonology distress syndrome (RDS). Pediatr Pulmonol. 2004;37:510–4.PubMed
37.
Nafday SM, Green RS, Lin J, Brion LP, Ochshorn I, Holzman IR. Is there an advantage of using pressure support ventilation with volume guarantee in the initial management of premature infants with respiratory distress syndrome? a pilot study. J Perinatol. 2005;25:193–7.PubMed
38.
Dani C, Bertini G, Pezzati M, Filippi L, Pratesi S, Caviglioli C, et al. Effects of pressure support ventilation plus volume guarantee vs. High-frequency oscillatory ventilation on lung inflammation in preterm infants. Pediatr Pulmonol. 2006;41:242–9.PubMed
39.
Singh J, Sinha SK, Clarke P, Byrne S, Donn SM. Mechanical ventilation of very low birth weight infants: is volume or pressure a better target variable? J Pediatr. 2006;149:308–13.PubMed
40.
Liu CQ, Cui Z, Xia YF, Ma L, Fan LL. Randomized controlled study of targeted tidal volume ventilation for treatment of severe neonatal respiratory distress syndrome. Zhongguo Dang Dai Er Ke Za Zhi. 2011;13:696–9.PubMed
41.
Sun H, Cheng R, Kang W, Xiong H, Zhou C, Zhang Y, et al. High-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation plus pressure support in preterm infants with severe respiratory distress syndrome. Respir Care. 2014;59:159–69.PubMed
42.
Donn SM, Sinha SK. Newer modes of mechanical ventilation for the infant. Curr Opin Pediatr. 2001;13:99–103.PubMed
43.
Sinha SK, Donn SM. Volume-controlled ventilation: variations on a theme. Clin Perinatol. 2001;28:547–60.PubMed
44.
Mrozek JD, Bendel-Stenzel EM, Meyers PA, Bing DR, Connett JE, Mammel MC. Randomized controlled trial of volume targeted synchronized ventilation and conventional intermittent mandatory ventilation following initial exogenous surfactant therapy. Pediatr Pulmonol. 2000;29:11–8.PubMed
45.
Sola A, Saldeno YP, Favareto V. Clinical practices in neonatal oxygenation: where have we failed? What can we do? J Perinatol. 2008;28:S28–34.PubMed
46.
Dhainau J-F, Aouate P, Brunet FP. Circulatory effect of positive end-expiratory pressure in patients with acute lung injury. In: Scharf SM, Cassidy SS, editors. Heart-lung interaction in health and disease. New York: Marcel Dekker; 1989. p. 809–38.
47.
Chaimani A, Vasiliadis HS, Pandis N, Schmid CH, Welton NJ, Salanti G. Effects of study precision and risk of bias in networks of interventions: a network meta-epidemiological study. Int J Epidemiol. 2013;42:1120–31.PubMed
Metadata
Title
Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and network meta-analysis
Authors
Changsong Wang
Libo Guo
Chunjie Chi
Xiaoyang Wang
Lei Guo
Weiwei Wang
Nana Zhao
Yibo Wang
Zhaodi Zhang
Enyou Li
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-0843-7

Other articles of this Issue 1/2015

Critical Care 1/2015 Go to the issue

Research

Efficiency of hydrogen peroxide in improving disinfection of ICU rooms

Research

Targeted screening for third-generation cephalosporin-resistant Enterobacteriaceae carriage among patients admitted to intensive care units: a quasi-experimental study

Research

Pulmonary ultrasound and pulse oximetry versus chest radiography and arterial blood gas analysis for the diagnosis of acute respiratory distress syndrome: a pilot study

Review

Loop diuretics in acute heart failure: beyond the decongestive relief for the kidney

Research

Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness

Commentary

The original sins of clinical trials with intravenous immunoglobulins in sepsis