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Italian Journal of Pediatrics

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Open Access 01-12-2016 | Case report

Kawasaki disease and hepatobiliary involvement: report of two cases

Authors: Ingeborg Marianne Keeling, Elisabeth Beran, Otto Eugen Dapunt

Published in: Italian Journal of Pediatrics | Issue 1/2016

Abstract

Background

Kawasaki disease (KD) without affection of the coronary artery system is rare. Optic nerve pathology together with KD has not been described earlier.

Case presentation

We present one case of KD in a 12-year-old girl predominantly with prolonged cholestasis, and a second case of multiple recurrent KD in a 9-year-old boy with hepatomegaly and ischemic optic nerve neuropathy. The coronary artery system was not involved in either case.

Conclusions

KD warrants rapid diagnosis and immediate specific treatment in order to prevent the high risk of coronary artery aneurysm and stenosis.

Sánchez-Manubens J, Bou R, Anton J. Diagnosis and classification of Kawasaki disease. J Autoimmun. 2014;48–49:113–7.CrossRefPubMed

Zulian F, Falcini F, Zancan L, Martini G, Secchieri S, Luzzatto C, et al. Acute surgical abdomen as presenting manifestation of Kawasaki disease. J Pediatr. 2003;142:731–5.CrossRefPubMed

Majumdar I, Wagner S. Kawasaki disease masquerading as hepatitis: a diagnostic challenge for pediatricians. Clin Pediatr. 2016;55:73–5.CrossRef

Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in The Young, American Heart Association. Pediatr. 2004;114:1708–33. Erratum in: Pediatr 2005;115:1118.CrossRef

Hashkes PJ, Becker ML, Cabral DA, Laxer RM, Paller AS, Rabinovich CE, et al. Methotrexate: new uses for an old drug. J Pediatr. 2014;164:231–6.CrossRefPubMed

Lee WC, Hwang KP, King YT, Chen HC, Chiou SS, Yang RC, et al. Late diagnosis of Kawasaki disease is associated with haptoglobin phenotype. Eur J Clin Invest. 2000;30:379–82.CrossRefPubMed

Eladawy M, Dominguez SR, Anderson MS, Glodé MP. Abnormal liver panel in acute kawasaki disease. Pediatr Infect Dis J. 2011;30:141–4.CrossRefPubMedPubMedCentral

Liu L, Yin W, Wang R, Sun D, He X, Ding Y. The prognostic role of abnormal liver function in IVIG unresponsiveness in Kawasaki disease: a meta-analysis. Inflamm Res 2015 Dec 8 [Epub ahead of print].

Yi DY, Kim JY, Choi EY, Choi JY, Yang HR. Hepatobiliary risk factors for clinical outcome of Kawasaki disease in children. BMC Pediatr. 2014;14:51. doi:10.1186/1471-2431-14-51.CrossRefPubMedPubMedCentral

10.

Yang HM, Du ZD, Fu PP. Clinical features of recurrent Kawasaki disease and its risk factors. Eur J Pediatr. 2013;172:1641–7.CrossRefPubMed

11.

Anand S, Yang YC. Optic disc changes in Kawasaki disease. J Pediatr Ophthalmol Strabismus. 2004;41:177–9.PubMed

12.

Thapa R, Mallick D, Biswas B, Chakrabartty S. Transient unilateral oculomotor palsy and severe headache in childhood Kawasaki disease. Rheumatol Int. 2011;31:97–9.CrossRefPubMed

Title: Kawasaki disease and hepatobiliary involvement: report of two cases
Authors: Ingeborg Marianne Keeling
Elisabeth Beran
Otto Eugen Dapunt
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2016
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-016-0238-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Kawasaki disease and hepatobiliary involvement: report of two cases

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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