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Open Access 01-12-2015 | Review

Risk factors for celiac disease

Authors: Marco Sarno, Valentina Discepolo, Riccardo Troncone, Renata Auricchio

Published in: Italian Journal of Pediatrics | Issue 1/2015

Abstract

Celiac Disease (CD) is an immune-mediated systemic disorder elicited by gluten and related prolamines in genetically susceptible individuals and it is the result of the interaction between genetic and environmental factors. Among genetic risk factors, the strongest association is with the HLA class II DQ region; nevertheless at least 39 non-HLA loci are associated with CD. Gluten is the main environmental trigger of the disease. In addition, infant feeding and weaning practices as well as timing of gluten introduction in the diet have been suggested to contribute to CD risk. Furthermore a role for infectious agents and microbiota composition in disease development has also been proposed.

Aim of this short review is to discuss the current knowledge on both genetic and environmental risk factors for the development of CD; moreover we will provide a brief overview of the possible strategies that could be envisaged to prevent this condition, at least in the population at-risk.

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Title: Risk factors for celiac disease
Authors: Marco Sarno
Valentina Discepolo
Riccardo Troncone
Renata Auricchio
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2015
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-015-0166-y

2024 ASCO Annual Meeting

Springer Medicine

Risk factors for celiac disease

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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