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Open Access 01-12-2021 | Diabetic Foot | Research

Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database

Authors: Masanori Kaneko, Kazuya Fujihara, Mayuko Yamada Harada, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hiroyasu Seida, Satoru Kodama, Hirohito Sone

Published in: Journal of Foot and Ankle Research | Issue 1/2021

Abstract

Background

The prevalence of diabetes is rising, and diabetes develops at a younger age in East Asia. Although lower limb amputation negatively affects quality of life and increases the risk of cardiovascular events, little is known about the rates and predictors of amputation among persons with diabetes from young adults to those in the “young-old” category (50–72 y).

Methods

We analyzed data from a nationwide claims database in Japan accumulated from 2008 to 2016 involving 17,288 people with diabetes aged 18–72 y (mean age 50.2 y, HbA1c 7.2%). Amputation occurrence was determined according to information from the claims database. Cox regression model identified variables related to lower limb amputation.

Results

The mean follow-up time was 5.3 years, during which time 16 amputations occurred (0.17/1000 person-years). Multivariate Cox regression analysis showed that age (hazard ratio [HR] 1.09 [95% confidence intervals] 1.02–1.16, p = 0.01) and HbA1c (HR 1.46 [1.17–1.81], p < 0.01) were independently associated with amputations. Compared with those aged < 60 years with HbA1c < 8.0%, the HR for amputation was 27.81 (6.54–118.23) in those aged ≥60 years and HbA1c ≥8.0%.

Conclusions

Age and HbA1c were associated with amputations among diabetic individuals, and the rates of amputation were significantly greater in those ≥60 years old and with HbA1c ≥8.0%.

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Title: Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database
Authors: Masanori Kaneko
Kazuya Fujihara
Mayuko Yamada Harada
Taeko Osawa
Masahiko Yamamoto
Masaru Kitazawa
Yasuhiro Matsubayashi
Takaho Yamada
Hiroyasu Seida
Satoru Kodama
Hirohito Sone
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Diabetic Foot
Published in: Journal of Foot and Ankle Research / Issue 1/2021
Electronic ISSN: 1757-1146
DOI: https://doi.org/10.1186/s13047-021-00474-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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