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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2017

Open Access 01-12-2017 | Review

hrHPV E5 oncoprotein: immune evasion and related immunotherapies

Authors: Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr., Aldo Venuti

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2017

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Abstract

The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene is responsible for modulation of several immune mechanisms, including antigen presentation and inflammatory pathways. Moreover, E5 was suggested as a promising therapeutic target, since there is still no effective medical therapy for the treatment of HPV-related pre-neoplasia and cancer. Indeed, several studies have shown good prospective for E5 immunotherapy, suggesting that it could be applied for the treatment of pre-cancerous lesions. Thus, insofar as the majority of cervical, oropharyngeal and anal cancers are caused by high-risk HPV (hrHPV), mainly by HPV16, the aim of this review is to discuss the immune pathways interfered by E5 oncoprotein of hrHPV highlighting the various aspects of the potential immunotherapeutic approaches.
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Metadata
Title
hrHPV E5 oncoprotein: immune evasion and related immunotherapies
Authors
Antonio Carlos de Freitas
Talita Helena Araújo de Oliveira
Marconi Rego Barros Jr.
Aldo Venuti
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2017
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-017-0541-1

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