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Open Access 01-12-2014 | Review

Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

Authors: Xun Yuan, Hua Wu, Na Han, Hanxiao Xu, Qian Chu, Shiying Yu, Yuan Chen, Kongming Wu

Published in: Journal of Hematology & Oncology | Issue 1/2014

Abstract

Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate that Notch signaling plays an important role in lung cancer initiation and cross-talks with several transcriptional factors to enhance EMT, contributing to the progression of non-small cell lung cancer (NSCLC). Correspondingly, blocking of Notch signaling inhibits NSCLC migration and tumor growth by reversing EMT. Clinical trials have showed promising effect in some cancer patients received treatment with Notch1 inhibitor. This review attempts to provide an overview of the Notch signal in NSCLC: its biological significance and therapeutic application.

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Title: Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application
Authors: Xun Yuan
Hua Wu
Na Han
Hanxiao Xu
Qian Chu
Shiying Yu
Yuan Chen
Kongming Wu
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2014
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/s13045-014-0087-z

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