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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2014

Open Access 01-12-2014 | Review

Toll-like receptors in the pathogenesis of human B cell malignancies

Authors: Johana M Isaza-Correa, Zheng Liang, Anke van den Berg, Arjan Diepstra, Lydia Visser

Published in: Journal of Hematology & Oncology | Issue 1/2014

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Abstract

Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in this heterogeneous group of cancers. Stimulation with TLR specific ligands, or agonists of their ligands, leads to aberrant responses in the malignant B-cells. According to current data, TLRs can be implicated in malignant transformation, tumor progression and immune evasion processes. Most of the studies focused on multiple myeloma and chronic lymphocytic leukemia, but in the last decade the putative role of TLRs in other types of B-cell lymphomas has gained much interest. The aim of this review is to discuss recent findings on the role of TLRs in normal B cell functioning and their role in the pathogenesis of B-cell malignancies.
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Metadata
Title
Toll-like receptors in the pathogenesis of human B cell malignancies
Authors
Johana M Isaza-Correa
Zheng Liang
Anke van den Berg
Arjan Diepstra
Lydia Visser
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2014
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-014-0057-5

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