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Open Access 01-12-2015 | Short Report

Merkel cell polyomavirus (MCV) T-antigen seroreactivity, MCV DNA in eyebrow hairs, and squamous cell carcinoma

Authors: Shalaka S. Hampras, Angelika Michel, Markus Schmitt, Tim Waterboer, Lena Kranz, Tarik Gheit, Kate Fisher, Vernon K. Sondak, Jane Messina, Neil Fenske, Basil Cherpelis, Massimo Tommasino, Michael Pawlita, Dana E. Rollison

Published in: Infectious Agents and Cancer | Issue 1/2015

Abstract

Background

The role of Merkel cell polyomavirus (MCV) infection in the etiology of non-melanoma skin cancers, other than Merkel cell carcinoma, is unclear. Previously, we reported a significant association between seropositivity to MCV capsid antigen and MCV DNA-positive cutaneous squamous cell carcinoma (SCC). Here we present associations between SCC and seroreactivity to MCV T-antigen (T-Ag) oncoprotein, as well as MCV DNA detected in eyebrow hairs.

Findings

A clinic-based case–control study, including 171 SCC cases and 300 controls without skin cancer, was conducted at Moffitt Cancer Center in Tampa, Florida. Multiplex assays were used to measure serum antibodies against MCV small and large T-Ag and MCV DNA in both eyebrow hairs and SCC tumors (n = 144). Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated using logistic regression to evaluate the associations between MCV and SCC. No significant association was observed between seroreactivity to MCV full-length large or small T-Ag and SCC, overall [OR_{large T-Ag} = 0.99 (0.48-2.08), OR_{small T-Ag} = 0.31 (0.06–1.62)] or when comparing tumor MCV DNA-positive cases to controls [OR_{large T-Ag} = 1.06 (0.38–2.93)]. Only presence of MCV DNA in eyebrow hairs was significantly associated with MCV DNA-positive SCC [OR = 4.05 (2.01–8.18)].

Conclusion

MCV infection is unlikely to play a direct role in SCC.

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Title: Merkel cell polyomavirus (MCV) T-antigen seroreactivity, MCV DNA in eyebrow hairs, and squamous cell carcinoma
Authors: Shalaka S. Hampras
Angelika Michel
Markus Schmitt
Tim Waterboer
Lena Kranz
Tarik Gheit
Kate Fisher
Vernon K. Sondak
Jane Messina
Neil Fenske
Basil Cherpelis
Massimo Tommasino
Michael Pawlita
Dana E. Rollison
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Infectious Agents and Cancer / Issue 1/2015
Electronic ISSN: 1750-9378
DOI: https://doi.org/10.1186/s13027-015-0030-0

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Abstract

Background

Findings

Conclusion

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