Published in:
Open Access
01-12-2019 | Colchicine | Review
Update on the management of colchicine resistant Familial Mediterranean Fever (FMF)
Authors:
Georges El Hasbani, Ali Jawad, Imad Uthman
Published in:
Orphanet Journal of Rare Diseases
|
Issue 1/2019
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Abstract
Background
Familial Mediterranean Fever (FMF), an autoinflammatory disease, is characterized by self-limited inflammatory attacks of fever and polyserositis along with high acute phase response. Although colchicine remains the mainstay in treatment, intolerance and resistance in a certain portion of patients have been posing a problem for physicians.
Main body
Like many autoimmune and autoinflammatory diseases, many colchicine-resistant or intolerant FMF cases have been successfully treated with biologics. In addition, many studies have tested the efficacy of biologics in treating FMF manifestations.
Conclusion
Since carriers of FMF show significantly elevated levels of serum TNF alpha, IL-1, and IL-6, FMF patients who failed colchicine were successfully treated with anti IL-1, anti IL-6, or TNF inhibitors drugs. It is best to use colchicine in combination with biologics.