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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2020 | Research article

Association between breastfeeding and osteoporotic hip fracture in women: a dose-response meta-analysis

Authors: Haixiang Xiao, Quan Zhou, Gouqi Niu, Guansheng Han, Zhongchuan Zhang, Qingbo Zhang, Jianzhong Bai, Xunbing Zhu

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2020

Abstract

Objective

Approximately 300 mg of calcium a day is provided into infants to maintain the physical development of infants, and 5 to 10% bone loss occurs in women during breastfeeding. Hip fractures are considered the most serious type of osteoporotic fracture. We performed this meta-analysis to investigate the association between breastfeeding and osteoporotic hip fractures.

Material and methods

PubMed and Embase were searched until May 1, 2019, for studies evaluating the relationship between breastfeeding and osteoporotic hip fracture in women. The quality of the included studies was evaluated by the methodological index for non-randomized studies (MINORS). For the dose-response meta-analysis, we used the “generalized least squares for trend estimation” method proposed by Greenland and Longnecker to take into account the correlation with the log RR estimates across the duration of breastfeeding.

Results

Seven studies were moderate or high quality, enrolling a total of 103,898 subjects. The pooled outcomes suggested that breastfeeding can decrease the incidence of osteoporotic hip fracture (RR = 0.64 (95% CI 0.43, 0.95), P = 0.027). Dose-response analysis demonstrated that the incidence of osteoporotic hip fracture decreased with the increase of breastfeeding time. The RR and 95% CI for 3 months, 6 months, 12 months, and 24 months were RR = 0.93, 95% CI 0.88, 0.98; RR = 0.87, 95% CI 0.79, 0.96; RR = 0.79, 95% CI 0.67, 0.92; and RR = 0.76, 95% CI 0.59, 0.98, respectively, whereas no significant relationship was found between them when the duration of breastfeeding time was more than 25 months.

Conclusions

Our meta-analysis demonstrated that the incidence of osteoporotic hip fracture decreased with the extension of breastfeeding time. However, there is no significant relationship between them when the duration of breastfeeding time was more than 25 months.

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Title: Association between breastfeeding and osteoporotic hip fracture in women: a dose-response meta-analysis
Authors: Haixiang Xiao
Quan Zhou
Gouqi Niu
Guansheng Han
Zhongchuan Zhang
Qingbo Zhang
Jianzhong Bai
Xunbing Zhu
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2020
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-019-1541-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between breastfeeding and osteoporotic hip fracture in women: a dose-response meta-analysis

Abstract

Objective

Material and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Material and methods

Results

Conclusions

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