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Open Access 01-12-2017 | Research

First intraindividual comparison of contrast-enhanced MRI, FET- and DOTATOC- PET in patients with intracranial meningiomas

Authors: Jan Oliver Dittmar, Clemens Kratochwil, Anne Dittmar, Thomas Welzel, Daniel Habermehl, Stefan Rieken, Frederik L. Giesel, Uwe Haberkorn, Jürgen Debus, Stephanie E. Combs

Published in: Radiation Oncology | Issue 1/2017

Abstract

Background

For irradiation treatment planning of meningiomas the use of PET-scans is well established. The most frequently used tracers are either based on amino acids or the somatostatin receptor ligand DOTATOC. Since up to now no inter-institutionally accepted standard PET-tracer has been defined, the aim of this study was to evaluate the influence of these different types of PET-tracers on the GTV-definition.

Methods

Twenty-one patients suffering from intracranial meningiomas underwent CT, MRI, FET- and DOTATOC-PET. First, tumour extension was delineated after image-fusion of CT and MRI (GTV_CT/MRI). Then distinct GTVs based either on FET- or DOTATOC-PET were contoured and compared with each other as well with GTV_CT/MRI.

Results

Every tumour showed typical enhancement of DOTATOC, but two meningiomas remained FET-negative. The mean relative overlap volume of GTV_FET and GTV_DOTATOC was only 41.9% and there was a significantly stronger correlation between GTV_CT/MRI and GTV_DOTATOC than between GTV_CT/MRI and GTV_FET .

Conclusions

Further investigations are necessary to clarify the minor conformity of DOTATOC- and FET-PET in meningiomas. Because of the receptor targeting, DOTATOC is known to be more specific for meningiomas and will remain the standard in our institution with the known limitation in areas nearby the pituitary gland.

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Title: First intraindividual comparison of contrast-enhanced MRI, FET- and DOTATOC- PET in patients with intracranial meningiomas
Authors: Jan Oliver Dittmar
Clemens Kratochwil
Anne Dittmar
Thomas Welzel
Daniel Habermehl
Stefan Rieken
Frederik L. Giesel
Uwe Haberkorn
Jürgen Debus
Stephanie E. Combs
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2017
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/s13014-017-0913-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

First intraindividual comparison of contrast-enhanced MRI, FET- and DOTATOC- PET in patients with intracranial meningiomas

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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