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Diagnostic Pathology

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Open Access 01-12-2022 | Fluorescence in Situ Hybridization | Case Report

Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy

Authors: Yanling Zhang, Wen Han, Jun Zhou, Xiang Yong

Published in: Diagnostic Pathology | Issue 1/2022

Abstract

Introduction

Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors. They most commonly involve the minor salivary glands of the head and neck. HCCC that occurs in uncommon locations and examining samples from small biopsy pose a diagnostic challenge for most pathologists.

Case presentation

We herein report a primary pulmonary HCCC diagnosed by small biopsy and summarize its histologic, immunophenotypic, and molecular features along with a review of 11 previously reported cases to emphasize the potential diagnostic pitfalls.

Conclusions

Small biopsy diagnosis of primary pulmonary HCCC is challenging. A collection of mimics needed to be ruled out. Awareness of the key morphologic features of pulmonary HCCC combined with essential immunohistochemistry and molecular tests contributes to the correct diagnosis.

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Title: Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy
Authors: Yanling Zhang
Wen Han
Jun Zhou
Xiang Yong
Publication date: 01-12-2022
Publisher: BioMed Central
Keyword: Fluorescence in Situ Hybridization
Published in: Diagnostic Pathology / Issue 1/2022
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-022-01216-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Primary lung hyalinizing clear cell carcinoma: a diagnostic challenge in biopsy

Abstract

Introduction

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Case presentation

Conclusions

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