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Open Access 01-12-2016 | Case Report

Massive ovarian oedema: a misleading clinical entity

Authors: Nikolaos Machairiotis, Aikaterini Stylianaki, Paraskevi Kouroutou, Polixeni Sarli, Nikolaos Konstantinos Alexiou, Elias Efthymiou, Athanasios Maras, Nikolaos Georgios Alexiou, Spyridon Evaggelos Nikolaou, Nikolaos Courcoutsakis, Eleni Papakonstantinou, Paul Zarogoulidis, Nikolaos Barbetakis, Dimitrios Paliouras, Apostolos Gogakos, Christodoulos Machairiotis

Published in: Diagnostic Pathology | Issue 1/2016

Abstract

Background

Massive ovarian oedema is a rare non-neoplastic clinicopathologic entity has a higher incidence in women during their second and third life decade. The oedema can be presented in one or both ovaries as a result of partial intermittent torsion of the ovarian pedicle that interferes to the venal and lymphatic drainage of the ovary.

Case presentation

We present a clinical case of a 16 year old with massive ovarian oedema and we performed a review of the literature. The pathophysiology of this entity is very complex. We tried to perform a complete review of the literature and focus on the complexity of this entity as far as its pathophysiological backround is concerned and as far as its clinical presentation is concerned.

Conclusions

In conclusion, massive ovarian oedema is a rare, multi disease mimicking clinical entity, with an acute or progressive clinical presentation. It has also to be a part of our differential diagnosis in cases of acute abdominal pain and we have to try to treat her conservatively, in order to preserve fertility.

Kalstone CE, Jaffe RB, Abell MR. Massive edema of the ovary simulating fibroma. Obstet Gynecol. 1969;34(4):564–71.PubMed

Roth LM, Deaton RL, Sternberg WH. Massive ovarian edema. A clinicopathologic study of five cases including ultrastructural observations and review of the literature. Am J Surg Pathol. 1979;3(1):11–21.CrossRefPubMed

Nogales FF, Martin-Sances L, Mendoza-Garcia E, Salamanca A, Gonzalez-Nunez MA, Pardo Mindan FJ. Massive ovarian oedema. Histopathology. 1996;28(3):229–34.CrossRefPubMed

Eden JA. Massive ovarian oedema. Br J Obstet Gynaecol. 1994;101(5):456–8.CrossRefPubMed

Roth LM. Massive ovarian edema with stromal luteinization: a newly recognized virilizing syndrome apparently related to partial torsion of the mesovarium. Am J Clin Pathol. 1971;55(6):757–60.PubMed

Daboubi MK, Khreisat B. Massive ovarian oedema: literature review and case presentation. East Mediterr Health J. 2008;14(4):972–7.PubMed

Taylor PD, Wilson H, Hillier SG, Wiegand SJ, Fraser HM. Effects of inhibition of vascular endothelial growth factor at time of selection on follicular angiogenesis, expansion, development and atresia in the marmoset. Mol Hum Reprod. 2007;13(10):729–36. doi:10.1093/molehr/gam056.CrossRefPubMed

Ferrara N, Chen H, Davis-Smyth T, Gerber HP, Nguyen TN, Peers D, et al. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat Med. 1998;4(3):336–40.CrossRefPubMed

Zimmermann RC, Hartman T, Kavic S, Pauli SA, Bohlen P, Sauer MV, et al. Vascular endothelial growth factor receptor 2-mediated angiogenesis is essential for gonadotropin-dependent follicle development. J Clin Invest. 2003;112(5):659–69. doi:10.1172/JCI18740.PubMedCentralCrossRefPubMed

10.

Findlay JK, Tsonis CG, Staples LD, Cahill RN. Inhibin secretion by the sheep ovary. J Reprod Fertil. 1986;76(2):751–61.CrossRefPubMed

11.

Stefanczyk-Krzymowska S, Krzymowski T, Wasowska B, Chlopek J. Retrograde transfer of ovarian steroid hormones to the ovary in the porcine periovarian vascular complex. Exp Physiol. 2002;87(3):361–71.CrossRefPubMed

12.

Brown HM, Russell DL. Blood and lymphatic vasculature in the ovary: development, function and disease. Hum Reprod Update. 2014;20(1):29–39. doi:10.1093/humupd/dmt049.CrossRefPubMed

13.

Kawaguchi R, Ueda S, Tsuji Y, Haruta S, Kanayama S, Yamada Y, et al. Massive ovarian edema in pregnancy after ovulation induction using clomiphene citrate. Arch Gynecol Obstet. 2008;277(4):375–8. doi:10.1007/s00404-007-0474-6.CrossRefPubMed

14.

Chervenak FA, Castadot MJ, Wiederman J, Sedlis A. Massive ovarian edema: review of world literature and report of two cases. Obstet Gynecol Surv. 1980;35(11):677–84.CrossRefPubMed

15.

Vasquez SB, Sotos JF, Kim MH. Massive edema of the ovary and virilization. Obstet Gynecol. 1982;59(6 Suppl):95S–9S.PubMed

16.

Krasevic M, Haller H, Rupcic S, Behrem S. Massive edema of the ovary: a report of two cases due to lymphatic permeation by metastatic carcinoma from the uterine cervix. Gynecol Oncol. 2004;93(2):564–7. doi:10.1016/j.ygyno.2004.02.015.CrossRefPubMed

17.

Dalloul M, Sherer DM, Gorelick C, Serur E, Zinn H, Sanmugarajah J, et al. Transient bilateral ovarian enlargement associated with large retroperitoneal lymphoma. Ultrasound Obstet Gynecol. 2007;29(2):236–8. doi:10.1002/uog.3920.CrossRefPubMed

18.

Kanumakala S, Warne GL, Stokes KB, Chan YF, Grover S. Massive ovarian edema causing early puberty. J Pediatr Endocrinol Metab. 2002;15(6):861–4.CrossRefPubMed

19.

Mutijima E, Mokni M, Soua Ael H, Ziadi S, Mestiri S, Yacoubi MT, et al. Massive ovarian oedema. Rev Med Liege. 2004;59(9):522–4.PubMed

20.

Elkins TE, Stock RJ. Recurrent massive edema of the ovary. South Med J. 1982;75(4):478–80.CrossRefPubMed

21.

Praveen R, Pallavi V, Rajashekar K, Usha A, Umadevi K, Bafna U. A clinical update on massive ovarian oedema - a pseudotumour? Ecancermedicalscience. 2013;7:318. doi:10.3332/ecancer.2013.318.PubMedCentralPubMed

22.

Kocak M, Caliskan E, Haberal A. Laparoscopic conservation of the ovaries in cases with massive ovarian oedema. Gynecol Obstet Invest. 2002;53(2):129–32. doi:53009.CrossRefPubMed

23.

Kallipolitis G, Sklia E, Milingos S, Michalas S. Laparoscopic treatment of massive ovarian edema. J Am Assoc Gynecol Laparosc. 1999;6(4):513–6.CrossRefPubMed

Title: Massive ovarian oedema: a misleading clinical entity
Authors: Nikolaos Machairiotis
Aikaterini Stylianaki
Paraskevi Kouroutou
Polixeni Sarli
Nikolaos Konstantinos Alexiou
Elias Efthymiou
Athanasios Maras
Nikolaos Georgios Alexiou
Spyridon Evaggelos Nikolaou
Nikolaos Courcoutsakis
Eleni Papakonstantinou
Paul Zarogoulidis
Nikolaos Barbetakis
Dimitrios Paliouras
Apostolos Gogakos
Christodoulos Machairiotis
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2016
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-016-0469-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Massive ovarian oedema: a misleading clinical entity

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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