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Diagnostic Pathology

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Open Access 01-12-2015 | Case Report

Crystalloid podocytopathy with focal segmental glomerulosclerosis in PCM: a case report

Authors: You La Jeon, Woo In Lee, Yujin Choi, So Young Kang, Myeong Hee Kim, Sung-Jig Lim, Sang Ho Lee

Published in: Diagnostic Pathology | Issue 1/2015

Abstract

Background

Crystalloid podocytopathy with focal segmental glomerulosclerosis in plasma cell myeloma (PCM) is rare.

Case Presentation

We present a case of crystalline deposition in the bone marrow (BM) and various renal cells with only proteinuria as a symptom. As workup for proteinuria, a renal biopsy sample was obtained. EM showed multiple crystalline depositions in renal tubular cells and podocytes. Focal segmental glomerulosclerosis with crystalloid podocytopathy was diagnosed. Because monoclonal gammopathy was detected in the serum and urine, a BM study was also performed. Plasma cells with needle-shaped inclusion bodies were observed. The crystalline deposits in the plasma cells and podocytes were positive for Masson’s trichrome and kappa light-chain staining. These findings indicated that the crystalline deposits originated from paraprotein. The case showed a rare process of focal segmental glomerulosclerosis via crystalline deposition in podocytes in plasma cell myeloma.

Conclusions

Crystalloid podocytopathy is a likely cause of renal damage such as FSGS in PCM, although it is an uncommon mechanism for myeloma kidney.

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Title: Crystalloid podocytopathy with focal segmental glomerulosclerosis in PCM: a case report
Authors: You La Jeon
Woo In Lee
Yujin Choi
So Young Kang
Myeong Hee Kim
Sung-Jig Lim
Sang Ho Lee
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2015
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-015-0448-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Crystalloid podocytopathy with focal segmental glomerulosclerosis in PCM: a case report

Abstract

Background

Case Presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case Presentation

Conclusions

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