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Open Access 01-12-2023 | Obsessive-Compulsive Disorder | Research

Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats

Authors: Elena Martín-González, Ángeles Prados-Pardo, Stephen J. Sawiak, Jeffrey W. Dalley, Daniel Padro, Pedro Ramos-Cabrer, Santiago Mora, Margarita Moreno-Montoya

Published in: Behavioral and Brain Functions | Issue 1/2023

Abstract

Compulsivity is considered a transdiagnostic dimension in obsessive–compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical circuitry. The present study investigated the structural morphology of white and gray matter in rats selected for low- (LD) and high- (HD) compulsive drinking behavior on a schedule-induced polydipsia (SIP) task. Regional brain morphology was assessed using ex-vivo high-resolution magnetic resonance imaging (MRI). Voxel-based morphometry of segmented MRI images revealed larger white matter volumes in anterior commissure and corpus callosum of HD rats compared with LD rats. HD rats also showed significantly larger regional volumes of dorsolateral orbitofrontal cortex, striatum, amygdala, hippocampus, midbrain, sub-thalamic nucleus, and cerebellum. By contrast, the medial prefrontal cortex was significantly smaller in HD rats compared with LD rats with no significant group differences in whole brain, ventricular, or cerebrospinal fluid volumes. These findings show that limbic cortico-basal ganglia structures implicated in impulse control disorders are distinct in rats that are vulnerable to develop compulsive behavior. Such abnormalities may be relevant to the etiology of compulsive disorders in humans.

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Title: Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats
Authors: Elena Martín-González
Ángeles Prados-Pardo
Stephen J. Sawiak
Jeffrey W. Dalley
Daniel Padro
Pedro Ramos-Cabrer
Santiago Mora
Margarita Moreno-Montoya
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Obsessive-Compulsive Disorder
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Behavioral and Brain Functions / Issue 1/2023
Electronic ISSN: 1744-9081
DOI: https://doi.org/10.1186/s12993-023-00221-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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