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Behavioral and Brain Functions

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Open Access 01-12-2016 | Research

Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression

Authors: Shinya Kinoshita, Tetsufumi Kanazawa, Hiroki Kikuyama, Hiroshi Yoneda

Published in: Behavioral and Brain Functions | Issue 1/2015

Abstract

Background

To reduce the number of patients with depression, biomarkers for clarifying psychiatric disorders are warranted. Numerous candidates have been proposed; however, near-infrared spectroscopy (NIRS) with multi-channel probes and a dexamethasone/corticotropin-releasing hormone (DEX/CRH) test are still surviving for practical demand. Thirty-one outpatients with depressed moods were analyzed using both biological tests.

Results

The non-suppressors, as indicated by the DEX/CRH test, exhibited a high severity on the Hamilton Depression Scale and severe anxiety on the State Trait Anxiety Scale. In addition, a unique response was identified via NIRS in the same group suggested by the DEX/CRH assessment.

Conclusions

The results obtained from these biological tests did not fit well with the category defined by operative diagnostic criteria, such as the Diagnostic and Statistical Manual of Mental Disorders or The International Classification of Diseases. Thus, it is critical that the utility evaluations of candidate biomarkers not be assessed by comparisons with the categorized criteria for a specific psychiatric disorder.

Trial registration UMIN000013214, Registered 21 February 2014

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Title: Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression
Authors: Shinya Kinoshita
Tetsufumi Kanazawa
Hiroki Kikuyama
Hiroshi Yoneda
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Behavioral and Brain Functions / Issue 1/2015
Electronic ISSN: 1744-9081
DOI: https://doi.org/10.1186/s12993-016-0108-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression

Abstract

Background

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Results

Conclusions

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