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Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2015

Open Access 01-12-2016 | Review

BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis

Authors: Galina Y. Zheleznyakova, Hao Cao, Helgi B. Schiöth

Published in: Behavioral and Brain Functions | Issue 1/2015

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Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.
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Metadata
Title
BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
Authors
Galina Y. Zheleznyakova
Hao Cao
Helgi B. Schiöth
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2015
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/s12993-016-0101-4

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