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Emerging Themes in Epidemiology
Published in: Emerging Themes in Epidemiology 1/2016

Open Access 01-12-2016 | Review

The obese gut microbiome across the epidemiologic transition

Authors: Lara R. Dugas, Miles Fuller, Jack Gilbert, Brian T. Layden

Published in: Emerging Themes in Epidemiology | Issue 1/2016

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Abstract

The obesity epidemic has emerged over the past few decades and is thought to be a result of both genetic and environmental factors. A newly identified factor, the gut microbiota, which is a bacterial ecosystem residing within the gastrointestinal tract of humans, has now been implicated in the obesity epidemic. Importantly, this bacterial community is impacted by external environmental factors through a variety of undefined mechanisms. We focus this review on how the external environment may impact the gut microbiota by considering, the host’s geographic location ‘human geography’, and behavioral factors (diet and physical activity). Moreover, we explore the relationship between the gut microbiota and obesity with these external factors. And finally, we highlight here how an epidemiologic model can be utilized to elucidate causal relationships between the gut microbiota and external environment independently and collectively, and how this will help further define this important new factor in the obesity epidemic.
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Metadata
Title
The obese gut microbiome across the epidemiologic transition
Authors
Lara R. Dugas
Miles Fuller
Jack Gilbert
Brian T. Layden
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Emerging Themes in Epidemiology / Issue 1/2016
Electronic ISSN: 1742-7622
DOI
https://doi.org/10.1186/s12982-015-0044-5

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