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Immunity & Ageing
Published in: Immunity & Ageing 1/2015

Open Access 01-12-2015 | Research

End stage renal disease patients have a skewed T cell receptor Vβ repertoire

Authors: Ling Huang, Anton W. Langerak, Ingrid L. M. Wolvers-Tettero, Ruud W. J. Meijers, Carla C. Baan, Nicolle H. R. Litjens, Michiel G. H. Betjes

Published in: Immunity & Ageing | Issue 1/2015

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Abstract

Background

End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) Vβ repertoire is central to effective T-cell mediated immune responses to foreign antigens. In this study, the effect of ESRD on TCR Vβ repertoire was assessed.

Results

A higher proportion of ESRD patients (68.9 %) had a skewed TCR Vβ repertoire compared to age and cytomegalovirus (CMV) – IgG serostatus matched healthy individuals (31.4 %, P < 0.001). Age, CMV serostatus and ESRD were independently associated with an increase in shifting of the TCR Vβ repertoire. More differentiated CD8+ T cells were observed in young ESRD patients with a shifted TCR Vβ repertoire. CD31-expressing naive T cells and relative telomere length of T cells were not significantly related to TCR Vβ skewing.

Conclusions

ESRD significantly skewed the TCR Vβ repertoire particularly in the elderly population, which may contribute to the uremia-associated defect in T-cell mediated immunity.
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Metadata
Title
End stage renal disease patients have a skewed T cell receptor Vβ repertoire
Authors
Ling Huang
Anton W. Langerak
Ingrid L. M. Wolvers-Tettero
Ruud W. J. Meijers
Carla C. Baan
Nicolle H. R. Litjens
Michiel G. H. Betjes
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Immunity & Ageing / Issue 1/2015
Electronic ISSN: 1742-4933
DOI
https://doi.org/10.1186/s12979-015-0055-7

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