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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2022

Open Access 01-12-2022 | Fertility | Review

Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive review

Authors: Gabriela Beroukhim, Ecem Esencan, David B. Seifer

Published in: Reproductive Biology and Endocrinology | Issue 1/2022

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Abstract

Sleep is vital to human bodily function. Growing evidence indicates that sleep deprivation, disruption, dysrhythmia, and disorders are associated with impaired reproductive function and poor clinical outcomes in women. These associations are largely mediated by molecular-genetic and hormonal pathways, which are crucial for the complex and time sensitive processes of hormone synthesis/secretion, folliculogenesis, ovulation, fertilization, implantation, and menstruation. Pathologic sleep patterns are closely linked to menstrual irregularity, polycystic ovarian syndrome, premature ovarian insufficiency, sub/infertility, and early pregnancy loss. Measures of success with assisted reproductive technology are also lower among women who engage in shift work, or experience sleep disruption or short sleep duration. Extremes of sleep duration, poor sleep quality, sleep disordered breathing, and shift work are also associated with several harmful conditions in pregnancy, including gestational diabetes and hypertensive disorders. While accumulating evidence implicates pathologic sleep patterns in impaired reproductive function and poor reproductive outcomes, additional research is needed to determine causality and propose therapeutic interventions.
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Metadata
Title
Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive review
Authors
Gabriela Beroukhim
Ecem Esencan
David B. Seifer
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2022
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-022-00889-3

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