Published in:
Open Access
01-12-2019 | Review
Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
Authors:
Yubin Cao, Zeping Li, Wenyu Jiang, Yan Ling, Haibin Kuang
Published in:
Reproductive Biology and Endocrinology
|
Issue 1/2019
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Abstract
Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.