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Open Access 01-12-2016 | Review

Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay

Authors: Savino Sciascia, Simone Baldovino, Karen Schreiber, Laura Solfietti, Massimo Radin, Maria J. Cuadrado, Elisa Menegatti, Doruk Erkan, Dario Roccatello

Published in: Clinical and Molecular Allergy | Issue 1/2016

Abstract

Antiphospholipid syndrome (APS) is an autoimmune condition characterized by the presence of antiphospholipid antibodies (aPL) in subjects presenting with thrombosis and/or pregnancy loss. The currently used classification criteria were updated in the international consensus held in Sidney in 2005. Vascular events seem to result of local procoagulative alterations upon triggers influence (the so called “second-hit theory”), while placental thrombosis and complement activation seem to lead to pregnancy morbidity. The laboratory tests suggested by the current classification criteria include lupus anticoagulant, a functional coagulation assay, and anticardiolipin and anti-β2-glycoprotein-I antibodies, generally detected by solid phase enzyme-linked immunosorbent assay. The real challenge for treating physicians is understanding what is the actual weight of aPL in provoking clinical manifestations in each case. As thrombosis has a multi-factorial cause, each patient needs a risk-stratified approach. In this review we discuss the role of thrombotic risk assessment in primary and secondary prevention of venous and arterial thromboembolic disease in patients with APS, focusing on new antibody specificities, available risk scoring models and new coagulation assays.

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Title: Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay
Authors: Savino Sciascia
Simone Baldovino
Karen Schreiber
Laura Solfietti
Massimo Radin
Maria J. Cuadrado
Elisa Menegatti
Doruk Erkan
Dario Roccatello
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Clinical and Molecular Allergy / Issue 1/2016
Electronic ISSN: 1476-7961
DOI: https://doi.org/10.1186/s12948-016-0043-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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