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Molecular Cancer
Published in: Molecular Cancer 1/2019

Open Access 01-12-2019 | Suicide | Review

Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity

Authors: Shengnan Yu, Ming Yi, Shuang Qin, Kongming Wu

Published in: Molecular Cancer | Issue 1/2019

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Abstract

Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma. However, the application of CAR-T cells is obviously hampered by the adverse effects, such as cytokines release syndrome and on-target off-tumor toxicity. In some clinical trials, patients quitted the treatment of CAR-T cells due to life-threatening toxicity. Seeking to alleviate these toxicities or prevent the occurrence, researchers have developed a number of safety strategies of CAR-T cells, including suicide genes, synthetic Notch receptor, on-switch CAR, combinatorial target-antigen recognition, bispecific T cell engager and inhibitory CAR. This review summarized the preclinical studies and clinical trials of the safety strategies of CAR-T cells and their respective strengths and weaknesses.
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Metadata
Title
Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity
Authors
Shengnan Yu
Ming Yi
Shuang Qin
Kongming Wu
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2019
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-019-1057-4

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