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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2015

Open Access 01-12-2015 | Original investigation

PROMETHEUS: an observational, cross-sectional, retrospective study of hypertriglyceridemia in Russia

Authors: Yuri Karpov, Yunona Khomitskaya

Published in: Cardiovascular Diabetology | Issue 1/2015

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Abstract

Background

Data regarding the prevalence of hypertriglyceridemia in the Russian population are lacking, despite triglyceride (TG)-mediated pathways being causal in cardiovascular disease. The prevalence of mixed dyslipidemia and severe hypertriglyceridemia in the Russian population (PROMETHEUS) was undertaken to address this gap.

Methods

This was an observational, cross-sectional retrospective study. Data from adults with a full/partial lipoprotein record who had blood analyses done at an INVITRO laboratory in Russia between January 1, 2011 and December 31, 2013 were analyzed. The primary endpoint was the prevalence of hypertriglyceridemia (TG ≥ 1.7 mmol/L); secondary endpoints included prevalence of borderline high, high, and very high TG and severe hypertriglyceridemia, defined as a TG level of 1.7 to <2.3, 2.3 to <5.6, ≥5.6, and ≥10.0 mmol/L, respectively. Statistical analyses involved the Wilcoxon and the Chi square tests. Correlations between log-transformed TG and low- and high-density lipoprotein cholesterol (LDL-C and HDL-C) and total cholesterol (TC) were assessed. The correlation between glycated hemoglobin (HbA1c) and TG levels in a nested sample of subjects with HbA1c and TG data was also assessed using a log-linear model.

Results

The full dataset and nested sample comprised 357,072 and 54,602 individuals, respectively. Prevalence of hypertriglyceridemia, borderline high TG, high TG, very high TG, and severe hypertriglyceridemia in the full dataset was 29.2, 16.2, 12.9, 0.11, and 0.011 %, respectively; corresponding rates in the nested sample were 19.0, 17.2, 0.25, and 0.016 %, respectively. TG levels were 16.4 % higher in males versus females; males had a greater risk of hypertriglyceridemia (risk ratio 1.25; 95 % CI 1.24, 1.26; P < 0.0001). Prevalence of hypertriglyceridemia increased with age, peaking at 40–49 years in males (42.8 %) and 60–69 years in females (34.4 %); a 0.61 % increase in TG levels for each year of life was predicted. Hypertriglyceridemia prevalence increased over time. Correlations between TG and LDL-C, HDL-C, TC, and HbA1c (nested sample only) were observed.

Conclusions

Almost one-third of Russians have hypertriglyceridemia, but severe disease (TG ≥ 10.0 mmol/L) is rare. Although the risk of hypertriglyceridemia was greater in males versus females, its prevalence increased with age, regardless of sex. TG was associated with HbA1c, LDL-C, HDL-C, and TC.
Literature
1.
Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, Ginsberg HN et al (2011) Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 123:2292–2333PubMedCrossRef
2.
Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E et al (2010) Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 375:1634–1639CrossRefPubMedCentral
3.
Tenenbaum A, Klempfner R, Fisman EZ (2014) Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor. Cardiovasc Diabetol 13:159PubMedCrossRefPubMedCentral
4.
Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM (2007) Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 298:309–316PubMedCrossRef
5.
Freiberg JJ, Tybjaerg-Hansen A, Jensen JS, Nordestgaard BG (2008) Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA 300:2142–2152PubMedCrossRef
6.
Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A (2007) Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 298:299–308PubMedCrossRef
7.
8.
9.
10.
11.
Expert Panel on Detection E, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 285:2486–2497CrossRef
12.
Ewald N, Hardt PD, Kloer HU (2009) Severe hypertriglyceridemia and pancreatitis: presentation and management. Curr Opin Lipidol 20:497–504PubMedCrossRef
13.
Beltran-Sanchez H, Harhay MO, Harhay MM, McElligott S (2013) Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999–2010. J Am Coll Cardiol 62:697–703PubMedCrossRefPubMedCentral
14.
Costa J, Borges M, Oliveira E, Gouveia M, Carneiro AV (2003) Incidence and prevalence of hypercholesterolemia in Portugal: a systematic review. Part III Rev Port Cardiol 22:829–836PubMed
15.
Ford ES, Li C, Zhao G, Pearson WS, Mokdad AH (2009) Hypertriglyceridemia and its pharmacologic treatment among US adults. Arch Intern Med 169:572–578PubMedCrossRef
16.
Garcez MR, Pereira JL, Fontanelli MM, Marchioni DM, Fisberg RM (2014) Prevalence of dyslipidemia according to the nutritional status in a representative sample of Sao Paulo. Arq Bras Cardiol 103:476–484PubMedPubMedCentral
17.
Gupta A, Gupta R, Sharma KK, Lodha S, Achari V, Asirvatham AJ et al (2014) Prevalence of diabetes and cardiovascular risk factors in middle-class urban participants in India. BMJ Open Diabetes Res Care 2:e000048PubMedCrossRefPubMedCentral
18.
Qiao Q, Group DS (2006) Comparison of different definitions of the metabolic syndrome in relation to cardiovascular mortality in European men and women. Diabetologia 49:2837–2846CrossRef
19.
Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Keil U (2009) EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries. Eur J Cardiovasc Prev Rehabil 16:121–137PubMedCrossRef
20.
Sidorenkov O, Nilssen O, Brenn T, Martiushov S, Arkhipovsky VL, Grjibovski AM (2010) Prevalence of the metabolic syndrome and its components in Northwest Russia: the Arkhangelsk study. BMC Public Health 10:23PubMedCrossRefPubMedCentral
21.
Konradi AO, Rotar OP, Korostovtseva LS, Ivanenko VV, Solntcev VN, Anokhin SB et al (2011) Prevalence of metabolic syndrome components in a population of bank employees from St. Petersburg, Russia. Metab Syndr Relat Disord 9:337–343PubMedCrossRef
22.
Metelskaya VA, Shkolnikova MA, Shalnova SA, Andreev EM, Deev AD, Jdanov DA et al (2012) Prevalence, components, and correlates of metabolic syndrome (MetS) among elderly Muscovites. Arch Gerontol Geriatr 55:231–237PubMedCrossRefPubMedCentral
23.
Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502PubMed
24.
Hegele RA, Ginsberg HN, Chapman MJ, Nordestgaard BG, Kuivenhoven JA, Averna M et al (2014) The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol 2:655–666PubMedCrossRefPubMedCentral
25.
26.
Gavrila D, Salmeron D, Egea-Caparros JM, Huerta JM, Perez-Martinez A, Navarro C et al (2011) Prevalence of metabolic syndrome in Murcia Region, a southern European Mediterranean area with low cardiovascular risk and high obesity. BMC Public Health 11:562PubMedCrossRefPubMedCentral
27.
Hildrum B, Mykletun A, Hole T, Midthjell K, Dahl AA (2007) Age-specific prevalence of the metabolic syndrome defined by the International Diabetes Federation and the National Cholesterol Education Program: the Norwegian HUNT 2 study. BMC Public Health 7:220PubMedCrossRefPubMedCentral
28.
Miccoli R, Bianchi C, Odoguardi L, Penno G, Caricato F, Giovannitti MG et al (2005) Prevalence of the metabolic syndrome among Italian adults according to ATP III definition. Nutr Metab Cardiovasc Dis 15:250–254PubMedCrossRef
29.
Lyudinina AY, Eseva TV, Potolitsyna NN, Chernykh AA, Bojko ER (2014) Fatty acids composition and food consumption among reindeer herders and urban inhabitants of the European North of Russia. Rural Remote Health 14:2539PubMed
30.
Carroll MD, Lacher DA, Sorlie PD, Cleeman JI, Gordon DJ, Wolz M et al (2005) Trends in serum lipids and lipoproteins of adults, 1960–2002. JAMA 294:1773–1781PubMedCrossRef
31.
Poehlman ET, Toth MJ, Ades PA, Rosen CJ (1997) Menopause-associated changes in plasma lipids, insulin-like growth factor I and blood pressure: a longitudinal study. Eur J Clin Invest 27:322–326PubMedCrossRef
32.
Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ et al (2014) Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation 129:e28–e292PubMedCrossRef
33.
Gosswald A, Schienkiewitz A, Nowossadeck E, Busch MA (2013) Prevalence of myocardial infarction and coronary heart disease in adults aged 40–79 years in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:650–655PubMedCrossRef
34.
35.
36.
Bessembinders K, Wielders J, van de Wiel A (2011) Severe hypertriglyceridemia influenced by alcohol (SHIBA). Alcohol Alcohol 46:113–116PubMedCrossRef
37.
Pownall HJ, Ballantyne CM, Kimball KT, Simpson SL, Yeshurun D, Gotto AM Jr (1999) Effect of moderate alcohol consumption on hypertriglyceridemia: a study in the fasting state. Arch Intern Med 159:981–987PubMedCrossRef
38.
39.
Shimomura T, Wakabayashi I (2013) Inverse associations between light-to-moderate alcohol intake and lipid-related indices in patients with diabetes. Cardiovasc Diabetol 12:104PubMedCrossRefPubMedCentral
40.
Carroll MD, Kit BK, Lacher DA, Shero ST, Mussolino ME (2012) Trends in lipids and lipoproteins in US adults, 1988–2010. JAMA 308:1545–1554PubMedCrossRef
41.
Ford ES, Li C, Sniderman A (2013) Temporal changes in concentrations of lipids and apolipoprotein B among adults with diagnosed and undiagnosed diabetes, prediabetes, and normoglycemia: findings from the National Health and Nutrition Examination Survey 1988–1991 to 2005–2008. Cardiovasc Diabetol 12:26PubMedCrossRefPubMedCentral
42.
Vollenweider P, von Eckardstein A, Widmann C (2015) HDLs, diabetes, and metabolic syndrome. Handb Exp Pharmacol 224:405–421PubMedCrossRef
43.
44.
Catapano AL, Reiner Z, De Backer G, Graham I, Taskinen MR, Wiklund O et al (2011) ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis 217(Suppl 1):S1–S44PubMed
45.
Fruchart JC, Davignon J, Hermans MP, Al-Rubeaan K, Amarenco P, Assmann G et al (2014) Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol 13:26PubMedCrossRefPubMedCentral
46.
Davignon J (1998) Advances in drug treatment of dyslipidemia: focus on atorvastatin. Can J Cardiol 14(Suppl B):28B–38BPubMed
47.
Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D et al (2001) Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA 285:1711–1718PubMedCrossRef
48.
Miselli MA, Nora ED, Passaro A, Tomasi F, Zuliani G (2014) Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: a longitudinal observational study. Cardiovasc Diabetol 13:135PubMedCrossRefPubMedCentral
49.
Schwartz GG, Abt M, Bao W, DeMicco D, Kallend D, Miller M et al (2015) Fasting triglycerides predict recurrent ischemic events in patients with acute coronary syndrome treated with statins. J Am Coll Cardiol 65:2267–2275PubMedCrossRef
50.
Ohno Y, Miyoshi T, Noda Y, Oe H, Toh N, Nakamura K et al (2014) Bezafibrate improves postprandial hypertriglyceridemia and associated endothelial dysfunction in patients with metabolic syndrome: a randomized crossover study. Cardiovasc Diabetol 13:71PubMedCrossRefPubMedCentral
51.
Bays HE, Ballantyne CM, Kastelein JJ, Isaacsohn JL, Braeckman RA, Soni PN (2011) Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial). Am J Cardiol 108:682–690PubMedCrossRef
52.
Harris WS, Ginsberg HN, Arunakul N, Shachter NS, Windsor SL, Adams M et al (1997) Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk 4:385–391PubMedCrossRef
53.
Kastelein JJ, Maki KC, Susekov A, Ezhov M, Nordestgaard BG, Machielse BN et al (2014) Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial. J Clin Lipidol 8:94–106PubMedCrossRef
54.
National Institutes of Health (2015) A study of AMR101 to evaluate its ability to reduce cardiovascular events in high risk patients with hypertriglyceridemia and on statin. The primary objective is to evaluate the effect of 4 g/day AMR101 for preventing the occurrence of a first major cardiovascular event (REDUCE-IT). http://​clinicaltrials.​gov/​show/​NCT01492361. Accessed 24 July 2015
55.
56.
Christian JB, Bourgeois N, Snipes R, Lowe KA (2011) Prevalence of severe (500–2,000 mg/dl) hypertriglyceridemia in United States adults. Am J Cardiol 107:891–897PubMedCrossRef
57.
Berglund L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, Murad MH et al (2012) Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 97:2969–2989PubMedCrossRefPubMedCentral
58.
Neil HA, Cooper J, Betteridge DJ, Capps N, McDowell IF, Durrington PN et al (2010) All-cause and cardiovascular mortality in treated patients with severe hypertriglyceridaemia: a long-term prospective registry study. Atherosclerosis 211:618–623PubMedCrossRef
Metadata
Title
PROMETHEUS: an observational, cross-sectional, retrospective study of hypertriglyceridemia in Russia
Authors
Yuri Karpov
Yunona Khomitskaya
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2015
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-015-0268-2

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