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Respiratory Research
Published in: Respiratory Research 1/2020

Open Access 01-12-2020 | Chronic Obstructive Lung Disease | Letter to the Editor

The stability of blood Eosinophils in chronic obstructive pulmonary disease

Authors: Gabriella H. Long, Thomas Southworth, Umme Kolsum, Gavin C. Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling, Dave Singh

Published in: Respiratory Research | Issue 1/2020

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Abstract

Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.
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Metadata
Title
The stability of blood Eosinophils in chronic obstructive pulmonary disease
Authors
Gabriella H. Long
Thomas Southworth
Umme Kolsum
Gavin C. Donaldson
Jadwiga A. Wedzicha
Christopher E. Brightling
Dave Singh
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2020
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-020-1279-4

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