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BMC Medicine
Published in: BMC Medicine 1/2015

Open Access 01-12-2015 | Review

Targeting molecular resistance in castration-resistant prostate cancer

Authors: Thenappan Chandrasekar, Joy C. Yang, Allen C. Gao, Christopher P. Evans

Published in: BMC Medicine | Issue 1/2015

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Abstract

Multiple mechanisms of resistance contribute to the inevitable progression of hormone-sensitive prostate cancer to castration-resistant prostate cancer (CRPC). Currently approved therapies for CRPC include systemic chemotherapy (docetaxel and cabazitaxel) and agents targeting the resistance pathways leading to CRPC, including enzalutamide and abiraterone. While there is significant survival benefit, primary and secondary resistance to these therapies develops rapidly. Up to one-third of patients have primary resistance to enzalutamide and abiraterone; the remaining patients eventually progress on treatment. Understanding the mechanisms of resistance resulting in progression as well as identifying new targetable pathways remains the focus of current prostate cancer research. We review current knowledge of mechanisms of resistance to the currently approved treatments, development of adjunctive therapies, and identification of new pathways being targeted for therapeutic purposes.
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Metadata
Title
Targeting molecular resistance in castration-resistant prostate cancer
Authors
Thenappan Chandrasekar
Joy C. Yang
Allen C. Gao
Christopher P. Evans
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2015
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-015-0457-6

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