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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2015

Open Access 01-12-2015 | Research article

Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model

Authors: Su Kang Kim, Hosik Seok, Hae Jeong Park, Hye Sook Jeon, Sang Wook Kang, Byung-Cheol Lee, Jooil Yi, Sang Yeol Song, Sang Hyub Lee, Young Ock Kim, Joo-Ho Chung

Published in: BMC Complementary Medicine and Therapies | Issue 1/2015

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Abstract

Background

Benign prostatic hyperplasia (BPH) is one of the common male diseases, which is provoked by dihydrotestosterone (DHT) and androgen signals. Several studies showed that curcumin has various effects of prevention and treatment to diseases. We investigated whether curcumin may repress the development of BPH in male Wistar rats.

Methods

Seven weeks male Wistar rats were and divided into 4 groups (normal group, BPH group, finasteride group, curcumin group; n = 8 for each group). In order to induce BPH in rats, rats were castrated and testosterone was injected subcutaneously everyday (s.c., 20 mg/kg). Rats in the curcumin group were treated 50 mg/kg, administered orally for 4 weeks. After 4 weeks, all rats were sacrificed and their prostate and serum were analyzed.

Results

Compared to the finasteride group as positive group, the curcumin group showed similarly protective effect on BPH in histopathologic morphology, prostate volume. Results of immunohistochemistry and western-blot showed decreased expressions of VEGF, TGF-ß1, and IGF1 were also decreased in the curcumin group.

Conclusions

These results suggested that curcumin inhibited the development of BPH and might a useful herbal treatment or functional food for BPH.
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Metadata
Title
Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model
Authors
Su Kang Kim
Hosik Seok
Hae Jeong Park
Hye Sook Jeon
Sang Wook Kang
Byung-Cheol Lee
Jooil Yi
Sang Yeol Song
Sang Hyub Lee
Young Ock Kim
Joo-Ho Chung
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2015
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-015-0825-y

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