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BMC Women's Health
Published in: BMC Women's Health 1/2023

Open Access 01-12-2023 | Breast Cancer | Research

Investigating the trends of incidence rates of breast cancer in Southern Iran: a population based survey

Authors: Sezaneh Haghpanah, Mahnaz Hosseini-Bensenjan, Mani Ramzi, Zahra Khosravizadegan, Abbas Rezaianzadeh

Published in: BMC Women's Health | Issue 1/2023

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Abstract

Background

The overall incidence of breast cancer is different all over the world and even within a nation. The present study aims to investigate the stratum-specific incidence trends of breast cancer in southern Iran.

Methods

In this retrospective cohort study, the data of Fars Population-Based Cancer Registry was used during 2001–2018. New cancer cases with ICD-O-3 codes C50.0 to C50.9 were categorized based on age group, morphology, and topography. Age-specific incidence rates of breast cancer were calculated during 2001–2018. Annual overall and truncated age-standardized incidence rates and their 95% Confidence Intervals (CIs) were also calculated. Afterward, the Annual Percentage Changes (APCs) of the age-specific and age-standardized incidence rates of breast cancer during 2001–2018 were calculated using Joinpoint regression software.

Results

An increasing trend was observed in the incidence of breast cancer among women during 2001–2018 (APC of age-standardized incidence rates: 9.5 (95% CI: 7.5, 11.5)).However, the trend was increasing less during the recent years. The APC of age-standardized rates decreased from 15.03 (95% CI: 10.4, 19.8) in 2007 to 6.15(95% CI: 4.0, 8.4) in 2018. The most common morphology of breast cancer was invasive ductal carcinoma (77.3% in females and 75.1% in males) and its trend was similar to the general trend of different types of breast cancer. The most common site of breast cancer was the upper outer quadrant. Most breast cancer cases were female and males accounted for 2.45% of the cases. Among females, 40–55 was the most prevalent age group.

Conclusion

The incidence of breast cancer among women living in southern Iran showed an increasing trend from 2001 to 2018. However, the rate of increase exhibited a milder slope during the more recent years. Based on the higher prevalence of breast cancer in the 40–55 age group observed in the present study, it offers valuable insight into the potential reduction of the breast cancer screening age from 50 to 40 years for healthy Iranian women. However, before implementing such a policy change, it is crucial to conduct additional studies that specifically examine the cost-effectiveness, as well as the potential benefits and risks associated with this alteration.
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Literature
1.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2018;68(6):394–424.CrossRef
2.
Rosai J. Rosai and Ackerman’s surgical pathology e-book. Elsevier Health Sciences; 2011.
3.
Vinay K, Abbas AK, Fauston N, Aster JJND. India. Robbins and Cotran pathologic basis of disease. 2005:628 – 36.
4.
5.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet (London England). 2008;371(9612):569–78.CrossRefPubMed
6.
Coughlin SS, Smith SA. The insulin-like growth factor Axis, Adipokines, Physical Activity, and obesity in relation to Breast Cancer incidence and recurrence. Cancer Clin Oncol. 2015;4(2):24–31.PubMedPubMedCentral
7.
Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, et al. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabol. 2014;19(3):407–17.CrossRef
8.
Hamajima N, Hirose K, Tajima K, Rohan T, Calle EE, Heath CW Jr., et al. Alcohol, Tobacco and Breast cancer–collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with Breast cancer and 95,067 women without the Disease. Br J Cancer. 2002;87(11):1234–45.CrossRefPubMed
9.
Hunter DJ, Colditz GA, Hankinson SE, Malspeis S, Spiegelman D, Chen W, et al. Oral contraceptive use and Breast cancer: a prospective study of young women. Cancer Epidemiol Biomarkers Prevention: Publication Am Association Cancer Res Cosponsored Am Soc Prev Oncol. 2010;19(10):2496–502.CrossRef
10.
Lei S, Zheng R, Zhang S, Wang S, Chen R, Sun K et al. Global patterns of Breast cancer incidence and mortality: a population-based cancer registry data analysis from 2000 to 2020. Cancer communications (London, England). 2021;41(11):1183–94.
11.
Hosseini-Bensenjan M, Vardanjani HM, Haghpanah S, Khosravizadegan Z, Bagheri-Lankarani K. Investigating trends of Incidence Rates of Esophageal Cancer divided by Squamous Cell Carcinoma and adenocarcinoma in Southern Iran: a 10-Year experience. J Gastrointest cancer. 2022;53(1):230–4.CrossRefPubMed
12.
Hosseini-Bensenjan M, Vardanjani HM, Khosravizadegan Z, Bagheri-Lankarani K. Incidence trends of gastric Cancer in Southern Iran: Adenocarcinoma and Non-cardia Gastric Cancer are more rising among younger ages. J Gastrointest cancer. 2021.
13.
Zahedi R, Molavi Vardanjani H, Baneshi MR, Haghdoost AA, Malekpour Afshar R, Ershad Sarabi R, et al. Incidence trend of Breast Cancer in women of eastern Mediterranean region countries from 1998 to 2019: a systematic review and meta-analysis. BMC Womens Health. 2020;20(1):53.CrossRefPubMedPubMedCentral
14.
15.
Corbex M, Bouzbid S, Boffetta P. Features of Breast cancer in developing countries, examples from North-Africa. Eur J cancer (Oxford England: 1990). 2014;50(10):1808–18.CrossRef
16.
Lankarani KB, Khosravizadegan Z, Rezaianzadeh A, Honarvar B, Moghadami M, Faramarzi H, et al. Data coverage of a cancer registry in southern Iran before and after implementation of a population-based reporting system: a 10-year trend study. BMC Health Serv Res. 2013;13:169.CrossRefPubMedPubMedCentral
17.
Molavi Vardajani H, Haghdoost AA, Shahravan A, Rad M. Cleansing and preparation of data for statistical analysis: a step necessary in oral health sciences research %J. J Oral Health Oral Epidemiol. 2016;5(4):171–85.
18.
Ries LA, Wingo PA, Miller DS, Howe HL, Weir HK, Rosenberg HM et al. The annual report to the nation on the status of cancer, 1973–1997, with a special section on colorectal cancer. Cancer. 2000;88(10):2398 – 424.
19.
Yang L, Parkin DM, Li L, Chen Y. Time trends in cancer mortality in China: 1987–1999. Int J Cancer. 2003;106(5):771–83.CrossRefPubMed
20.
Saberian M, Mehrabani K, Shahraki HR. Clustering time trends of Breast cancer incidence in Africa: a 27-year longitudinal study in 53 countries. Afr Health Sci. 2021;21(1):47–53.CrossRefPubMedPubMedCentral
21.
Al-Hashimi MMY. Trends in Breast Cancer incidence in Iraq during the period 2000–2019. Asian Pac J cancer Prevention: APJCP. 2021;22(12):3889–96.CrossRef
22.
Pham DX, Ho TH, Bui TD, Ho-Pham LT, Nguyen TV. Trends in Breast cancer incidence in Ho Chi Minh City 1996–2015: a registry-based study. PLoS ONE. 2021;16(2):e0246800.CrossRefPubMedPubMedCentral
23.
Abdulrahman GOJ. Breast cancer in Wales: time trends and geographical distribution. Gland Surg. 2014;3(4):237–42.PubMed
24.
Hendrick RE, Helvie MA, Monticciolo DL. Breast Cancer Mortality Rates have stopped declining in U.S. women younger than 40 years. Radiology. 2021;299(1):143–9.CrossRefPubMed
25.
26.
Mullooly M, Khodr ZG, Dallal CM, Nyante SJ, Sherman ME, Falk R, et al. Epidemiologic risk factors for in situ and invasive breast cancers among Postmenopausal women in the National institutes of Health-AARP Diet and Health Study. Am J Epidemiol. 2017;186(12):1329–40.CrossRefPubMedPubMedCentral
27.
Phillips LS, Millikan RC, Schroeder JC, Barnholtz-Sloan JS, Levine BJ. Reproductive and hormonal risk factors for ductal carcinoma in situ of the breast. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009;18(5):1507–14.
28.
Kelsey JL, Bernstein L. Epidemiology and prevention of Breast cancer. Annu Rev Public Health. 1996;17:47–67.CrossRefPubMed
29.
Gosling S, Scott R, Greenwood C, Bouzy P, Nallala J, Lyburn ID, et al. Calcification microstructure reflects breast tissue microenvironment. J Mammary Gland Biol Neoplasia. 2019;24(4):333–42.CrossRefPubMedPubMedCentral
30.
31.
Berg WA, Zhang Z, Lehrer D, Jong RA, Pisano ED, Barr RG, et al. Detection of Breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated Breast cancer risk. JAMA. 2012;307(13):1394–404.CrossRefPubMedPubMedCentral
32.
Bae SY, Kim S, Lee JH, Lee HC, Lee SK, Kil WH, et al. Poor prognosis of single hormone receptor- positive Breast cancer: similar outcome as triple-negative Breast cancer. BMC Cancer. 2015;15:138.CrossRefPubMedPubMedCentral
33.
Dass SA, Tan KL, Selva Rajan R, Mokhtar NF, Mohd Adzmi ER, Wan Abdul Rahman WF et al. Triple Negative Breast Cancer: A Review of Present and Future Diagnostic Modalities. Medicina (Kaunas, Lithuania). 2021;57(1).
34.
Darbre PD. Recorded quadrant incidence of female Breast cancer in Great Britain suggests a disproportionate increase in the upper outer quadrant of the breast. Anticancer Res. 2005;25(3c):2543–50.PubMed
35.
Sohn VY, Arthurs ZM, Sebesta JA, Brown TA. Primary Tumor location impacts Breast cancer survival. Am J Surg. 2008;195(5):641–4.CrossRefPubMed
36.
Rummel S, Hueman MT, Costantino N, Shriver CD, Ellsworth RE. Tumour location within the breast: does tumour site have prognostic ability? Ecancermedicalscience. 2015;9:552.CrossRefPubMedPubMedCentral
37.
Wu S, Zhou J, Ren Y, Sun J, Li F, Lin Q, et al. Tumor location is a prognostic factor for survival of Chinese women with T1-2N0M0 Breast cancer. Int J Surg (London England). 2014;12(5):394–8.CrossRef
38.
Lee AH. Why is carcinoma of the breast more frequent in the upper outer quadrant? A case series based on needle core biopsy diagnoses. Breast (Edinburgh Scotland). 2005;14(2):151–2.CrossRefPubMed
39.
Bab S, Abdifard E, Elyasianfar S, Mohammadi P, Heidari M. Time trend analysis of Breast cancer in Iran and its six topographical regions: a population-based study. J Med Life. 2019;12(2):140–9.CrossRefPubMedPubMedCentral
40.
Sripan P, Sriplung H, Pongnikorn D, Virani S, Bilheem S, Chaisaengkhaum U, et al. Trends in female Breast Cancer by Age Group in the Chiang Mai Population. Asian Pac J cancer Prevention: APJCP. 2017;18(5):1411–6.
41.
Lima SM, Kehm RD, Terry MB. Global Breast cancer incidence and mortality trends by region, age-groups, and fertility patterns. EClinicalMedicine. 2021;38:100985.CrossRefPubMedPubMedCentral
42.
Shamshirian A, Heydari K, Shams Z, Aref AR, Shamshirian D, Tamtaji OR et al. Breast cancer risk factors in Iran: a systematic review & meta-analysis. Horm Mol Biol Clin Investig. 2020;41(4).
43.
Pfeiffer RM, Webb-Vargas Y, Wheeler W, Gail MH. Proportion of U.S. Trends in Breast Cancer incidence attributable to long-term changes in risk factor distributions. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2018;27(10):1214–22.
Metadata
Title
Investigating the trends of incidence rates of breast cancer in Southern Iran: a population based survey
Authors
Sezaneh Haghpanah
Mahnaz Hosseini-Bensenjan
Mani Ramzi
Zahra Khosravizadegan
Abbas Rezaianzadeh
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2023
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/s12905-023-02757-7

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