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BMC Women's Health
Published in: BMC Women's Health 1/2023

Open Access 01-12-2023 | Vitamin D Deficiency | Research

Interaction of estradiol and vitamin D with low skeletal muscle mass among middle-aged and elderly women

Authors: Jiaxing Zhang, Yalong Cheng, Chen Chen, Qingan Wang, Chan Yang, Jiangwei Qiu, Juan Li, Xiaowei Liu, Yuhong Zhang, Lan Liu, Yi Zhao

Published in: BMC Women's Health | Issue 1/2023

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Abstract

Background

Since the connection between muscle atrophy and vitamin D and estradiol status ambiguous, this study was thus conducted to determine whether low skeletal muscle mass (SMM) in middle-aged and elderly women was affected by estradiol and vitamin D levels together.

Methods

Baseline data from a sub-cohort of the China Northwest Natural Population Cohort: Ningxia Project (CNC-NX) were analyzed. Serum 25-hydroxyvitamin D (25(OH) D) and estradiol were measured by chemiluminescence immunoassay analyzer. Bivariate logistic regression and multiplicative interaction analyses were used to assess the impact of estradiol level and vitamin D status on low SMM, as well as the combined impact of estradiol and low vitamin D status on low SMM.

Results

A total of 287 (9.49%) participants had low SMM, which had lower levels of estradiol and vitamin D concentration than normal SMM group. While, after adjusting the confounding variables, these correlations were maintained in estradiol Q1, Q2, Q3 and vitamin D Q1. Furthermore, the significant combined effect of the highest quartile of estradiol concentrations and non-vitamin D deficiency, and interactions between vitamin D Q1 and estradiol Q2, vitamin D Q1 and estradiol Q3, vitamin D Q2 and estradiol Q1, vitamin D Q3 and estradiol Q3 on low SMM were stably reflected (P for interaction < 0.05).

Conclusions

Estradiol and vitamin D were interrelated with low SMM in middle-aged and elderly women. Combination of estradiol and vitamin D supplements should be encouraged for middle-aged and elderly women who are at risk of muscle atrophy or experiencing muscle atrophy.
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Metadata
Title
Interaction of estradiol and vitamin D with low skeletal muscle mass among middle-aged and elderly women
Authors
Jiaxing Zhang
Yalong Cheng
Chen Chen
Qingan Wang
Chan Yang
Jiangwei Qiu
Juan Li
Xiaowei Liu
Yuhong Zhang
Lan Liu
Yi Zhao
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2023
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/s12905-023-02646-z

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