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BMC Palliative Care

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Open Access 01-12-2023 | Care | Research

Non-pharmacological interventions to manage psychological distress in patients living with cancer: a systematic review

Authors: Carole A. Paley, Jason W. Boland, Martina Santarelli, Fliss E. M. Murtagh, Lucy Ziegler, Emma J. Chapman

Published in: BMC Palliative Care | Issue 1/2023

Abstract

Background

Psychological distress is common in patients with cancer; interfering with physical and psychological wellbeing, and hindering management of physical symptoms. Our aim was to systematically review published evidence on non-pharmacological interventions for cancer-related psychological distress, at all stages of the disease.

Methods

We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review was registered on PROSPERO (CRD42022311729). Searches were made using eight online databases to identify studies meeting our inclusion criteria.

Data were collected on outcome measures, modes of delivery, resources and evidence of efficacy. A meta-analysis was planned if data allowed. Quality was assessed using the Mixed Methods Appraisal Tool (MMAT).

Results

Fifty-nine studies with 17,628 participants were included. One third of studies included mindfulness, talking or group therapies. Half of all studies reported statistically significant improvements in distress. Statistically significant intervention effects on distress were most prevalent for mindfulness techniques. Four of these mindfulness studies had moderate effect sizes (d = -0.71[95% CI: -1.04, -0.37] p < 0.001) (d = -0.60 [95% CI: -3.44, -0.89] p < 0.001) (d = -0.77 [CI: -0.146, -1.954] p < 0.01) (d = -0.69 [CI: -0.18, -1.19] p = 0.008) and one had a large effect size (d = -1.03 [95% CI: -1.51, -0.54] p < 0.001). Heterogeneity of studies precluded meta-analysis. Study quality was variable and some had a high risk of bias.

Conclusions

The majority of studies using a mindfulness intervention in this review are efficacious at alleviating distress. Mindfulness—including brief, self-administered interventions—merits further investigation, using adequately powered, high-quality studies.

Systematic review registration

This systematic review is registered on PROSPERO, number CRD42022311729.

Available only for authorised users

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Title: Non-pharmacological interventions to manage psychological distress in patients living with cancer: a systematic review
Authors: Carole A. Paley
Jason W. Boland
Martina Santarelli
Fliss E. M. Murtagh
Lucy Ziegler
Emma J. Chapman
Publication date: 01-12-2023
Publisher: BioMed Central
Keyword: Care
Published in: BMC Palliative Care / Issue 1/2023
Electronic ISSN: 1472-684X
DOI: https://doi.org/10.1186/s12904-023-01202-8

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Non-pharmacological interventions to manage psychological distress in patients living with cancer: a systematic review

Abstract

Background

Methods

Results

Conclusions

Systematic review registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Systematic review registration

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