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BMC Oral Health

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Open Access 01-12-2024 | Systematic Review

Outcome assessment methods of bioactive and biodegradable materials as pulpotomy agents in primary and permanent teeth: a scoping review

Authors: Yasmine Elhamouly, May M. Adham, Karin M L Dowidar, Rania M. El Backly

Published in: BMC Oral Health | Issue 1/2024

Abstract

Background

Pulpotomy procedures aiming to preserve and regenerate the dentin-pulp complex have recently increased exponentially due to developments in the field of biomaterials and tissue engineering in primary and permanent teeth. Although the number of studies in this domain has increased, there is still scarcity of evidence in the current literature.

Objectives

(1) Report the methods of outcome assessment of pulpotomy clinical trials in both primary and permanent teeth; (2) Identify the various bioactive agents and biodegradable scaffolds used in pulpotomy clinical trials in both primary and permanent teeth.

Materials and methods

A scoping review of the literature was performed, including a search of primary studies on PubMed, Scopus, Web of Science, ProQuest and Clinicaltrials.gov. A search for controlled trials or randomized controlled trials published between 2012 and 2023 involving primary or permanent teeth receiving partial or full pulpotomy procedures using bioactive/regenerative capping materials was performed.

Results

127 studies out of 1038 articles fulfilled all the inclusion criteria and were included in the current scoping review. More than 90% of the studies assessed clinical and radiographic outcomes. Histological, microbiological, or inflammatory outcomes were measured in only 9.4% of all included studies. Majority of the studies (67.7%) involved primary teeth. 119 studies used non-degradable bioactive cements, while biodegradable scaffolds were used by 32 studies, natural derivates and plant extracts studies were used in only 7 studies. Between 2012 (4 studies) and 2023 (11 studies), there was a general increase in the number of articles published. India, Egypt, Turkey, and Iran were found to have the highest total number of articles published (28, 28,16 and 10 respectively).

Conclusions

Pulpotomy studies in both primary and permanent teeth relied mainly on subjective clinical and radiographic outcome assessment methods and seldom analyzed pulpal inflammatory status objectively. The use of biodegradable scaffolds for pulpotomy treatments has been increasing with an apparent global distribution of most of these studies in low- to middle-income countries. However, the development of a set of predictable outcome measures as well as long-term evidence from well conducted clinical trials for novel pulpotomy dressing materials are still required.

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Lin GSS, Yew YQ, Lee HY, Low T, Pillai MPM, Laer TS, et al. Is pulpotomy a promising modality in treating permanent teeth? An umbrella review. Odontology. 2022;110(2):393–409.PubMedCrossRef

Tricco AC, Zarin W, Ghassemi M, Nincic V, Lillie E, Page MJ, et al. Same family, different species: methodological conduct and quality varies according to purpose for five types of knowledge synthesis. J Clin Epidemiol. 2018;96:133–42.PubMedCrossRef

Cushley S, Duncan HF, Lappin MJ, Tomson PL, Lundy FT, Cooper P, et al. Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: a systematic review. J Dent. 2019;88:103158.PubMedCrossRef

El karim Ikhlas A, CPR, About Imad, Tomson Phillip L, Lundy Fionnuala T. Duncan Henry F. Deciphering Reparative Processes in the Inflamed Dental Pulp. 2021;2.

Alqaderi H, Lee CT, Borzangy S, Pagonis TC. Coronal pulpotomy for cariously exposed permanent posterior teeth with closed apices: a systematic review and meta-analysis. J Dent. 2016;44:1–7.PubMedCrossRef

Lin GSS, Hisham ARB, Ch Er CIY, Cheah KK, Ghani N, Noorani TY. Success rates of coronal and partial pulpotomies in mature permanent molars: a systematic review and single-arm meta-analysis. Quintessence Int. 2021;0(0):0.

Fuks AB. Current concepts in vital primary pulp therapy. Eur J Paediatr Dent. 2002;3(3):115–20.PubMed

American Association of Endodontists. Guide to Clinical Endodontics 6th ed. Chicago, Ill.: American Association of Endodontists2013. https://www.aae.org/specialty/clinical-resources/guide-clinical-endodontics/

Rechenberg DK, Zehnder M. Call for a review of diagnostic nomenclature and terminology used in endodontics. Int Endod J. 2020;53(10):1315–7.PubMedCrossRef

10.

Cushley S, Duncan HF, Lundy FT, Nagendrababu V, Clarke M, El Karim I. Outcomes reporting in systematic reviews on vital pulp treatment: a scoping review for the development of a core outcome set. Int Endod J. 2022;55(9):891–909.PubMedPubMedCentralCrossRef

11.

Duncan HF. Present status and future directions-vital pulp treatment and pulp preservation strategies. Int Endod J. 2022;55(3):497–511.PubMedPubMedCentralCrossRef

12.

Bjorndal L, Simon S, Tomson PL, Duncan HF. Management of deep caries and the exposed pulp. Int Endod J. 2019;52(7):949–73.PubMedCrossRef

13.

Jha S, Goel N, Dash BP, Sarangal H, Garg I, Namdev R. An update on newer Pulpotomy agents in primary teeth: a Literature Review. J Pharm Bioallied Sci. 2021;13(Suppl 1):S57–61.PubMedPubMedCentralCrossRef

14.

Igna A. Vital Pulp Therapy in primary dentition: Pulpotomy-A 100-Year challenge. Child (Basel). 2021;8(10).

15.

Peters M, Godfrey C, McInerney P, Munn Z, Tricco A, Khalil H. In: Aromataris E, Munn Z, editors. Chapter 11: scoping reviews (2020 version). JBI Manual for Evidence Synthesis: JBI; 2020.

16.

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffman T, Mulrow C et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372.

17.

Herlesová J. Histology of dental pulp in clinically intact deciduous and permanent teeth in children. Acta Universitatis Carol Med. 1968;14(6):229–34.

18.

Elhamouly Y, El Backly RM, Talaat DM, Omar SS, El Tantawi M, Dowidar KML. Tailored 70S30C bioactive glass induces severe inflammation as pulpotomy agent in primary teeth: an interim analysis of a randomised controlled trial. Clin Oral Invest. 2021;25(6):3775–87.CrossRef

19.

Peters MDJ, Marnie C, Tricco AC, Pollock D, Munn Z, Alexander L, et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Synth. 2020;18(10):2119–26.PubMedCrossRef

20.

Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for scoping reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467–73.PubMedCrossRef

21.

Manohar S, Bazaz N, Neeraja G, Subramaniam P, Sneharaj N. A comparative evaluation of four regenerative materials for pulpotomy in primary molars: an in vivo study. Dent Res J. 2022;19:102.CrossRef

22.

NCT04115358. Evaluation of hyaluronic acid pulpotomies in primary molars. https://clinicaltrials.gov/study/NCT04115358. Completed. 2021-08–03.

23.

NCT04784949. PRF pulpotomy using different bioceramic materials in permanent molars. https://clinicaltrials.gov/study/NCT04784949. Completed. 2021-03–5.

24.

NCT03119779. Effect of pulpotomy using theracal versus mta on survival rate of cariously-exposed vital permanent molars. https://clinicaltrials.gov/study/NCT03119779. Completed. 2017-07-25.

25.

NCT05266859. Efficacy of PRF and MTA as compared to calcium hydroxide for pulpotomy in human irreversibly inflamed permanent teeth. https://clinicaltrials.gov/study/NCT05266859. Completed. 2022-08-17.

26.

Nguyen TD, Judd PL, Barrett EJ, Sidhu N, Casas MJ. Comparison of Ferric Sulfate Combined Mineral Trioxide Aggregate Pulpotomy and Zinc Oxide Eugenol Pulpectomy of primary Maxillary incisors: an 18-month Randomized, Controlled Trial. Pediatr Dent. 2017;39(1):34–8.PubMed

27.

Nosrat A, Seifi A, Asgary S. Pulpotomy in caries-exposed immature permanent molars using calcium-enriched mixture cement or mineral trioxide aggregate: a randomized clinical trial. Int J Pediatr Dent. 2013;23(1):56–63.CrossRef

28.

Oliveira TM, Moretti AB, Sakai VT, Lourenço Neto N, Santos CF, Machado MA, et al. Clinical, radiographic and histologic analysis of the effects of pulp capping materials used in pulpotomies of human primary teeth. Eur Arch Paediatr Dent. 2013;14(2):65–71.PubMedCrossRef

29.

Ozgur B, Uysal S, Gungor HC. Partial pulpotomy in Immature Permanent molars after Carious exposures using different Hemorrhage Control and Capping materials. Pediatr Dent. 2017;39(5):364–70.PubMed

30.

Perea MB, Mendoza BS, Garcia-Godoy F, Mendoza AM, Iglesias-Linares A. Clinical and radiographic evaluation of white MTA versus formocresol pulpotomy: a 48-month follow-up study. Am J Dent. 2017;30(3):131–6.

31.

Petel R, Ziskind K, Bernfeld N, Suliman H, Fuks AB, Moskovitz M. A randomised controlled clinical trial comparing pure Portland cement and formocresol pulpotomies followed from 2 to 4 years. Eur Arch Paediatr Dent. 2021;22(4):547–52.PubMedCrossRef

32.

Pratima B, Chandan GD, Nidhi T, Nitish I, Sankriti M, Nagaveni S, et al. Postoperative assessment of diode laser zinc oxide eugenol and mineral trioxide aggregate pulpotomy procedures in children: a comparative clinical study. J Indian Soc Pedod Prev Dent. 2018;36(3):308–14.PubMedCrossRef

33.

Rajasekharan S, Martens LC, Vandenbulcke J, Jacquet W, Bottenberg P, Cauwels RG. Efficacy of three different pulpotomy agents in primary molars: a randomized control trial. Int Endod J. 2017;50(3):215–28.PubMedCrossRef

34.

Rao Q, Kuang J, Mao C, Dai J, Hu L, Lei Z, et al. Comparison of iRoot BP Plus and Calcium Hydroxide as Pulpotomy materials in Permanent incisors with complicated Crown fractures: a retrospective study. J Endod. 2020;46(3):352–7.PubMedCrossRef

35.

RojaRamya KS, Chandrasekhar R, Uloopi KS, Vinay C. Treatment outcomes of Pulpotomy with Propolis in comparison with MTA in human primary molars: a 24-month follow-up Randomized Controlled Trial. Int J Clin Pediatr Dentistry. 2022;15(Suppl 1):S3–7.

36.

Rubanenko M, Petel R, Tickotsky N, Fayer I, Fuks AB, Moskovitz M. A randomized controlled clinical trial comparing Tricalcium Silicate and Formocresol pulpotomies followed for two to four years. Pediatr Dent. 2019;41(6):446–50.PubMed

37.

Sharaan M, Ali A. Mineral Trioxide Aggregate vs calcium-enriched mixture pulpotomy in Young Permanent molars with a diagnosis of irreversible pulpitis: a Randomized Clinical Trial. Iran Endod J. 2022;17(3):106–13.PubMedPubMedCentral

38.

Singh R, Singh R, Kavita K, Kommula A, Kulkarni G, Jois HS. To compare Mineral Trioxide Aggregate, platelet-rich fibrin, and Calcium Hydroxide in Teeth with irreversible pulpitis: a clinical study. J Pharm Bioallied Sci. 2020;12(Suppl 1):S436–9.PubMedPubMedCentralCrossRef

39.

Singh DVV, Taneja S, Fatima S. Comparative evaluation of treatment outcome of partial pulpotomy using different agents in permanent teeth-a randomized controlled trial. Clin Oral Invest. 2023;27(9):5171–80.CrossRef

40.

NCT05582317. Efficacy of combination of biodentine and simvastatin as a pulp capping materials in vital pulpotomy of primary molars. https://clinicaltrials.gov/study/NCT05582317. Completed. 2022-10-17.

41.

Taha NA, Al-Rawash MH, Imran ZA. Outcome of full pulpotomy in mature permanent molars using 3 calcium silicate-based materials: a parallel, double blind, randomized controlled trial. Int Endod J. 2022;55(5):416–29.PubMedCrossRef

42.

NCT04345263. Outcome of full pulpotomy using calcium silicate based materials. https://clinicaltrials.gov/study/NCT04345263. Unknown. 2021-09-22.

43.

Togaru H, Muppa R, Srinivas N, Naveen K, Reddy VK, Rebecca VC. Clinical and radiographic evaluation of success of two commercially available Pulpotomy agents in primary teeth: an in vivo study. J Contemp Dent Pract. 2016;17(7):557–63.PubMedCrossRef

44.

NCT04010929. Efficacy of Er,Cr:YSGG laser in partial pupotomy. https://clinicaltrials.gov/study/NCT04010929. Completed. 2019-07-08.

45.

Tzanetakis GN, Koletsi D, Georgopoulou M. Treatment outcome of partial pulpotomy using two different calcium silicate materials in mature permanent teeth with symptoms of irreversible pulpitis: a randomized clinical trial. Int Endod J. 2023;56(10):1178–96.PubMedCrossRef

46.

Uesrichai N, Nirunsittirat A, Chuveera P, Srisuwan T, Sastraruji T, Chompu-Inwai P. Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial. Int Endod J. 2019;52(6):749–59.PubMedCrossRef

47.

NCT02201498. Randomized clinical trial for primary molar pulpotomy, biodentine vs formocresol-ZOE. https://clinicaltrials.gov/study/NCT02201498. Completed. 2018-01-12.

48.

Vafaei A, Nikookhesal M, Erfanparast L, Løvschall H, Ranjkesh B. Vital pulp therapy following pulpotomy in immature first permanent molars with deep caries using novel fast-setting calcium silicate cement: a retrospective clinical study. J Dent. 2022;116:103890.PubMedCrossRef

49.

Vilella-Pastor S, Sáez S, Veloso A, Guinot-Jimeno F, Mercadé M. Long-term evaluation of primary teeth molar pulpotomies with Biodentine and MTA: a CONSORT randomized clinical trial. Eur Arch Paediatr Dent. 2021;22(4):685–92.PubMedCrossRef

50.

Vu TT, Nguyen MT, Sangvanich P, Nguyen QN, Thunyakitpisal P. Acemannan used as an Implantable Biomaterial for Vital Pulp Therapy of Immature Permanent Teeth Induced continued Root formation. Pharmaceutics. 2020;12(7):644.PubMedPubMedCentralCrossRef

51.

NCT04397094. Theracal pulpotomy in primary molars. https://clinicaltrials.gov/study/NCT04397094. Completed. 2020-07–29.

52.

Yang Y, Xia B, Xu Z, Dou G, Lei Y, Yong W. The effect of partial pulpotomy with iRoot BP plus in traumatized immature permanent teeth: a randomized prospective controlled trial. Dent Traumatology: Official Publication Int Association Dent Traumatol. 2020;36(5):518–25.CrossRef

53.

Yildirim C, Basak F, Akgun OM, Polat GG, Altun C. Clinical and radiographic evaluation of the effectiveness of Formocresol, Mineral Trioxide Aggregate, Portland Cement, and Enamel Matrix Derivative in primary Teeth pulpotomies: a Two Year Follow-Up. J Clin Pediatr Dent. 2016;40(1):14–20.PubMedCrossRef

54.

NCT04795830. Bioactive materials in pulp therapy of primary teeth. https://clinicaltrials.gov/study/NCT04795830. Completed. 2023-07-21.

55.

Abd Al Gawad RY, Hanafy RMH. Success rate of three capping materials used in pulpotomy of primary molars: a randomized clinical trial. Saudi Dent J. 2021;33(7):560–7.PubMedCrossRef

56.

NCT05981352. Evaluation of different materials in pulpotomy of primary molars. https://clinicaltrials.gov/study/NCT05981352. Not yet recruiting. 2023.

57.

NCT04308863. Evaluation of chitosan scaffold and mineral trioxide aggregate pulpotomy in mature permanent molars with irreversible pulpitis. https://clinicaltrials.gov/study/NCT04308863. Completed 2022-05-19.

58.

Abuelniel GM, Duggal MS, Kabel N. A comparison of MTA and Biodentine as medicaments for pulpotomy in traumatized anterior immature permanent teeth: a randomized clinical trial. Dent Traumatology: Official Publication Int Association Dent Traumatol. 2020;36(4):400–10.CrossRef

59.

Abuelniel GM, Duggal MS, Duggal S, Kabel NR. Evaluation of Mineral Trioxide Aggregate and Biodentine as pulpotomy agents in immature first permanent molars with carious pulp exposure: a randomised clinical trial. Eur J Paediatr Dent. 2021;22(1):19–25.PubMed

60.

Airen P, Shigli A, Airen B. Comparative evaluation of formocresol and mineral trioxide aggregate in pulpotomized primary molars–2 year follow up. J Clin Pediatr Dent. 2012;37(2):143–7.PubMedCrossRef

61.

Airsang AJ, Shankaregowda AM, Meena N, Lingaiah U, Lakshminarasimhaiah V, Harti S. Comparative Assessment of Complete Pulpotomy in mature permanent teeth with Carious exposure using calcium Silicate Cement: a Randomized Clinical Trial. World J Dentistry. 2022;13(S2):S135–43.CrossRef

62.

Akcay M, Sari S. The effect of sodium hypochlorite application on the success of calcium hydroxide and mineral trioxide aggregate pulpotomies in primary teeth. Pediatr Dent. 2014;36(4):316–21.PubMed

63.

Aksoy B, Güngör HC, Uysal S, Gonzales CD, Ölmez S. Ferric sulfate pulpotomy in primary teeth with different base materials: a 2-year randomized controlled trial. Quintessence Int. 2022;53(9):782–9.PubMed

64.

NCT03426046. Treatment of immature permanent teeth with three different pulp capping materials with partial pulpotomy. https://clinicaltrials.gov/study/NCT03426046. Completed. 2018-02-12.

65.

Alajaji N. Comparing the Outcomes of Three Pulpotomy Agents in Primary Molars: A Retrospective Study. University of Illinois at Chicago. Thesis. 2021.

66.

NCT03782714. Low-level laser therapy versus formocresol in primary molar pulpotomies. https://clinicaltrials.gov/study/NCT03782714. Completed. 2018-12-20.

67.

NCT03779698. BiodentineTM versus formocresol pulpotomy technique in primary molars. https://clinicaltrials.gov/study/NCT03779698. Completed. 2018-12-19.

68.

Alnassar I, Altinawi M, Rekab MS, Alzoubi H, Abdo A. Evaluation of the efficacy of mineral trioxide aggregate and bioceramic putty in primary molar pulpotomy with symptoms of irreversible pulpitis (a randomized-controlled trial). Clin Exp Dent Res. 2023;9(2):276–82.PubMedCrossRef

69.

NCT04634123. The use of Portland cement in primary anterior teeth pulpotomy. https://clinicaltrials.gov/study/NCT04634123. Completed. 2021-12-09.

70.

Anandan V, Inbanathan J, Saket P, Krishnamoorthy V, Gandhi S, Chandrababu VK. Assessment of Clinical and Radiographic Success Rate of Formocresol-based Pulpotomy versus Collagen-based Pulpotomy: an in vivo study. J Contemp Dent Pract. 2021;22(6):680–5.PubMedCrossRef

71.

Aripirala M, Bansal K, Mathur VP, Tewari N, Gupta P, Logani A. Comparative evaluation of diode laser and simvastatin gel in pulpotomy of primary molars: a randomized clinical trial. J Indian Soc Pedod Prev Dent. 2021;39(3):303–9.PubMed

72.

Asgary S, Eghbal MJ. Treatment outcomes of pulpotomy in permanent molars with irreversible pulpitis using biomaterials: a multi-center randomized controlled trial. Acta Odontol Scand. 2012;71(1):130–6.PubMedCrossRef

73.

Asgary S, Eghbal MJ, Shahravan A, Saberi E, Baghban AA, Parhizkar A. Outcomes of root canal therapy or full pulpotomy using two endodontic biomaterials in mature permanent teeth: a randomized controlled trial. Clin Oral Invest. 2022;26(3):3287–97.CrossRef

74.

NCT05347160. Evaluation of different pulpotomy agents used for treatment of immature molars. https://clinicaltrials.gov/study/NCT05347160. Active not recruiting. 2022-04-26.

75.

Awawdeh L, Al-Qudah A, Hamouri H, Chakra RJ. Outcomes of vital pulp therapy using Mineral Trioxide Aggregate or Biodentine: a prospective Randomized Clinical Trial. J Endod. 2018;44(11):1603–9.PubMedCrossRef

76.

Bani M, Aktaş N, Çınar Ç, Odabaş ME. The clinical and radiographic success of primary molar pulpotomy using Biodentine™ and Mineral Trioxide Aggregate: a 24-Month Randomized Clinical Trial. Pediatr Dent. 2022;39(4):284–8.

77.

NCT05479877. Evaluation of hyaluronic acid pulpotomies in primary molars. https://clinicaltrials.gov/study/NCT04115358. Completed. 2021-08–03.

78.

Brar K. Comparing Biodentine and Ferric Sulfate as Pulpotomy agents in primary molars: a retrospective study. University of Illinois at Chicago; 2020.

79.

Carti O, Oznurhan F. Evaluation and comparison of mineral trioxide aggregate and biodentine in primary tooth pulpotomy: clinical and radiographic study. Niger J Clin Pract. 2017;20(12):1604–9.PubMedCrossRef

80.

Caruso S, Dinoi T, Marzo G, Campanella V, Giuca MR, Gatto R, et al. Clinical and radiographic evaluation of biodentine versus calcium hydroxide in primary teeth pulpotomies: a retrospective study. BMC Oral Health. 2018;18:1–7.CrossRef

81.

Celik B, Ataç AS, Cehreli ZC, Uysal S. A randomized trial of mineral trioxide aggregate cements in primary tooth pulpotomies. J Dentistry Child (Chicago Ill). 2013;80(3):126–32.

82.

Celik BN, Mutluay MS, Arikan V, Sari S. The evaluation of MTA and Biodentine as a pulpotomy materials for carious exposures in primary teeth. Clin Oral Invest. 2019;23(2):661–6.CrossRef

83.

Chailertvanitkul P, Paphangkorakit J, Sooksantisakoonchai N, Pumas N, Pairojamornyoot W, Leela-Apiradee N, et al. Randomized control trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars. Int Endod J. 2014;47(9):835–42.PubMedCrossRef

84.

Chak RK, Singh RK, Mutyala J, Killi NK. Clinical Radiographic evaluation of 3Mixtatin and MTA in primary Teeth pulpotomies: a randomized controlled. Int J Clin Pediatr Dentistry. 2022;15(Suppl 1):S80–6.

85.

NCT02783911. Comparison of mineral trioxide aggregate (MTA) & ferric sulfate (FS) pulpotomies. https://clinicaltrials.gov/study/NCT02783911. Terminated. 2021-06-11.

86.

Clancy MR. Comparing the success of BiodentineTM vs. Ferric Sulfate in primary molar pulpotomies. University of Illinois at Chicago; 2018.

87.

NCT05145686. The role of matrix metalloproteinases on the primary teeth pulpotomy treatments. https://clinicaltrials.gov/study/NCT05145686. Completed. 2022-01-03.

88.

Cordell SC. Randomized Controlled Clinical Trial Comparing the Success of Two Pulpotomy Agents for Primary Molars. PhD Thesis: University of Illinois at Chicago; 2019.

89.

Lima SPR, Santos GLD, Ferelle A, Ramos SP, Pessan JP, Dezan-Garbelini CC. Clinical and radiographic evaluation of a new stain-free tricalcium silicate cement in pulpotomies. Brazilian oral Res. 2020;34:e102.CrossRef

90.

Eid A, Mancino D, Rekab MS, Haikel Y, Kharouf N. Effectiveness of three agents in Pulpotomy Treatment of Permanent Molars with Incomplete Root Development: a Randomized Controlled Trial. Healthc (Basel Switzerland). 2022;10(3):431.

91.

El Meligy O, Alamoudi NM, Allazzam SM, El-Housseiny AAM. Biodentine(TM) versus formocresol pulpotomy technique in primary molars: a 12-month randomized controlled clinical trial. BMC Oral Health. 2019;19(1):3.PubMedPubMedCentralCrossRef

92.

NCT03582319. Clinical and radiographic evaluation of biodentine versus formocresol. https://clinicaltrials.gov/study/NCT03582319. Completed. 2018-07–11.

93.

NCT05812053. Comparative evaluation of eggshell powder in primary teeth pulpotomy. https://clinicaltrials.gov/study/NCT05812053. Recruiting. 2023-12-07.

94.

NCT05878158. Simvastatin versus MTA in pulpotomy of immature permanent molars. https://clinicaltrials.gov/study/NCT05878158. Recruiting. 2023-05–26.

95.

NCT04710160. Clinical and radiographic evaluation in pulpotomy of primary molars using protooth vs. MTA. https://clinicaltrials.gov/study/NCT04710160. Unknown. 2021-08-05.

96.

NCT04989036. Biodentine vital pulpotomy in immature molars. https://clinicaltrials.gov/study/NCT04989036. Completed. 2021-08–04.

97.

NCT05937100. New vital pulpotomy medications in primary molars. https://clinicaltrials.gov/study/NCT05937100. Active not recruiting. 2023-07-10.

98.

Eshghi A, Hajiahmadi M, Nikbakht MH, Esmaeili M. Comparison of clinical and radiographic success between MTA and Biodentine in Pulpotomy of primary Mandibular Second molars with irreversible pulpitis: a Randomized double-blind clinical trial. Int J Dent. 2022;2022:6963944.PubMedPubMedCentralCrossRef

99.

Fernández CC, Martínez SS, Jimeno FG, Lorente Rodríguez AI, Mercadé M. Clinical and radiographic outcomes of the use of four dressing materials in pulpotomized primary molars: a randomized clinical trial with 2-year follow-up. Int J Pediatr Dent. 2013;23(6):400–7.CrossRef

100.

Fouad WA, Abd Al Gawad RY. Is biodentine, as successful as, mineral trioxide aggregate for pulpotomy of primary molars? A split-mouth clinical trial. Tanta Dent J. 2019;16(2):115–9.CrossRef

101.

Frenkel G, Kaufman A, Ashkenazi M. Clinical and radiographic outcomes of pulpotomized primary molars treated with white or gray mineral trioxide aggregate and ferric sulfate–long-term follow-up. J Clin Pediatr Dent. 2012;37(2):137–41.PubMedCrossRef

102.

Kakarla P, Avula JS, Mellela GM, Bandi S, Anche S. Dental pulp response to collagen and pulpotec cement as pulpotomy agents in primary dentition: a histological study. J Conserv Dent. 2013;16(5):434–8.PubMedPubMedCentralCrossRef

103.

NCT05747300. Wellroot PT versus MTA in pulpotomy of primary molars. https://clinicaltrials.gov/study/NCT05747300. Not Yet Recruiting. 2023-02–28.

104.

NCT05149651. Efficacy of Totalfill¬Æ and ProRoot MTA¬Æ as Pulpotomy Agent in primary molars. https://clinicaltrials.gov/study/NCT05149651. Completed. 2023-11-22.

105.

Grewal N, Salhan R, Kaur N, Patel HB. Comparative evaluation of calcium silicate-based dentin substitute (Biodentine((R))) and calcium hydroxide (pulpdent) in the formation of reactive dentin bridge in regenerative pulpotomy of vital primary teeth: triple blind, randomized clinical trial. Contemp Clin Dent. 2016;7(4):457–63.PubMedPubMedCentralCrossRef

106.

NCT03135626. Comparison of the success rates of four different pulpotomy techniques. https://clinicaltrials.gov/study/NCT03135626. Completed. 2017-05-01.

107.

NCT01962077. Comparison of MedCem MTA and formocresol used in pulpotomies in primary teeth. https://clinicaltrials.gov/study/NCT01962077. Completed. 2021-07-06.

108.

Haideri S, Koul M, Raj R, Salam SA, Kalim MS, Gupta V. To evaluate and compare the clinical and radiographic outcomes of Formocresol, Mineral Trioxide Aggregate, Electrocautery, and Bioactive Glass when used for Pulpotomy in Human Primary Teeth. J Pharm Bioallied Sci. 2021;13(Suppl 2):S1251–8.PubMedPubMedCentralCrossRef

109.

Hugar SM, Reddy R, Deshpande SD, Shigli A, Gokhale NS, Hugar SS. In vivo comparative evaluation of Mineral Trioxide Aggregate and Formocresol Pulpotomy in primary molars: a 60-month follow-up study. Contemp Clin Dent. 2017;8(1):122–7.PubMedPubMedCentralCrossRef

110.

Ildeş GÇ, Sezgin BI, Vieira AR, Mentes A. A randomized clinical trial of hyaluronic acid gel pulpotomy in primary molars with 1 year follow-up. Acta Odontol Scand. 2022;80(4):273–80.PubMedCrossRef

111.

Jayam C, Mitra M, Mishra J, Bhattacharya B, Jana B. Evaluation and comparison of white mineral trioxide aggregate and formocresol medicaments in primary tooth pulpotomy: clinical and radiographic study. J Indian Soc Pedod Prev Dent. 2018;32(1):13–8.CrossRef

112.

NCT04902495. Clinical and radiographic evaluation of pulpotomies in primary molars using tricalcium silicate cements. https://clinicaltrials.gov/study/NCT04902495. Recruiting. 2022-11-03.

113.

Joo Y, Lee T, Jeong SJ, Lee JH, Song JS, Kang CM. A randomized controlled clinical trial of premixed calcium silicate-based cements for pulpotomy in primary molars. J Dent. 2023;137:104684.PubMedCrossRef

114.

Juneja P, Kulkarni S. Clinical and radiographic comparison of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars. Eur Arch Paediatr Dent. 2017;18(4):271–8.PubMedCrossRef

115.

Junqueira MA, Cunha NNO, Caixeta FF, Marques NCT, Oliveira TM, Moretti A, et al. Clinical, radiographic and histological evaluation of primary teeth pulpotomy using MTA and ferric sulfate. Braz Dent J. 2017;29(2):159–65.CrossRef

116.

Kalra M, Garg N, Rallan M, Pathivada L, Yeluri R. Comparative evaluation of Fresh Aloe barbadensis Plant Extract and Mineral Trioxide Aggregate as Pulpotomy agents in primary molars: a 12-month follow-up study. Contemp Clin Dent. 2017;8(1):106–11.PubMedPubMedCentralCrossRef

117.

Kang CM, Kim SH, Shin Y, Lee HS, Lee JH, Kim GT, et al. A randomized controlled trial of ProRoot MTA, OrthoMTA and RetroMTA for pulpotomy in primary molars. Oral Dis. 2015;21(6):785–91.PubMedCrossRef

118.

Kang CM, Sun Y, Song JS, Pang NS, Roh BD, Lee CY, et al. A randomized controlled trial of various MTA materials for partial pulpotomy in permanent teeth. J Dent. 2017;60:8–13.PubMedCrossRef

119.

Kang CM, Seong S, Song JS, Shin Y. The role of hydraulic silicate cements on Long-Term properties and Biocompatibility of partial pulpotomy in Permanent Teeth. Mater (Basel). 2021;14(2):305.CrossRef

120.

Kathal S, Gupta S, Bhayya DP, Rao A, Roy AP, Sabhlok A. A comparative evaluation of clinical and radiographic success rate of pulpotomy in primary molars using antioxidant mix and mineral trioxide aggregate: an in vivo 1-year follow-up study. J Indian Soc Pedod Prev Dent. 2017;35(4):327–31.PubMedCrossRef

121.

NCT03718676. Pulpotomy with various MTA materials and ferric sulphate. https://clinicaltrials.gov/study/NCT03718676. Completed. 2019-03–5.

122.

Keswani D, Pandey RK, Ansari A, Gupta S. Comparative evaluation of platelet-rich fibrin and mineral trioxide aggregate as pulpotomy agents in permanent teeth with incomplete root development: a randomized controlled trial. J Endod. 2014;40(5):599–605.PubMedCrossRef

123.

NCT03395496. Comparison of biodentine and MTA pulpotomies in the primary molar teeth 3 year follow up. https://clinicaltrials.gov/study/NCT03395496. Completed. 2018-01–10.

124.

Kumar V, Juneja R, Duhan J, Sangwan P, Tewari S. Comparative evaluation of platelet-rich fibrin, mineral trioxide aggregate, and calcium hydroxide as pulpotomy agents in permanent molars with irreversible pulpitis: a randomized controlled trial. Contemp Clin Dent. 2016;7(4):512–8.PubMedPubMedCentralCrossRef

125.

Madan K, Baliga S, Deulkar P, Thosar N, Rathi N, Deshpande M, et al. A comparative evaluation between propolis and mineral trioxide aggregate as pulpotomy medicaments in primary molars. J Evol Med Dent Sci. 2020;9:1256–60.CrossRef

126.

NCT05102318. Clinical and radiographic evaluation of mineral trioxide aggregate and biodentine as pulp medicaments in primary molars. https://clinicaltrials.gov/study/NCT05102318. Unknown 2022-02-11.

127.

NCT05314842. Pulpotomy in primary molars treated with premixed bio-ceramic MTA versus formocresol. https://clinicaltrials.gov/study/NCT05314842. Not yet recruiting. 2022-04-06.

128.

Dhar V, Marghalani AA, Crystal YO, Kumar A, Ritwik P, Tulunoglu O, et al. Use of Vital Pulp Therapies in primary teeth with deep caries lesions. Pediatr Dent. 2017;39(5):146–59.PubMed

129.

Philip N, Suneja B. Minimally invasive endodontics: a new era for pulpotomy in mature permanent teeth. Br Dent J. 2022;233(12):1035–41.PubMedPubMedCentralCrossRef

130.

European Society of Endodontology developed b, Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, et al. European Society of Endodontology position statement: management of deep caries and the exposed pulp. Int Endod J. 2019;52(7):923–34.CrossRef

131.

NCT05427851. Diode laser pulpotomy of mature permanent molars with irreversible pulpitis. https://clinicaltrials.gov/study/NCT05427851. Active not recruiting. 2022-06-22.

132.

NCT04773886. Effectiveness of mineral trioxide aggregate and platelet rich fibrin along with biodentine. https://clinicaltrials.gov/study/NCT04773886. Completed. 2021-03–16.

133.

NCT04331964. The use of platelet-rich fibrin in partial pulpotomy procedure. https://clinicaltrials.gov/study/NCT04331964. Completed. 2022-02-14.

134.

Mehrvarzfar P, Abbott PV, Mashhadiabbas F, Vatanpour M, Tour Savadkouhi S. Clinical and histological responses of human dental pulp to MTA and combined MTA/treated dentin matrix in partial pulpotomy. Aust Endod J. 2017;44(1):46–53.PubMedCrossRef

135.

Manhas M, Mittal S, Sharma AK, Gupta KK, Pathania V, Thakur V. Biological approach in repair of partially inflamed dental pulp using second-generation platelet-rich fibrin and mineral trioxide aggregate as a pulp medicament in primary molars. J Indian Soc Pedod Prev Dent. 2019;37(4):399–404.PubMedCrossRef

136.

NCT05829304. A comparative clinical and radiographic study of collagen based pulpotomy in cariously exposed vital primary molars. https://clinicaltrials.gov/study/NCT05829304. Not yet recruiting. 2023-04-25.

137.

Reddy NV, Popuri SK, Velagala D, Reddy A, Puppala N. Comparative evaluation of Formocresol, Propolis and Growth factor as Pulpotomy medicaments in Deciduous Teeth-An Invivo Study. J Clin Diagn Res. 2019;13(8):29.

138.

Patidar S, Kalra N, Khatri A, Tyagi R. Clinical and radiographic comparison of platelet-rich fibrin and mineral trioxide aggregate as pulpotomy agents in primary molars. J Indian Soc Pedod Prev Dent. 2017;35(4):367–73.PubMedCrossRef

139.

Prasad MG, Adiya PVA, Babu DN, Krishna ANR. Amniotic membrane versus formocresol as pulpotomy agents in human primary molars: an in vivo study. Pesqui Bras Odontopediatria Clin Integr. 2017;17(1):1–8.

140.

Eidelman E, Holan G, Fuks AB. Mineral trioxide aggregate vs. formocresol in pulpotomized primary molars: a preliminary report. Pediatr Dent. 2001;23(1):15–8.PubMed

141.

Fuks AB, Holan G, Davis JM, Eidelman E. Ferric sulfate versus dilute formocresol in pulpotomized primary molars: long-term follow up. Pediatr Dent. 1997;19(5):327–30.PubMed

142.

Holan G, Eidelman E, Fuks AB. Long-term evaluation of pulpotomy in primary molars using mineral trioxide aggregate or formocresol. Pediatr Dent. 2005;27(2):129–36.PubMed

143.

Kusum B, Rakesh K, Richa K. Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth. Restor Dent Endod. 2015;40(4):276–85.PubMedPubMedCentralCrossRef

144.

de Araujo Junior RF, Souza TO, de Medeiros CA, de Souza LB, Freitas Mde L, de Lucena HF, et al. Carvedilol decrease IL-1beta and TNF-alpha, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis. PLoS ONE. 2013;8(7):e66391.PubMedPubMedCentralCrossRef

145.

Kanzaki H, Chiba M, Shimizu Y, Mitani H. Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Min Res. 2002;17(2):210–20.CrossRef

146.

Wang L, Zhou Z, Chen Y, Yuan S, Du Y, Ju X, et al. The alpha 7 Nicotinic Acetylcholine receptor of Deciduous Dental Pulp Stem cells regulates Osteoclastogenesis during physiological Root Resorption. Stem Cells Dev. 2017;26(16):1186–98.PubMedCrossRef

147.

Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest. 2005;115(2):282–90.PubMedPubMedCentralCrossRef

148.

Yaman E, Gorken F, Pinar Erdem A, Sepet E, Aytepe Z. Effects of folk medicinal plant extract Ankaferd Blood stopper((R)) in vital primary molar pulpotomy. Eur Arch Paediatr Dent. 2012;13(4):197–202.PubMedCrossRef

149.

AAE Position Statement on Vital Pulp Therapy. J Endod. 2021;47(9):1340–4.CrossRef

150.

NCT04719247. Clinical and radiographic evaluation of turmeric, thymus vulgaris, nigella sativa and aloe vera as pulpotomy medicaments in primary teeth. https://clinicaltrials.gov/study/NCT04719247 Completed. 2021-12-15.

151.

Cosme-Silva L, Sakai VT, Lopes CS, Silveira APPd, Moretti RT, Gomes-Filho JE, et al. Comparison between calcium hydroxide mixtures and mineral trioxide aggregate in primary teeth pulpotomy: a randomized controlled trial. J Appl Oral Sci. 2019;27:e20180030.PubMedPubMedCentralCrossRef

152.

Bakhtiar H, Nekoofar MH, Aminishakib P, Abedi F, Naghi Moosavi F, Esnaashari E, et al. Human pulp responses to partial pulpotomy treatment with TheraCal as compared with biodentine and ProRoot MTA: a clinical trial. J Endod. 2017;43(11):1786–91.PubMedCrossRef

153.

Bakhtiar H, Aminishakib P, Ellini MR, Mosavi F, Abedi F, Esmailian S, et al. Dental Pulp response to RetroMTA after partial pulpotomy in Permanent Human Teeth. J Endod. 2018;44(11):1692–6.PubMedCrossRef

154.

Bhagat D, Sunder RK, Devendrappa SN, Vanka A, Choudaha N. A comparative evaluation of ProRoot mineral trioxide aggregate and Portland cement as a pulpotomy medicament. J Indian Soc Pedod Prev Dent. 2017;34(2):172–6.CrossRef

155.

El Meligy OA, Allazzam S, Alamoudi NM. Comparison between biodentine and formocresol for pulpotomy of primary teeth: a randomized clinical trial. Quintessence Int. 2016;47(7):571–80.PubMed

156.

NCT04617600. Survival rate after TheraCal PT pulpotomy versus MTA pulpotomy in children with vital primary molars. https://clinicaltrials.gov/study/NCT04617600. Not yet recruiting. 2022-03-04.

157.

Lourenço Neto N, Marques NC, Fernandes AP, Rodini CO, Sakai VT, Abdo RC, et al. Immunolocalization of dentin matrix protein-1 in human primary teeth treated with different pulp capping materials. J Biomedical Mater Res Part B Appl Biomaterials. 2016;104(1):165–9.CrossRef

158.

Xu D, Mutoh N, Ohshima H, Tani-Ishii N. The effect of mineral trioxide aggregate on dental pulp healing in the infected pulp by direct pulp capping. Dent Mater J. 2021;40(6):1373–9.PubMedCrossRef

159.

de Menezes JV, Takamori ER, Bijella MF, Granjeiro JM. In vitro toxicity of MTA compared with other primary teeth pulpotomy agents. J Clin Pediatr Dent. 2009;33(3):217–21.PubMedCrossRef

160.

Mendoza-Mendoza A, Biedma-Perea M, Iglesias-Linares A, Abalos-Labruzzi C, Solano-Mendoza B. Effect of mineral trioxide aggregate (MTA) pulpotomies in primary molars on their permanent tooth successors. Am J Dent. 2014;27(5):268–72.PubMed

161.

Bani M, Aktas N, Cinar C, Odabas ME. The clinical and radiographic success of primary molar pulpotomy using Biodentine and Mineral Trioxide Aggregate: a 24-Month Randomized Clinical Trial. Pediatr Dent. 2017;39(4):284–8.PubMed

162.

Rahul M, Lokade A, Tewari N, Mathur V, Agarwal D, Goel S, et al. Effect of Intracanal scaffolds on the Success Outcomes of Regenerative Endodontic Therapy - A Systematic Review and network Meta-analysis. J Endod. 2023;49(2):110–28.PubMedCrossRef

163.

Ulusoy AT, Turedi I, Cimen M, Cehreli ZC. Evaluation of blood clot, platelet-rich plasma, platelet-rich fibrin, and platelet pellet as scaffolds in Regenerative Endodontic treatment: a prospective Randomized Trial. J Endod. 2019;45(5):560–6.PubMedCrossRef

164.

Miron RJ, Zucchelli G, Pikos MA, Salama M, Lee S, Guillemette V, et al. Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clin Oral Invest. 2017;21(6):1913–27.CrossRef

165.

Noor Mohamed R, Basha S, Al-Thomali Y. Efficacy of platelet concentrates in pulpotomy - a systematic review. Platelets. 2018;29(5):440–5.PubMedCrossRef

166.

Gandhi K, Goswami P, Malhotra R. Phlebotomy for obtaining platelet-rich fibrin autograft in children for pediatric dental procedures: parental views, understanding, and acceptance. J Indian Soc Pedod Prev Dent. 2020;38(2):119–25.PubMedCrossRef

167.

NCT03200938. Clinical applicability of PBS¬Æ CIMMO cement in pulpotomies. https://clinicaltrials.gov/study/NCT03200938. Completed. 2020-12-31.

168.

Sajadi FS, Jalali F, Khademi M. Ferric sulfate versus calcium-enriched mixture cement in pulpotomy of primary molars: a randomized clinical trial. Pesquisa Brasileira em Odontopediatria E Clínica Integrada. 2021;21:7.CrossRef

169.

Mejare IA, Axelsson S, Davidson T, Frisk F, Hakeberg M, Kvist T, et al. Diagnosis of the condition of the dental pulp: a systematic review. Int Endod J. 2012;45(7):597–613.PubMedCrossRef

170.

Ballal NV, Duncan HF, Wiedemeier DB, Rai N, Jalan P, Bhat V, et al. MMP-9 levels and NaOCl Lavage in Randomized Trial on Direct Pulp Capping. J Dent Res. 2022;101(4):414–9.PubMedCrossRef

171.

Kaur B, Kobayashi Y, Cugini C, Shimizumi E. A Mini Review: the potential biomarkers for non-invasive diagnosis of Pulpal inflammation. Front Dent Med. 2021;2:1–13.CrossRef

172.

Riccaboni M, Verginer L. The impact of the COVID-19 pandemic on scientific research in the life sciences. PLoS ONE. 2022;17(2):e0263001.PubMedPubMedCentralCrossRef

173.

El karim I, Duncan H. Reducing intervention in the COVID-19 era: opportunities for Vital Pulp Treatment. Front Dent Med. 2021;2:1–7.CrossRef

174.

Asagry S, Shamszadeh S, Editorial. COVID-19 and Endodontic emergencies. Iran Endod J. 2020;15(2):64.PubMedPubMedCentral

Title: Outcome assessment methods of bioactive and biodegradable materials as pulpotomy agents in primary and permanent teeth: a scoping review
Authors: Yasmine Elhamouly
May M. Adham
Karin M L Dowidar
Rania M. El Backly
Publication date: 01-12-2024
Publisher: BioMed Central
Published in: BMC Oral Health / Issue 1/2024
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-024-04221-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Outcome assessment methods of bioactive and biodegradable materials as pulpotomy agents in primary and permanent teeth: a scoping review

Abstract

Background

Objectives

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objectives

Materials and methods

Results

Conclusions

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