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BMC Urology
Published in: BMC Urology 1/2023

Open Access 01-12-2023 | Prostate Cancer | Research

Predictive value of systematic immune-inflammation index combined with Ki-67 index on prognosis of prostate cancer patients after laparoscopic radical prostatectomy

Authors: Rongxin Wu, Mingjin Hu, Pei Zhang

Published in: BMC Urology | Issue 1/2023

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Abstract

Background

Prostate cancer (PCa) presents a wide spectrum. Systemic immune-inflammation index (SII) and Ki-67 index are new biomarkers that can predict prognosis in different types of cancer. We explored the predictive value of their combination on the prognosis of PCa patients after laparoscopic radical prostatectomy (LRP).

Methods

In this retrospective study, 290 patients who underwent LRP at Nanjing Lishui People’s Hospital between January 2016 and February 2021 were enrolled. They were divided into the good prognosis group (N = 235) and poor prognosis group (N = 55) based on the follow-up results. Both the baseline data and postoperative pathological results were collected. The Ki-67 index was determined using immunohistochemical kits, and the patients were allocated to the SII/Ki-67 index high/low expression groups according to the cut-off values to further analyze their relationship with clinical/pathological data of PCa patients. Logistics multivariate regression analysis was utilized to analyze the independent factors affecting post-LRP prognosis of CPa patients. ROC curve was plotted to assess the predictive value for post-LRP prognosis, and Kaplan-Meier curve/Log-rank were used for analysis.

Results

Significant differences were found in PSA/Gleason score/T stage/lymph node metastasis/seminal vesicle invasion/neutrophils/lymphocytes/platelets/preoperative SII/Ki-67 index between the good/poor prognosis groups. Preoperative SII/Ki-67 were related to PSA/lymphocytes/platelets in PCa. Seminal vesicle invasion and preoperative SII + Ki-67 index were independent factors affecting post-LRP prognosis. Preoperative SII + Ki-67 index had a better predictive value than preoperative SII or Ki-67 index alone. Patients with high preoperative SII and Ki-67 index levels had an increased risk of poor prognosis after LRP.

Conclusion

Preoperative SII + Ki-67 index had a better predictive value for poor prognosis after LRP than SII or Ki-67 index alone.
Literature
1.
Adamaki M, Zoumpourlis V. Prostate Cancer biomarkers: from diagnosis to prognosis and precision-guided therapeutics. Pharmacol Ther. 2021;228:107932.CrossRefPubMed
2.
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33.CrossRefPubMed
3.
Sekhoacha M, Riet K, Motloung P, Gumenku L, Adegoke A, Mashele S. Prostate Cancer Review: Genetics, diagnosis, Treatment options, and alternative approaches. Molecules. 2022;27(17).
4.
Wang K, Zhuang Q, Xu R, Lu H, Song G, Wang J, Tian Z, Mao Q, Gong P. Transperitoneal versus extraperitoneal approach in laparoscopic radical prostatectomy: a meta-analysis. Med (Baltim). 2018;97(29):e11176.CrossRef
5.
Coughlin GD, Yaxley JW, Chambers SK, Occhipinti S, Samaratunga H, Zajdlewicz L, Teloken P, Dunglison N, Williams S, Lavin MF, et al. Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: 24-month outcomes from a randomised controlled study. Lancet Oncol. 2018;19(8):1051–60.CrossRefPubMed
6.
Meng J, Zhou Y, Lu X, Bian Z, Chen Y, Zhou J, Zhang L, Hao Z, Zhang M, Liang C. Immune response drives outcomes in Prostate cancer: implications for immunotherapy. Mol Oncol. 2021;15(5):1358–75.CrossRefPubMed
7.
Porter CM, Shrestha E, Peiffer LB, Sfanos KS. The microbiome in prostate inflammation and Prostate cancer. Prostate Cancer Prostatic Dis. 2018;21(3):345–54.CrossRefPubMed
8.
Li J, Cao D, Huang Y, Xiong Q, Tan D, Liu L, Lin T, Wei Q. The prognostic and clinicopathological significance of systemic Immune-inflammation index in Bladder Cancer. Front Immunol. 2022;13:865643.CrossRefPubMedPubMedCentral
9.
Li X, Gu L, Chen Y, Chong Y, Wang X, Guo P, He D. Systemic immune-inflammation index is a promising non-invasive biomarker for predicting the survival of urinary system cancers: a systematic review and meta-analysis. Ann Med. 2021;53(1):1827–38.CrossRefPubMedPubMedCentral
10.
Fan L, Wang R, Chi C, Cai W, Zhang Y, Qian H, Shao X, Wang Y, Xu F, Pan J, et al. Systemic immune-inflammation index predicts the combined clinical outcome after sequential therapy with abiraterone and docetaxel for metastatic castration-resistant Prostate cancer patients. Prostate. 2018;78(4):250–6.CrossRefPubMed
11.
Ma T, Yang S, Jing H, Cong L, Cao Z, Liu Z, Huang Z. Apparent diffusion coefficients in Prostate cancer: correlation with molecular markers Ki-67, HIF-1alpha and VEGF. NMR Biomed. 2018;31(3).
12.
13.
Mathieu R, Shariat SF, Seitz C, Karakiewicz PI, Fajkovic H, Sun M, Lotan Y, Scherr DS, Tewari A, Montorsi F, et al. Multi-institutional validation of the prognostic value of Ki-67 labeling index in patients treated with radical prostatectomy. World J Urol. 2015;33(8):1165–71.CrossRefPubMed
14.
Blessin NC, Yang C, Mandelkow T, Raedler JB, Li W, Bady E, Simon R, Vettorazzi E, Lennartz M, Bernreuther C, et al. Automated Ki-67 labeling index assessment in Prostate cancer using artificial intelligence and multiplex fluorescence immunohistochemistry. J Pathol. 2023;260(1):5–16.CrossRefPubMed
15.
Rizzo A, Santoni M, Mollica V, Fiorentino M, Brandi G, Massari F. Microbiota and Prostate cancer. Semin Cancer Biol. 2022;86(Pt 3):1058–65.CrossRefPubMed
16.
Chang AJ, Autio KA, Roach M 3rd, Scher HI. High-risk prostate cancer-classification and therapy. Nat Rev Clin Oncol. 2014;11(6):308–23.
17.
Cao L, Yang Z, Qi L, Chen M. Robot-assisted and laparoscopic vs open radical prostatectomy in clinically localized Prostate cancer: perioperative, functional, and oncological outcomes: a systematic review and meta-analysis. Med (Baltim). 2019;98(22):e15770.CrossRef
18.
Feng JF, Chen S, Yang X. Systemic immune-inflammation index (SII) is a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus. Med (Baltim). 2017;96(4):e5886.CrossRef
19.
Hong X, Cui B, Wang M, Yang Z, Wang L, Xu Q. Systemic Immune-inflammation index, based on platelet counts and neutrophil-lymphocyte ratio, is useful for Predicting Prognosis in Small Cell Lung Cancer. Tohoku J Exp Med. 2015;236(4):297–304.CrossRefPubMed
20.
Lolli C, Basso U, Derosa L, Scarpi E, Sava T, Santoni M, Crabb SJ, Massari F, Aieta M, Conteduca V, et al. Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib. Oncotarget. 2016;7(34):54564–71.CrossRefPubMedPubMedCentral
21.
Lolli C, Caffo O, Scarpi E, Aieta M, Conteduca V, Maines F, Bianchi E, Massari F, Veccia A, Chiuri VE, et al. Systemic Immune-inflammation index predicts the clinical outcome in patients with mCRPC treated with Abiraterone. Front Pharmacol. 2016;7:376.CrossRefPubMedPubMedCentral
22.
Gerdes J. Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. Semin Cancer Biol. 1990;1(3):199–206.PubMed
23.
Liang R, Chen N, Li M, Wang X, Mao Q, Liu Y. Significance of systemic immune-inflammation index in the differential diagnosis of high- and low-grade gliomas. Clin Neurol Neurosurg. 2018;164:50–2.CrossRefPubMed
24.
Zhang S, Ni Q. Prognostic role of the pretreatment systemic immune-inflammation index in patients with glioma: a meta-analysis. Front Neurol. 2023;14:1094364.CrossRefPubMedPubMedCentral
25.
Meng L, Yang Y, Hu X, Zhang R, Li X. Prognostic value of the pretreatment systemic immune-inflammation index in patients with Prostate cancer: a systematic review and meta-analysis. J Transl Med. 2023;21(1):79.CrossRefPubMedPubMedCentral
26.
Qi W, Zhou Y, Liu Z, Wang J, Lv G, Zhong M, Wang W, Li R, Chen S, Shi B, et al. Revealing the prognostic and clinicopathological significance of systemic immune-inflammation index in patients with different stage Prostate cancer: a systematic review and meta-analysis. Front Med (Lausanne). 2022;9:1052943.CrossRefPubMed
27.
Li R, Heydon K, Hammond ME, Grignon DJ, Roach M 3rd, Wolkov HB, Sandler HM, Shipley WU, Pollack A. Ki-67 staining index predicts distant Metastasis and survival in locally advanced Prostate cancer treated with radiotherapy: an analysis of patients in radiation therapy oncology group protocol 86 – 10. Clin Cancer Res. 2004;10(12 Pt 1):4118–24.
28.
Cho U, Oh WJ, Hong YK, Lee YS. Prognostic significance of high Ki-67 index and histogenetic subclassification in primary Central Nervous System Lymphoma. Appl Immunohistochem Mol Morphol. 2018;26(4):254–62.CrossRefPubMed
Metadata
Title
Predictive value of systematic immune-inflammation index combined with Ki-67 index on prognosis of prostate cancer patients after laparoscopic radical prostatectomy
Authors
Rongxin Wu
Mingjin Hu
Pei Zhang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2023
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-023-01379-3

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